ISSN:
1573-8221
Keywords:
Thy-1 +-cells
;
committed precursors of hemopoiesis
;
S-phase
;
adrenergic structures
;
5-fluorouracil
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract After administration of 5-fluorouracil in a high dose (114 mg/kg), the proliferation of committed precursors of erythro- and granulomonocytopoiesis is controlled by sympatheticoadrenal system. On the one hand, catecholamines facilitate, predominantly via β-structures, the migration of Thy-1+-cells that stimulate hemopoietic precursors for the S-phase of cell cycle. On the other hand, sympatheticoadrenal transmitters potentiate via β- and α-adrenoreceptors the suppressor activity of the cytostatic on the growth and maturation of erythropoietic and, to a lesser extent, granulocytopoietic precursors. These factors may contribute to the process of long restoration of the granulocyte and, to a higher extent, erythrocyte stem cells in the bone marrow after a high dose of 5-fluorouracil.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02458075
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