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  • Electronic Resource  (4)
  • 2005-2009
  • 1985-1989  (2)
  • 1975-1979  (2)
  • Cannabis  (2)
  • Oxalates  (2)
Source
Material
  • Electronic Resource  (4)
Years
  • 2005-2009
  • 1985-1989  (2)
  • 1975-1979  (2)
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Studies on the interactions of copper and cannabis (1978)
    Springer
    Psychopharmacology 56 (1978), S. 309-316 
    Details
    ISSN: 1432-2072
    Keywords: Cannabis ; Copper ; Interactions ; Hypothermia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The action of copper (CuSO4, 5mg/kg, oral) on selected neuropharmacological actions of cannabis resin (CI, oral) was studied on albino rats and mice. Copper potentiated the barbiturate hypnosispotentiating activity of CI in albino rats and mice and had no effect on hypothermic activity in albino rats. Single doses of copper partially inhibited tolerance to barbiturate hypnosis-potentiation activity and markedly delayed the development of tolerance to hypothermic activity of CI. Oral as well as i.c.v. copper (CuSO4, 0.1 μg) in single dose antagonised the tolerance to hypothermic activity of cannabis or THC for to two weeks. Copper-CI interaction could be antagonised by penicillamine. Zinc (ZnSO4, 5 mg/kg, oral) had an action similar to that of copper in antagonising the development of tolerance to the hypothermic activity of CI, but magnesium (MgSO4, 5 mg/kg, i.p.) was devoid of any such action. Studies indicate that, although copper has no significant neuropharmacological action, it interacts with CI activity, especially in tolerant rats, in effects on hypothermia. The site of action of copper is possibly the hypothalamus, where it inhibits the processes of tolerance development to CI on the noradrenergic neurone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432855
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Sodium is neither a risk nor a protective factor in urolithiasis? (1987)
    Springer
    Urological research 15 (1987), S. 105-108 
    Details
    ISSN: 1434-0879
    Keywords: Sodium ; Inhibitory activity ; Oxalates ; Phosphates ; Calcium ; Calculi
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary the effect of changes in urinary sodium, induced by dietary manipulation in normal subjects (NS) and in stone formers (SF) was studied by observing crytalluria qualitatively and by determining calcium, oxalate and phosphate crystallization quantitatively in an experimental model. In SF the calcium crystallization was significantly higher than in NS at all the three levels of urinary sodium studied. However, no difference was observed in oxalate and phosphate crystallization rates between these two groups. Calcium and oxalate (p〈 0.05) and oxalate and phosphate (p〈 0.001) were found to be correlated in NS but were non-significant in SF. The wide changes in the urinary sodium induced by dietary changes did not influence the crystallization rate of calcium, nor of oxalate and phosphate in NS as well as in SF. The results suggested that a sodium intake with lower and upper limits of 124 mg and 6,009 mg respectively did not act as “inhibitor” of crystallization rate nor did it induce hypercalciuria severe enough to pose a “risk” of stone formation. The results did not suggest that a high urinary sodium increases the solubility of calcium phosphate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00260942
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Urinary biochemical profile of patients with ureteric calculi in Jodhpur region (north western India) (1988)
    Springer
    Urological research 16 (1988), S. 105-110 
    Details
    ISSN: 1434-0879
    Keywords: Ureteric stone formers ; Urine chemistry ; Oxalates ; Calcium ; Risk index ; Ion activity product
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Urine chemistry of 42 normal subjects (NS) and 59 ureteric stone formers (SF) from Jodhpur region of Rajasthan, India is presented. Twenty four hour urinary levels of calcium, oxalic acid and uromucoids were significantly higher and levels of magnesium, citric acid and inorganic phosphorus were significantly lower in SF as compared to NS. No significant difference was observed in the uric acid, sodium and potassium levels in the two groups. Significant correlation was observed between calcium and magnesium; calcium and oxalic acid; calcium and citric acid; magnesium and oxalic acid; and oxalic acid and citric acid in NS on the basis of mmol/l but not on the basis of mmol/24 h. Calcium and oxalic acid correlation was uninfluenced by magnesium and citric acid levels. The log of risk factor index (RI) was higher (p〈 0.001) in SF (−1.652) as compared to NS (−2.103). The log of ion activity product (IAP) was also higher (p〈 0.001) in SF (−3.192x10−3) than in NS (−2.914x10−1). Based on RI and IAP, a scale has been devised for the prediction of the risk of stone formation and recurrence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00261966
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Role of catecholamines in the hypothermic activity of cannabis in albino rats (1976)
    Springer
    Psychopharmacology 50 (1976), S. 199-204 
    Details
    ISSN: 1432-2072
    Keywords: Cannabis ; Hypothermia ; Catecholamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Role of brain monoamines in the hypothermic activity of cannabis resin (CI) in albino rats was studied using agents which influence monoamine synthesis, storage, release, reuptake, metabolism and receptor activity and monoaminergic neuronal activity. Delta-9-tetrahydrocannabinol content of resin was estimated to be 17%. Reserpine was used for comparison. CI was given orally in the dose of 50 mg/kg. Nialamide (NM) and α-methyl-metatyrosine (MMT) caused slight hyperthermia. p-Chlorophenylalanine (PCPA), α-methyl-p-tyrosine (MPT), 5,6-dihydroxytryptamine (DHT, icv) and 6-hydroxydopamine (6-HD, icv) had no effect on body temperature. α-Methyldopa (m-Dopa), diethyldithiocarbamate (DDC), DDC with l-Dopa, gammabutyrolactone (GBL), phentolamine (PHENT), phenoxybenzamine (PBZ), propranolol (PROP) and imipramine (IMP) produced hypothermia. Hypothermic activity of CI was potentiated by NM and PCPA, unaffected by DHT and m-Dopa, blocked by MMT, MPT, 6-HD, GBL, PHENT, PROP and chlorpromazine (CPZ), inhibited by DDC, DDC and l-Dopa and PBZ. CI induced hyperthermia in tolerant rats could be reversed to hypothermia by IMP. Reserpine hypothermia was blocked by NM, MPT, 6-HD and CPZ. There was a partial cross tolerance between cannabis and reserpine. Studies indicate that the hypothermic activity of CI similar to that of reserpine is mediated through central catecholamines and not 5-HT, and that noradrenaline is involved and not dopamine. However, the mechanism of action of cannabis and reserpine on nor-adrenergic neurone seems to be different.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430493
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    Paper (German National Licenses)
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