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  • Articles: DFG German National Licenses  (60)
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  • Articles: DFG German National Licenses  (60)
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  • 1
    Electronic Resource
    Electronic Resource
    HOMOCARNOSINOSIS: INCREASED CONTENT OF HOMOCARNOSINE AND DEFICIENCY OF HOMOCARNOSINASE IN BRAIN (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 32 (1979), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Biochemical studies were carried out on a brain biopsy obtained from a 40 y old woman with homocarnosinosis. This patient and 2 of her siblings have a progressive neurological disorder characterized by spastic paraplegia, dementia and retinal pigmentation. Homocarnosine concentrations in their CSF, as well as in the CSF of their neurologically normal mother, are elevated 20-40-fold. Homocarnosine content was 4 times higher in the patient's frontal cortex than in biopsied cortex from a large group of control subjects. The activity of the synthetic enzyme, homocarnosine-carnosine synthetase. was not increased in the homocarnosinosis patient's brain. Homocarnosinase activity, however, was undetectable in the patient's brain biopsy, while it could readily be measured in comparable biopsies from control subjects. We conclude that homocarnosinase deficiency is probably inhcrited as an autosomal recessive trait, but that it is unlikely of itself to have caused the neurological syndrome affecting our patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1979.tb02273.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Variants of chronic paroxysmal hemicrania; a reply to Seymour Solomon (1989)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 9 (1989), S. 0 
    Details
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-2982.1989.0901078-2.x
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  • 3
    Electronic Resource
    Electronic Resource
    Arachidonic acid metabolism in polymorphonuclear cells in headaches (1988)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 8 (1988), S. 0 
    Details
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Prostaglandins and leukotrienes have been implicated in the pathogenesis of various types of headache, mainly because some, but not all, cyclo-oxygenase inhibitors are effective in their treatment. We have therefore investigated whether a pathologically changed turnover of arachidonic acid (AA)-containing phospholipids can be seen in headache patients, using isolated polymorphonuclear cells (PMNs) from healthy controls and patients with chronic paroxysmal hemicrania (CPH) and cluster headache. PMNs from healthy controls incorporated 55% of the added (1-14C)AA into total lipids, and 0.5% ± 0.14% of this radioactivity was found in the phosphatidylserine (PS) fraction. PMNs from a cluster headache and a CPH patient showed 300% and 900% increase in PS labeling from AA, respectively. No other phospholipids showed any difference between controls and patients. The results are discussed in connection with membrane signal transduction via the PS-dependent protein kinase C.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-2982.1988.0803149.x
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  • 4
    Electronic Resource
    Electronic Resource
    Chronic paroxysmal hemicrania (1988)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 8 (1988), S. 0 
    Details
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Pupillometric studies were carried out in eight patients with chronic paroxysmal hemicrania (CPH) and in age- and sex-matched controls in the basal condition and after instillation of 2% tyramine (CPH, n = 5; controls, n = 17), 1% OH-amphetamine (CPH, n = 6; controls, n = 12), and 1% phenylephrine (CPH, n = 6; controls, n = 17). The pupil on the symptomatic and non-symptomatic sides in CPH patients was significantly smaller in the basal condition than in controls, particularly on the symptomatic side. The mydriatic responses to pharmacologic stimulation were essentially similar on the symptomatic and non-symptomatic sides. An evaporimetric study of the forehead sweat glands, using the body heating and pilocarpine tests, was also carried out in these patients and in age- and sex-matched controls. “Early”, “intermediate”, and “late” measurements demonstrated symmetry of forehead sweating. The findings for both methods of examination thus contrast with those in cluster headache patients. Pupillometric and forehead sweating patterns therefore suggest differences in the pathogenesis of the two headache entities. These tests may be used to distinguish CPH and cluster headache clinically.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-2982.1988.0803219.x
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  • 5
    Electronic Resource
    Electronic Resource
    “Hemicrania continua”—new developments (1987)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 7 (1987), S. 0 
    Details
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-2982.1987.0703163.x
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  • 6
    Electronic Resource
    Electronic Resource
    Unilaterality of headache. Hauge's studies revisited (1983)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 3 (1983), S. 0 
    Details
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-2982.1983.0304202.x
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  • 7
    Electronic Resource
    Electronic Resource
    Chronic paroxysmal hemicrania. IX. On the mechanism of attack-related sweating (1983)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 3 (1983), S. 0 
    Details
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In eight patients with chronic paroxysmal hemicrania (CPH), forehead sweating was measured after various provocation tests-body heating, exercise, and subcutaneous pilocarpine administration (0.1 mg/kg body weight). Evaporation was measured bilaterally on the forehead with an Evaporimeter (in g/m2/h). This was carried out in a thermo room under standardized conditions. There was no definite deficit in heat-induced or exercise-induced sweating on the symptomatic side of the forehead, contrary to findings in cluster headache. Neither did pilocarpine lead to any marked initial, temporary predominance of sweating on the symptomatic side, which has previously been found in cluster headache. In cluster headache there may be denervation supersensitivity of the sweat glands in the forehead of the symptomatic side. The present study does not therefore provide evidence for supersensitivity phenomena which could explain the homolateral forehead sweating increase seen during attacks in some CPH patients. The localized sweating increase in the forehead during attacks of CPH may possibly be a result of direct sympathetic stimulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-2982.1983.0303191.x
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  • 8
    Electronic Resource
    Electronic Resource
    Chronic paroxysmal hemicrania. VIII. The sweating pattern (1983)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 3 (1983), S. 0 
    Details
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Evaporimeter measurements of forehead sweating during attack were carried out in six female patients with chronic paroxysmal hemicrania. The patients served as their own controls. Increased sweating on the symptomatic side was found in two patients. both when compared to the non-symptomatic side during attack and when compared with the symptomatic side outside attack. The remaining four patients, two of whom had only weak attacks at the time of study, showed sweat values within the control range. In one patient, attacks could be precipitated by head flexion and by pressure against certain circumscribed points in the neck (“mechanical” precipitation of attacks). These attacks were also associated with increased sweating on the symptomatic side. Increased forehead sweating does not seem to be a sine qua non in CPH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-2982.1983.0301045.x
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  • 9
    Electronic Resource
    Electronic Resource
    Chronic paroxysmal hemicrania. VI. Precipitation of attacks. Further studies on the precipitation mechanism (1982)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 2 (1982), S. 0 
    Details
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In four of the approximately 40 cases of chronic paroxysmal hemicrania (CPH) that are known so far, attacks that are similar to the spontaneous ones may be precipitated by head movements or pressure against certain points in the neck. Head flexion was used as the precipitation procedure in a 34-year-old female who was studied several times in the course ot five years. Attacks occur within 5–40 sec, and the pain is preceded by tearing and conjunctival injection. External rubbing or external compression of the common and internal carotid arteries on the symptomatic side did not produce attacks. The combination of head flexion and external compression of the common or internal carotid arteries on the symptomatic side invariably produced an attack of usual severity and within the usual time. This investigation would seem to render unlikely the possibility of a primary vascular mediation of the signal from the neck to the ocular region. Sympathetic fibres are the likely mediators of the impulses from the neck to the ocular area.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-2982.1982.0204211.x
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  • 10
    Electronic Resource
    Electronic Resource
    Epilogue (1989)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 9 (1989), S. 0 
    Details
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-2982.1989.0904232.x
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