ISSN:
1432-1041
Keywords:
chlorpromazine
;
sperm motility
;
central nervous system depressant
;
caffeine
;
membrane stabilizing effect
;
fertility
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The in vitro effects of chlorpromazine, diazepam, phenytoin and phenobarbitone on human sperm motility were investigated. Only chlorpromazine inhibits human sperm motility and the concentration which decreases sperm motility to 50% of control is 0.22 mM. Caffeine can shift the dose-response curve of chlorpromazine-inhibited sperm motility to right. We support the hypothesis that chlorpromazine acts on the cellular membrane but consider the inhibition of sperm motility an unlikely cause of decreased fertility in chlorpromazine treated patients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00542545
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