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  • Electronic Resource  (5)
  • 2000-2004  (2)
  • 1985-1989  (3)
  • 2003  (2)
  • 1988  (3)
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  • Electronic Resource  (5)
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  • 2000-2004  (2)
  • 1985-1989  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    Elevated Serum Heat-Shock Protein 70 Levels in Patients with Acute Infection: Use of an Optimized Enzyme-Linked Immunosorbent Assay (2003)
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 58 (2003), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Heat-shock proteins (Hsps) are highly conserved throughout evolution and evoke great interest both in basic biology and in medicine. They are expressed in small quantities under normal conditions, and their expression can be strongly induced by several stressors. Although their action is basically intracellular, it is now obvious that these proteins can be released into the extracellular environment from viable cells. In this study, the human Hsp 70 serum concentrations were determined using an optimized, cost-effective enzyme-linked immunosorbent assay (ELISA). The average intra-assay variation was 6%, whereas the average interassay variation was 9%. The sensitivity of the assay was 10 ng/ml, and spiking experiments showed recoveries between 101 and 109%. As an application of the technique, we have investigated the serum levels of human Hsp 70 in patients with infection and in healthy subjects. Our data show significantly higher levels of Hsp 70 (P  = 0.003) in patients compared to control subjects. Positive correlations were noticed between the serum levels of Hsp 70 and various markers of inflammation (IL-6; r = 0.579, P = 0.009, TNF-α; r  = 0.552, P  = 0.012, IL-10; r  = 0.361, P = 0.002). We conclude that Hsp 70 is involved in inflammation of infectious origin. The interindividual variation in the serum concentration of Hsp 70 precludes the use of serum Hsp 70 levels to distinguish patients from healthy subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.2003.01341.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Selective defoliation by sheep according to slope and plant species in the hill country of New Zealand (2003)
    Oxford, UK : Blackwell Science Ltd
    Grass and forage science 58 (2003), S. 0 
    Details
    ISSN: 1365-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The objective of the study was to evaluate the grazing behaviour by sheep in hill country paddocks in New Zealand which had received two long-term fertilization and stocking rate treatments [high fertility–high stocking rate (HH); low fertility–low stocking rate (LL)]. Herbage accumulation and selective grazing were evaluated within low slope (LS), medium slope (MS) and high slope (HS) categories. Transects lines were placed and tillers of Agrostis capillaris and Lolium perenne in the LS category; A. capillaris, Anthoxanthum odoratum and L. perenne in the MS category; and A. capillaris and A. odoratum in the HS category were marked. The leaf length of each marked tiller was measured and used to determine selective grazing over 3 weeks during each season. The highest herbage accumulation rates were during spring and the lowest in summer and winter. The LS category showed the highest herbage accumulation rates and HS the lowest. Except for autumn, the marked tillers were more frequently grazed in the HH than in the LL paddock. During summer, autumn and spring, grazing frequency in the slope categories was in the order LS 〉 MS 〉 HS. During winter sheep did not discriminate between slope category. During summer, autumn and spring, sheep did not selectively graze the species studied but this was not the case during winter. Overall, sheep selectively grazed L. perenne. In all the seasons L. perenne consistently had the longest leaves but within species there was no consistent relationship between leaf length and probability of being grazed. Selective grazing changed through the year according to herbage accumulation rate. Sheep concentrated grazing in the category LS when herbage accumulation rate was high, but they did not discriminate between slope categories in winter when herbage accumulation rate was low.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2494.2003.00386.x
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  • 3
    Electronic Resource
    Electronic Resource
    Deletion proximal to DXS68 locus (L1 probe site) in a boy with Duchenne muscular dystrophy, glycerol kinase deficiency, and adrenal hypoplasia (1988)
    Springer
    Human genetics 〈Berlin〉 78 (1988), S. 222-227 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We report a case of a boy with Duchenne muscular dystrophy (DMD) associated with GK deficiency (GK), congenital adrenal hypoplasia (AHC), and mental retardation. Cytogenetic analysis of prometaphasic chromosomes revealed an interstitial chromosome deletion at Xp21.2 possibly extending to Xp21.1 or Xp21.3. His phenotypically normal mother was heterozygous for this deletion. DNA probe analysis on Southern blots showed that the deletion affected the following probe sites: 754, pERT 84, 21A, XJ2.3, pERT 87, JBir, and J66-H1, whereas L1, C7, and CX5.4 probes gave a normal signal. Pulse field gel electrophoresis after SfiI digestion did not show abnormal fragments with L1. These data are consistent with a deletion of about 4 megabases and indicate that the GK and AHC loci are proximal to L1 and distal to J66-H1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291665
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Phosphatidylcholine synthesis in isolated type II pneumocytes from ozone-exposed rats (1988)
    Springer
    Archives of toxicology 61 (1988), S. 224-228 
    Details
    ISSN: 1432-0738
    Keywords: Ozone ; Phosphatidylcholine synthesis ; Alveolar type II cells ; Pulmonary surfactant ; Rat lung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Phosphatidylcholine (PC) synthesis by alveolar type II cells, as an indicator for the production of pulmonary surfactant, was studied after a 4-h exposure of rats to 4 mg ozone/m3 (2 ppm). Lung ravage fluid analysis after exposure revealed significant increases in proteins, which is indicative for pulmonary injury. When type II cells were isolated immediately and thereafter cultured for 20 h, the rate of PC synthesis in cells derived from ozone-exposed rats was not significantly different from that in cells from unexposed controls. Yet, a decreased rate of PC synthesis was observed when these cells were subsequently exposed to ozone in vitro. The activity of the enzyme glycerolphosphate acyltransferase (GPAT) was slightly enhanced in cultured type II cells isolated from ozone-exposed rats, while the lysophosphatidylcholine acyltransferase (LPCAT) activity was unchanged. However, ozone exposure of rats did result in a significant decrease of PC synthesis when measured in freshly prepared type II cell suspensions, although both GPAT and LPCAT activities were not affected. It is concluded that a decrease in pulmonary surfactant related PC synthesis after ozone exposure of rats can be demonstrated in freshly isolated type II pneumocytes. Cultured type II cells from exposed rats lack this effect and are therefore less useful to study changes in phospholipid biosynthesis after in vivo ozone exposure. The data on in vitro ozone exposure of cultured type II cells, however, support the view that ozone may impair pulmonary surfactant production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00316638
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  • 5
    Electronic Resource
    Electronic Resource
    Hemidiaphragmatic paralysis, an unusual presentation of Parsonage-Turner syndrome (1988)
    Springer
    Clinical rheumatology 7 (1988), S. 402-405 
    Details
    ISSN: 1434-9949
    Keywords: Parsonage-Turner Syndrome ; Hemidiaphragmatic Paralysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A previously healthy 38-year-old man presented a typical Parsonage-Turner syndrome (PTS) three weeks after a cold and unusual muscular exercise. In addition to the motor and sensory defects of the upper limbs, a right hemidiaphragmatic paralysis occurred, which proved to be reversible after several months. A brief review of the hemidiaphragmatic injury in PTS is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02239201
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