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  • Electronic Resource  (3)
  • 2000-2004  (3)
  • 1980-1984
  • 2000  (3)
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  • Electronic Resource  (3)
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  • 2000-2004  (3)
  • 1980-1984
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  • 1
    Electronic Resource
    Electronic Resource
    Induction of neurogenesis in the neocortex of adult mice (2000)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 405 (2000), S. 951-955 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Neurogenesis normally only occurs in limited areas of the adult mammalian brain—the hippocampus, olfactory bulb and epithelium, and at low levels in some regions of macaque cortex. Here we show that endogenous neural precursors can be induced in situ to differentiate into mature ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35016083
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    A one-hit model of cell death in inherited neuronal degenerations (2000)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 406 (2000), S. 195-199 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In genetic disorders associated with premature neuronal death, symptoms may not appear for years or decades. This delay in clinical onset is often assumed to reflect the occurrence of age-dependent cumulative damage. For example, it has been suggested that oxidative stress disrupts ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35018098
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    New chemotherapeutics in malignant mesothelioma: effects on cell growth and IL-6 production (2000)
    Springer
    Cancer chemotherapy and pharmacology 45 (2000), S. 502-508 
    Details
    ISSN: 1432-0843
    Keywords: Key words Malignant mesothelioma ; Chemotherapy ; Gemcitabine ; Irinotecan ; Interleukin-6
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: The benefits of chemotherapy can be assessed in terms of tumour shrinkage, prolongation of life or simply palliation of symptoms. In the study reported here, in vitro correlates of these parameters were sought as a rational guide to the choice of newer agents in the clinic. Methods: The cytotoxicity and effects on IL-6 production of ten chemotherapy agents representing four different classes of drugs were tested against a panel of five mesothelioma cell lines. Results: The mesothelioma cells were more sensitive to the action of irinotecan (and its active metabolite SN38) and gemcitabine than the control cell lines. Gemcitabine and to a lesser extent irinotecan inhibited the secretion of the proinflammatory cytokine IL-6 at concentrations of each drug that produced only small decreases in cell viability. This effect was not seen in cells treated with docetaxel or vindesine. Higher doses of gemcitabine and irinotecan caused a surge in IL-6 release and this was not due to release of intracellular stores of IL-6 through lysis of the cells. Conclusions: These results suggest that irinotecan and gemcitabine are not only more likely to be active against mesothelioma than other new chemotherapy agents but may also produce a palliative effect in nonresponders to these agents by decreasing the secretion of IL-6.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800051026
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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