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  • Electronic Resource  (2)
  • 1965-1969  (2)
  • 1960-1964
  • 1950-1954
  • 1968  (2)
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  • Electronic Resource  (2)
Years
  • 1965-1969  (2)
  • 1960-1964
  • 1950-1954
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Chromosoma 25 (1968), S. 184-197 
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The submicroscopic organization of terminal chromosome regions of Drosophila hydei polytene chromosomes is described. A compact region composed of tightly packed fibrils of 100 to 125 Å diameter embedded in an amorphous material is located at each of the chromosome ends of the 5 long chromosome arms. From this compact region, sometimes containing cavities, fibrils extend onto the nearest normal band region. The diameter of the extending fibrils is 100–125 Å, 200–250 Å or 400 Å. Pronase digestion of fixed and squashed chromosomes reduced the electron density of the amorphous matrix in the compact regions but failed to affect the diameter of the fibrils. The extending fibrils, however, showed a decrease in diameter after pronase digestion. The most frequently observed diameter values were 100–125 Å. — The volume of the terminal structures, including the compact region as well as the extending fibrils, is characteristically different for the various elements of the karyotype. Chromosome 2 displays the largest terminal structure, whereas chromosome 4 only occasionally shows the presence of compact regions. — End to end association of the long chromosome arms involves the fusion of the compact terminal structures. The non-random distribution of end to end association seems to be correlated with the volume of the terminal structures. Chromosome 2 which contains the largest compact terminal region is more frequently involved in end to end associations than any other chromosome arm. — The terminal regions show replication of DNA. They belong to the group of regions which display a discontinuous labeling pattern along the chromosomes, representing a late phase of the replication cycle. — The unique structural organization of the terminal chromosome regions, which is never observed at any other location of the genome supports the idea that they are morphological manifestations of the postulated telomeres.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 46 (1968), S. 712-716 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Blood coagulatio and fibrinolysis were studied on 25 untrained male volunteers and on 10 highly trained athletes immediately after graduated exercise on a bicycle ergometer. We found, in particular, a shortening of the reaction time in the thrombelastogram, an accelerated thrombin formation and increased thrombin activity in the thrombin generation test, an increase of factor VIII activity, a shortening of thromboplastin times and a shortening of euglobulin lysis times in relationship to the degree of physical stress. Measurement of the three latter changes was conducted on a comparative basis between untrained subjects and highly trained athletes. Here the athletes showed lesser increases in activity as regards coagulation and fibrinolysis, in comparison to untrained persons of the same age during a standard exercise of 150 Watts. During maximal ergometer exercise the values of both test groups corresponded with one another to a large extent.
    Notes: Zusammenfassung Bei 25 untrainierten jugendlichen Versuchspersonen und 10 Hochleistungssportlern wurde das Verhalten der Blutgerinnung und Fibrinolyse während einer abgestuften Ergometerbelastung mit Hilfe verschiedener Methoden untersucht. Im einzelnen konnten eine Verkürzung der Reaktionszeit im Thrombelastogramm, eine beschleunigte Thrombinbildung und gesteigerte Thrombinaktivität im Thrombinbildungstest, eine Zunahme der Faktor VIII-Aktivität, ein Anstieg der Quick-Werte und eine Verkürzung der Euglobulin-Lysezeiten in Abhängigkeit vom Grad der körperlichen Belastung nachgewiesen werden. Die Messung der drei letztgenannten Veränderungen erfolgte vergleichend bei untrainierten Versuchspersonen und Hochleistungssportlern. Dabei zeigten die Sportler während einer Standardbelastung von 150 Watt hinsichtlich der Gerinnung und Fibrinolyse geringere Aktivitätssteigerungen als die Untrainierten gleichen Alters. Während maximaler Belastung glichen sich die Werte beider Versuchsgruppen weitgehend an.
    Type of Medium: Electronic Resource
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