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  • 1
    Electronic Resource
    Electronic Resource
    Stage-specific and opposing roles of BDNF, NT-3 and bFGF in differentiation of purified callosal projection neurons toward cellular repair of complex circuitry (2004)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 19 (2004), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Cellular repair of neuronal circuitry affected by neurodegenerative disease or injury may be approached in the adult neocortex via transplantation of neural precursors (“neural stem cells”) or via molecular manipulation and recruitment of new neurons from endogenous precursors in situ. A major challenge for potential future approaches to neuronal replacement will be to specifically direct and control progressive differentiation, axonal projection and connectivity of neural precursors along a specific neuronal lineage. This goal will require a progressively more detailed understanding of the molecular controls over morphologic differentiation of specific neuronal lineages, including neurite outgrowth and elongation, in order to accurately permit and direct proper neuronal integration and connectivity. Here, we investigate controls over the morphologic differentiation of a specific prototypical lineage of cortical neurons: callosal projection neurons (CPN). We highly enriched CPN to an essentially pure population, and cultured them at three distinct stages of development from embryonic and postnatal mouse cortex by retrograde fluorescence labelling, followed by fluorescence-activated cell sorting. We find that specific peptide growth factors exert direct stage-specific positive and negative effects over the morphologic differentiation and process outgrowth of CPN. These effects are distinct from the effects of these growth factors on CPN survival [Catapano et al. (2001)J. Neurosci., 21, 8863–8872]. These data may be critical for the future goal of directing lineage-specific neuronal differentiation of transplanted or endogenous precursors/“stem cells” toward cellular repair of complex cortical circuitry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0953-816X.2004.03303.x
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  • 2
    Electronic Resource
    Electronic Resource
    Neurobiology New memories from new neurons (2001)
    [s.l.] : Nature Publishing Group
    Nature 410 (2001), S. 314-317 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] There is a long-standing dogma that the brains of adult mammals do not generate new nerve cells. Yet data to the contrary have existed for over 35 years, and more recent results have brought general acceptance that neurons are indeed born in the adult mammalian brain — but only in two ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35066661
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Induction of neurogenesis in the neocortex of adult mice (2000)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 405 (2000), S. 951-955 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Neurogenesis normally only occurs in limited areas of the adult mammalian brain—the hippocampus, olfactory bulb and epithelium, and at low levels in some regions of macaque cortex. Here we show that endogenous neural precursors can be induced in situ to differentiate into mature ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35016083
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    Paper (German National Licenses)
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