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  • 1
    Electronic Resource
    Electronic Resource
    Distribution of filipin-sterol complexes in the myelinated nerve fiber
    Amsterdam : Elsevier
    Journal of Ultrasructure Research 91 (1985), S. 104-111 
    Details
    ISSN: 0022-5320
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0889-1605(85)90062-X
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of Infection with Trypanosomes on the Development of Experimental Allergic Neuritis in Rabbits (1971)
    [s.l.] : Nature Publishing Group
    Nature 233 (1971), S. 197-199 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Adult New Zealand white rabbits of both sexes were infected by intraperitoneal inoculation of blood from mice infected with trypanosome parasites; five received Trypanosoma brucei brucei (Serial No. LUMP 143) which is maintained as a stabilate7, and seven received a T. brucei parasite (strain S 427 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/233197b0
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  • 3
    Electronic Resource
    Electronic Resource
    Filipin-sterol complexes at Schmidt-Lanterman incisures (1987)
    Springer
    Acta neuropathologica 72 (1987), S. 355-361 
    Details
    ISSN: 1432-0533
    Keywords: Filipin ; Cholesterol ; Schmidt-Lanterman incisures ; Myelin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Employing the freeze-fracture technique, the distribution of filipin-sterol complexes was determined for membranes of peripheral nerve myelin. A heterogeneous distribution of complexes was observed with the greatest abundance on membranes associated with the cytoplasmic channels of Schmidt-Lanterman and longitudinal incisures. In addition there was an irregular network of well-labelled membrane bands in compact myelin. The results are related to a possible role for these channels and bands in the biochemical turnover of cholesterol in myelin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687267
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  • 4
    Electronic Resource
    Electronic Resource
    Axonal microtubules: a computer-linked quantitative analysis (1985)
    Springer
    Anatomy and embryology 171 (1985), S. 339-344 
    Details
    ISSN: 1432-0568
    Keywords: Microtubules ; Myelinated axons ; Morphometry ; Computer analysis ; Literature review
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Employing current computer-aided morphometric techniques, axonal microtubule density was determined for the rat sural nerve. Analysis of extensive data showed that while microtubule number increases with axon size, the increase is not directly proportional. Thus the relationship between microtubule density and axonal size is inversely related, so that microtubule density is greater in smaller axons than in larger axons. When a proximal and distal site, separated by 2 cm, were compared for microtubule density there was no significant difference, using pooled data for all fibre diameters. The results are interpreted in terms of our present knowledge of axonal-microtubule quantitative relationships, which is reviewed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00347022
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  • 5
    Electronic Resource
    Electronic Resource
    Diffusion barrier properties of the perineurium: an in vivo ionic lanthanum tracer study (1989)
    Springer
    Anatomy and embryology 180 (1989), S. 237-242 
    Details
    ISSN: 1432-0568
    Keywords: Perineurium ; Lanthanum ; Diffusion barriers ; In vivo ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary While the perineurium as a diffusion barrier has been extensively investigated by light and electron microscopy, copy, such studies have been largely restricted to the use of protein tracers. In the present study the permeability of the perineurium to a physiologically more relevant ionic tracer has been assessed. In vivo the rat sural or tibial nerve was either microinjected with lanthanum nitrate solution for endoneurial application or bathed in the lanthanum solution for epineurial application. The findings generally demonstrated an effective barrier to the tracer which failed to penetrate the inner layers of the perineurium. Only at the highest lanthanum concentration and longest time intervals employed did trace quantities occasionally penetrate the barrier and then only in the presence of some cytopathological changes to the outermost perineurial cells. The usefulness of the microinjection method was limited by the slight but unavoidable trauma to the perineurium. The findings are related to those of other studies which have used electron dense tracers, also to studies using physiological including electrophysiological techniques and morphological including freeze-fracture methods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315882
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  • 6
    Electronic Resource
    Electronic Resource
    Cerebral and pial microvessels: differential expression of γ-glutamyl transpeptidase and alkaline phosphatase (1999)
    Springer
    Anatomy and embryology 199 (1999), S. 29-34 
    Details
    ISSN: 1432-0568
    Keywords: Key words γ-Glutamyl transpeptidase ; Alkaline phosphatase ; Blood-brain barrier ; Pial microvessels ; Astrocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Pial microvessels have several important blood-brain barrier (BBB) characteristics in common with cerebral microvessels, despite lacking their astrocytic ensheathment. We have therefore determined whether they have the same distribution of two enzymes, γ-glutamyl transpeptidase (GGTP) and alkaline phosphatase, both of which are known to be astrocyte-dependent. GGTP was absent from all rat pial microvessels but strongly present in brain cortical capillaries. Alkaline phosphatase was heterogeneously expressed in pial microvessels, including capillaries, but strongly positive in brain cortical capillaries. Diffusible, inductive factors produced by astrocytes could account for these differences in enzyme distribution between the two vessel types. Furthermore, differences in expression between the two markers may reflect their differing sensitivities to the astrocytic factors. Caution is urged in the common usage of the pial microvessel as a model system in BBB studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004290050206
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  • 7
    Electronic Resource
    Electronic Resource
    Substance P-induced enhanced permeability of dura mater microvessels is accompanied by pronounced ultrastructural changes, but is not dependent on the density of endothelial cell anionic sites (1999)
    Springer
    Acta neuropathologica 97 (1999), S. 297-305 
    Details
    ISSN: 1432-0533
    Keywords: Key words Dura ; Endothelium ; Headache ; Substance P ; Surface charge
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Experimental data point to a determinant role for endothelial cell (EC) anionic sites in the regulation of vascular permeability. Previous studies have shown that EC anionic sites density is reduced in conditions of enhanced permeability. The pathophysiology of migraine and vascular headache encompasses dilatation of dural vessels and extravasation of plasma proteins. The current study was carried out to determine if the density of EC anionic sites is reduced in enhanced permeability of dural vessels. Enhanced permeability was chemically induced in rats by intravenous injection of substance P and was tested by assessing leakage of horseradish peroxidase (HRP). Anionic sites were labelled with cationic colloidal gold and their density was quantified from electron microscopy negatives. Experimental animals showed increased leakage of HRP from dural vessels. However, anionic sites in EC membranes (luminal and abluminal) showed no statistical differences when their mean densities in experimental and control animals were compared. The results indicate that in this model, factors other than the density of anionic sites may be important determinants in the permeability of dural vessels. Such factors may include structural alteration of ECs consistent with an increased permeability. In this study pronounced ultrastructural changes in ECs were noted in experimental animals including widening of intercellular junctions and an increase in the number of EC gaps and vesicles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050988
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  • 8
    Electronic Resource
    Electronic Resource
    Lysophosphatidyl choline-induced demyelination (1988)
    Springer
    Acta neuropathologica 75 (1988), S. 456-464 
    Details
    ISSN: 1432-0533
    Keywords: Demyelination ; Lysophosphatidyl choline ; Freeze-fracture ; Vesiculation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Focal demyelination was produced in the rat sciatic nerve by microinjection of lysophosphatidyl choline (LPC). The demyelinating lesion was examined over the following 48 h using the freeze-fracture technique to examine myelin, Schwann cell and axonal membranes. Myelin lamellae were replaced by myriad spherical or oval membranous vesicles. The axonal and Schwann cell plasma membranes remained intact and the latter showed a large increase in caveolae-associated pores in some nerve fibres. The lysis of myelin lamellae and membranous vesicle formation are related to the known action of LPC on myelin and its membrane fusogenic properties. The importance of calcium ion influx and membrane protein aggregation and depletion in vesiculation are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687132
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  • 9
    Electronic Resource
    Electronic Resource
    Involvement of the perineurium in experimental allergic neuritis: Electron microscopic observations (1972)
    Springer
    Acta neuropathologica 20 (1972), S. 139-149 
    Details
    ISSN: 1432-0533
    Keywords: Perineurium ; Experimental Allergic Neuritis ; Extravasated Protein ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Electron microscopic observations on the perineurium in EAN are described. Extravasated serum protein was observed in the endoneurial space and also between the cellular laminae of the perineurium. A mechanism of macropinocytotic transport of protein across the perineurium is proposed. The observations are related to the known properties of the perineurium as a diffusion barrier and are interpreted as a mechanism by the perineurium to restore the composition of the endoneurial fluid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691130
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  • 10
    Electronic Resource
    Electronic Resource
    A study of the capacity of myelinated and unmyelinated nerves to induce experimental allergic neuritis (1972)
    Springer
    Acta neuropathologica 21 (1972), S. 99-108 
    Details
    ISSN: 1432-0533
    Keywords: Experimental Allergic Neuritis ; Unmyelinated “Antigen” ; Schwann Cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The capacity of myelin-free Schwann cells to induce EAN was investigated. Human foetal peripheral nerve and human adult abdominal vagus nerve, both containing little or no myelin, failed to induce EAN when injected intradermally (together with Freund's adjuvant) into rabbits. In contrast, human adult sciatic nerve, which is heavily myelinated, induced characteristic signs and histopathology of EAN. Thus in the “myelin-free” “antigens” Schwann cell plasma membrane, from which myelin is apparently derived, failed to induce EAN. Reasons for this paradox are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687564
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