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  • 1
    Electronic Resource
    Electronic Resource
    Aneurysms of the coronary arteries in infants and children (1977)
    Springer
    Virchows Archiv 374 (1977), S. 27-44 
    Details
    ISSN: 1432-2307
    Keywords: Coronary artery aneurysms ; Mucocutaneous lymph node syndrome ; Kawasaki's disease ; Infantile polyarteritis nodosa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In recent years large numbers of the so-called “mucocutaneous lymph node syndrome” or “Kawasaki's disease” have been described by Japanese workers, but instances of this disorder are only now being reported as isolated cases by European or North American physicians. The disease has, therefore, been considered to be a new entity. One of its most striking features is the development of aneurysms of the coronary arteries in infants or children, which may lead to sudden death. Aneurysms of the coronary arteries in childhood are rare, and hence it was considered relevant to report six such cases, and to examine their possible relationship to Kawasaki's disease. The pathological changes underlying the latter disorder are not well known; they are considered to be indistinguishable from infantile polyarteritis nodosa. A diagnosis of polyarteritis nodosa was also thought to be most likely to apply in the cases presented here, particularly in view of the frequency with which aneurysms of the coronary arteries have been found in this disorder. In the absence of valid pathological distinctions between Kawasaki's disease and infantile polyarteritis nodosa, the question arises whether these entities are, in fact, different, and whether Kawasaki's disease is the new entity it is assumed to be.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430568
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  • 2
    Electronic Resource
    Electronic Resource
    Suicide and homicide: Common sources and consistent relationships (1977)
    Springer
    Social psychiatry and psychiatric epidemiology 12 (1977), S. 149-156 
    Details
    ISSN: 1433-9285
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study reappraises Lester's (1971) multiple replication of suicide-homicide correlations, which determined that there is no clear pattern of relationship and thus that sociological theory could contribute little to an understanding of suicidal and homicidal behavior. However, additional steps are required to complete Lester's analyses, including (1) correction of time-series calculations for serial correlation, (2) correction of cross-state calculations for nonwhites by removing states with very small nonwhite populations, and (3) correction of crossmarital status calculations by segmenting according to race. With these necessary corrections, there is generally a positive association between suicide and homicide rates in the United States. Subculture of violence and anomie theories of homicide and suicide are strongly supported and can be extended to both forms of behavior. This suggests a general sociological dimension of predisposition to lethal violence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00578974
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  • 3
    Electronic Resource
    Electronic Resource
    Factors influencing blood concentrations of chlordiazepoxide: A use of multiple regression analysis (1977)
    Springer
    Psychopharmacology 54 (1977), S. 277-282 
    Details
    ISSN: 1432-2072
    Keywords: Chlordiazepoxide ; Benzodiazepines ; Blood concentrations ; Pharmacokinetics ; Regression analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Three groups of male and female subjects aged 24–74 years received 25, 100, or 200 mg of chlordiazepoxide hydrochloride by mouth as a single dose or as two divided doses. The relation of plasma or whole blood concentrations for chlordiazepoxide (CDX) and its metabolite, desmethylchlordiazepoxide (DMCDX), to time since the last dose, weight, age, and sex were determined by simple and multiple regression analyses. Both CDX and DMCDX levels were negatively correlated with weight. Concentrations of CDX decreased, while those of DMCDX increased, with the time since the last dose. Lower levels of both drugs were associated with female sex, and lower levels of DMCDX were noted with increasing age. In the largest sample group, age and weight were more important variables than sex in accounting for CDX and DMCDX. Sex was of significance, and more important than time or age in explaining the variance of CDX in one series of observations. Multiple regression analysis is a useful approach to assessing interrelated factors influencing blood levels of drugs, especially when combined with a consideration of the interactive components of variance. Age and sex, in addition to weight and time, may be important factors that deserve further attention.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426576
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  • 4
    Electronic Resource
    Electronic Resource
    Lengths and patterns of transcriptional units in the amplified nucleoli of oocytes of Xenopus laevis (1977)
    Springer
    Chromosoma 60 (1977), S. 147-167 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Transcriptionally active chromatin from peripheral amplified nucleoli of lampbrush-chromosome stage oocytes of Xenopus laevis was dispersed and spread in various solutions of low salt concentrations (including some with additions of detergents) and examined by electron microscopy. Nucleolar material from oocytes of animals with normal (2-nu) and mutant (1-nu) genetical constitution of nucleolus organizers was compared. Histograms showing the distributions of the lengths of matrix units, apparent spacer intercepts, and the total repeating units of the rDNA containing chromatin axes revealed a significant degree of heterogeneity, with indications of subclasses and predominant repeat unit size classes of 3.3 and 3.8 μm length. The correspondence of matrix unit length to the molecular weight of the first stable product of rDNA transcription was studied using gel electrophoresis of labelled pre-rRNA under non-denaturing and denaturing conditions. Evaluations of individual strands of nucleolar chromatin further demonstrated the existence of both (i) strands with obviously homogeneous repeating units and (ii) strands with intra-axial heterogeneity of rDNA subunits. “Preludecomplexes”, i.e. groups of transcriptional complexes in apparent spacer intercepts, were not infrequently noted. The data are compared with the measurements of lengths of repeating units in fragments of rDNA obtained by digestion with EcoRI endonuclease as described by Morrow et al. (1974) and Wellauer et al. (1974, 1976a, b). The results are discussed in relation to problems of variations in the modes of arrangement of the pre-rRNA genes, the state of packing of rDNA during transcription, and possible mechanisms of the amplification process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00288462
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  • 5
    Electronic Resource
    Electronic Resource
    Fourth symposium onAcetabularia (1977)
    Springer
    Protoplasma 91 (1977), S. 221-228 
    Details
    ISSN: 1615-6102
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01276737
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  • 6
    Electronic Resource
    Electronic Resource
    Stability of string type solutions in classical gauge field theories (1977)
    Springer
    Theoretical and mathematical physics 31 (1977), S. 471-475 
    Details
    ISSN: 1573-9333
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01030562
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  • 7
    Electronic Resource
    Electronic Resource
    101. Zur Problematik der konservativen Gallensteinauflösung unter chirurgischer Sicht (1977)
    Springer
    Langenbeck's archives of surgery 345 (1977), S. 583-583 
    Details
    ISSN: 1435-2451
    Keywords: CDC ; Gallstones, cholesterol, surgical treatment ; CDS ; Gallensteine ; Chirurgische Behandlung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: ZusammenfaBung Reine Cholesterinsteine können mit Chenodesoxycholsäure aufgelöst werden. 208 konsekutiv gewonnene Gallensteine wurden untersucht. 93,7% enthielten Cholesterin, aber nur 10,3% waren reine Cholesterinsteine. Röntgenologisch ist eine Verifizierung zwischen reinen Cholesterinsteinen und Cholesterinsteinen mit geringem Calciumgehalt nicht möglich. Unter der Behandlung mit CDS kommt es zu einem Anstieg der Transaminasen, zu cholagenen Durchfällen und zur verstärkten Bildung von der lebertoxischen Lithocholsäure. Nach Absetzen der CDSBehandlung wird regelmäBig eine Rezidivsteinbildung beobachtet.
    Notes: Summary Pure cholesterolgallstones can be diBolved by chenodesoxycholic acid (CDC). The composition of 208 gallstones was examined: 93.7% contained cholesterol, but only 10.6% were pure cholesterol stones. Radiologically no differentiation between pure cholesterolgallstones and mixed stones with a low calcium content was poBible. With CDC there is an increase of liver enzymes, choleraic diarrhea, and hepatotoxic lithocholic acid. As a rule, recurrent stones are observed after discontinued treatment with CDC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01305545
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  • 8
    Electronic Resource
    Electronic Resource
    Freeze-fracture aspects of the junctional complexes in the round window membrane (1977)
    Springer
    European archives of oto-rhino-laryngology and head & neck 217 (1977), S. 331-337 
    Details
    ISSN: 1434-4726
    Keywords: Freeze-fracture ; Electron microscopy ; Zonulae occludentes ; Gap junctions ; Round window membrane ; Gefrierbruchmethode ; Elektronenmikroskopie ; Zonulae occludentes ; Gap junctions ; Runde-Fenster-Membran
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Untersuchung der Runde-Fenster-Membran des Chinchillas mit Hilfe der Gefrierbruchmethode. Zonulae occludentes werden morphologisch sowohl zwischen den Zellen der tympanalen Lage als auch zwischen denen der perilymphseitigen Zellschicht nachgewiesen. “Gap junctions” verbinden — nach bisherigen Befunden — lediglich die perilymphatischen Zellen.
    Notes: Summary Replicas of the freeze-fractured round window membrane were studied in chinchillas. Morphologically identifiable zonulae occludentes were found between the cells facing the tympanic cavity and between the cells bordering the perilymphatic space. Gap junctions were only found between the perilymphatic cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00465550
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  • 9
    Electronic Resource
    Electronic Resource
    Elektronenmikroskopische Befunde der Membran des Runden Fensters (1977)
    Springer
    European archives of oto-rhino-laryngology and head & neck 216 (1977), S. 522-522 
    Details
    ISSN: 1434-4726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00458945
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  • 10
    Electronic Resource
    Electronic Resource
    Umwandlung von Cycloolefinen in Gegenwart von Ethylbromid und Alkylaluminiumverbindungen (1977)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1977 (1977), S. 1862-1873 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Reactions of Cycloolefins in the Presence of Ethyl Bromide and Alkylaluminium CompoundsIf cyclohexene (1) is added below 100°C to a mixture of ethyl bromide (2) and diethylaluminium bromide (3), ethylene is formed as vent gas and ethylcyclohexane (6), 1,1-diethylcyclohexane (7), ethylbicyclohexyl 8, bicyclohexyl (9), and higher molecular products of 1 can be isolated. - In the mixture of 2 and 3, and in the presence of an excess of triethylaluminium (5), compound 1 is substituted to give ethylcyclohexene and ethane as vent gas. Cyclooctene, cyclooctadiene, and 3a,4,7,7a-tetrahydro-4,7-methanoindene are ethylated and hydrogenated, the latter by opening of the methylene bridge to form 4-methylhydrindan.
    Notes: Gibt man unterhalb 100°C Cyclohexen (1) zur Mischung von Ethylbromid (2) und Diethylaluminiumbromid (3), so entstehen - unter Abspaltung von Ethylen - Ethylcyclohexan (6), 1,1-Diethylcyclohexan (7), Ethylbicyclohexyl 8, Bicyclohexyl (9) und höhermolekulare Produkte aus 1. - In Gegenwart von überschüssigem Triethylaluminium (5) wird 1 in der Mischung von 2 und 3 bevorzugt unter Abgabe von Ethan zu Ethylcyclohexen substituiert. Cycloocten, Cyclooctadien und 3a,4,7,7a-Tetrahydro-4,7-methanoinden werden hauptsächlich ethyliert und hydriert, letzteres unter Öffnung der Methylenbrücke zu 4-Methyl-hydrindan.
    Additional Material: 5 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.197719771108
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