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  • Electronic Resource  (5)
  • 2005-2009  (3)
  • 1970-1974  (2)
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  • Electronic Resource  (5)
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  • 1
    Electronic Resource
    Electronic Resource
    160
The Selective Anti-Inflammatory Activity of Prolonged Release Nanocrystalline Silver Dressing (Acticoat 7®) in the Treatment of Chronic Venous Leg Ulcers (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The treatment of venous ulcers must start with compression and if the ankle brachial index is greater than 0.8 high compression bandages can be applied. Despite edema control, there are a number of venous ulcers that do not heal at the expected rate. Patients with venous ulcers of greater than 4 weeks duration were treated with a prolonged release absorptive nanocrystalline silver dressing (Acticoat 7) under the 4 layer bandage, Profore for 12 weeks, or until healing. Biopsies were obtained from the ulcer base at week 0 for histology and bacterial burden. Duplicate biopsies for quantitative bacteriology were performed with one submitted whole and the second bisected into superficial and deep components. The paired biopsies were then repeated after a median of 6.5 weeks (range 2 to 12 weeks). The histological specimens were examined by the histopathologist (SR). Inflammatory infiltrates were identified in the superficial, middle and deep segments of the biopsies. Acute infiltrates were identified through the concentration of neutrophils and chronic infiltrates by the presence of lymphocytes. Each biopsy and each segment was graded for infiltrates on a four point semi quantitative score. A total of 15 patients (9 male, and 6 female) were enrolled into the study. The median age was 63 years (range 30–83 years). The median duration of current ulceration was 17.3 weeks (range 4 weeks to 11 years) and the median ulcer area was 4.8 cm2(range 1.8–43.9 cm2). The median exposure to Acticoat 7 was 82 days (range 8–86 days).There were 12 sets of paired biopsies that were analyzed. There was a statistically significant reduction (p = 0.0114) in the log10(total bacterial count) between the baseline and final biopsies (median 4.48 and 3.00, respectively). Four patients healed, 8 patients continued to the end of the 12-week study period and three patients were discontinued early. For all patients, the median percentage reduction in ulcer area was 94.4% and the median final ulcer area was 0.4 cm2. Analysis of the histology and bacteriology data demonstrated that the presence of a high neutrophilic infiltrate in skin biopsies was associated with high bacterial counts (superficial compartment of the quantitative biopsies) at week 4 and delayed healing (p = 0.037). In the week 0 biopsy, increased lymphocytic infiltrates within the superficial and middle segments were associated with accelerated healing in the first 4 weeks (p = 0.26 and 0.09). The nanocrystalline silver dressing has demonstrated an anti-bacterial and permissive but selective anti-inflammatory action allowing lymphocytic infiltrates to increase associated with an accelerated reduction in ulcer size.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130216bl.x
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  • 2
    Electronic Resource
    Electronic Resource
    144
Effects of a Silver Hydrofiber® Dressing on the Quantitative Bacterial Burden, Reduction in Ulcer Size and Exudate of Chronic Non-Healing (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Often chronic wounds have an increased bacterial burden that can impair healing without the classical clinical signs of infection. Silver dressings may provide an alternative topical method to control bacterial burden.The primary aim of this study was to evaluate the effect of 2–4 weeks therapy with the Silver Containing Hydrofiber® dressing on quantitative bacterial burden and clinical improvement in chronic wounds not healing at the expected rate.This was a single centre, four-armed study which included a total of 30 patients with diabetic foot ulcers, leg ulcers, pressure ulcers and miscellaneous wounds that did not fit into any of the above categories. Patients had a baseline quantitative bacterial biopsy and this was repeated at weeks 2 to 4. The wound size was recorded along with a semi quantitative estimate of exudate and the periwound temperatures. Repeat measurements were performed at the follow-up visits and the decrease in wound size calculated. The underlying cause of the ulceration was be treated and corrected. This was followed by application of silver containing hydrofiber® dressing. There was a significant delay in healing of the leg ulcers associated with increased bacterial burden in the quantitative biopsy bacterial burden results at week 0 and healing at week 2. (p = 0.01). Other subgroups had a similar association that did not reach statistical significance. The presence of an increased exudate in the leg ulcers at week two was associated with delayed healing at week 4 (p = 0.05). There was also a significant increase in skin surface temperature of the surrounding skin with an increased quantitative bacterial biopsy of the deep wound compartment for venous, diabetic neurotrophic foot ulcers and pressure ulcers with p values of 0.05, 0.01 and 0.01 respectively. There was no significant decrease in exudate or increased healing of the wounds with the application of the silver hydrofiber dressing in this difficult to heal population. The population studied in this case series had increased bacterial burden in the deep compartment as measured with increased exudate and or an increased temperature of the periwound skin. These patients have an increased bacterial burden in the deep wound compartment that does not respond to topical ionized silver in the dressing studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130216av.x
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  • 3
    Electronic Resource
    Electronic Resource
    140 Open Label Pilot Study of Prolonged Release Nanocrystalline Silver Dressing (Acticoat 7): Reduction of Bacterial Burden Treatment in the Treatment of Chronic Venous Leg Ulcers (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In persons with venous ulcers and an absence of arterial disease, high compression as exemplified by the four layer bandage (Profore) has been demonstrated to be effective by a meta-analysis of existing studies. Despite optimized compression, some venous ulcers do not heal at the expected rate and persistent inflammation or infection may delay or prevent healing. We report the results of a case series that demonstrates an ionized silver dressing with prolonged release of nanocrystalline crystals (Acticoat 7) can decrease bacterial burden and accelerate healing in venous ulcers not healing at the expected rate. Patients with venous ulcers were treated with a prolonged release absorptive nanocrystalline silver dressing (Acticoat 7) under a four layer bandage (Profore) for 12 weeks, or until healing. The primary efficacy objective measured the effect of the silver dressing on the wound microflora. Biopsies of the wounds were taken at baseline and after treatment with the silver dressing (Acticoat 7) and were analyzed for the bacterial species and number of bacteria present. In addition, serum silver levels were assessed at baseline, weeks 4, 8 and week 12 or final assessment. A total of 15 patients (9 male, and 6 female) were enrolled into the study. The median age was 63 years (range 30–83 years). The median duration of current ulceration was 17.3 weeks (range 4 weeks to 11 years) and the median ulcer area was 4.8 cm2(range 1.8–43.9 cm2). The median exposure to Acticoat 7 was 82 days (range 8–86 days). There was a statistically significant reduction (p = 0.0114) in the log10(total bacterial count) between the baseline and final biopsies (median 4.48 and 3.00, respectively). Four patients healed, 8 patients continued to the end of the 12-week study period and three patients were discontinued early. Of those patients who did not heal, 4 had more than a 94% reduction in wound area by the end of the 12-week study period. For all patients, the median percentage reduction in ulcer area was 94.4% and the median final ulcer area was 0.4 cm2. Statistical analysis showed a significant increase (p = 0.054) in serum silver concentration during the treatment period. At baseline, prior to the silver dressing treatment (Acticoat 7), the median silver concentration was 0.3 μg/L (range: 0.20–1.90 μg/L). The median within patient change from baseline serum silver concentration was an increase of 0.15 μg/L (range: −0.3–2.8 μg/L). Although this small increase was observed it was not considered clinically significant. This study illustrates the use of prolonged release nanocrystalline silver dressing to decrease the bacterial burden of chronic venous ulcers not healing at the expected rate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130216ar.x
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  • 4
    Electronic Resource
    Electronic Resource
    Cobalt zoning in microscopic pyrite from Kamoto, Republic of the Congo (Kinshasa) (1971)
    Springer
    Mineralium deposita 6 (1971), S. 167-176 
    Details
    ISSN: 1432-1866
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Resume Le gisement de Kamoto est constitué de deux corps minéralisés stratiformes séparés par une unité sédimentaire stérile. C'est un gisement de cuivre et de cobalt dont les principales caractéristiques sont brièvement résumées. Audessus du corps minéralisé supérieur, on trouve des couches de dolomie, où la pyrite est le seul sulfure présent. Cette pyrite a été étudiée à l'aide d'une microsonde: tous les grains idiomorphes y sont entourés d'une bordure bien nette, où la teneur en cobalt atteint 4%; les grains d'apparence framboïdale sont également hétérogènes au point de vue de leur teneur en cobalt. La distribution du nickel et du cuivre est décrite. Ces observations apportent um témoignage supplémentaire de l'importance des événements postérieurs au dépôt dans la «Série des Mines» katangaise, tout spécialement en ce qui concerne la géochimie des métaux lourds. Elles démontrent que le «système» constitué par la roche sédimentaire est resté ouvert pendant un certain temps après la sédimentation.
    Notes: Abstract The Kamoto deposit consists of two stratiform orebodies separated by a barren sedimentary unit. It is a copper and cobalt deposit, the main features of which are summarized in the first part of the paper. Above the upper orebody, dolostone beds are found, where pyrite is the only sulfide mineral. This pyrite was investigated with the help of a microprobe: all idiomorphic grains were found to be surrounded by a well-defined rim, where the cobalt content reaches 4%; framboidal grains were also found to be heterogeneous with respect to cobalt. The distribution of nickel and copper is described. These observations afford one more evidence that post-depositional events played an important role in the “Mine Series” of Katanga, especially with regard to heavy metals geochemistry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00208027
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  • 5
    Electronic Resource
    Electronic Resource
    Pancreatico-duodenal allotransplantation: Experimental and clinical experience (1970)
    Springer
    Acta diabetologica 7 (1970), S. 909-989 
    Details
    ISSN: 1432-5233
    Keywords: Diabetes ; Duodenum ; Kidney ; Pancreas ; Rejection ; Transplant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Il a été mis au point une méthode de laboratoire pour l'allogreffe pancréatico-duodénale chez le chien pancréatectomisé. Les animaux chez lesquels de telles greffes ont été pratiquées ont survecu plusieurs mois, si on les a traités avec azathioprine et prednisone afin de prévenir le rejet. Contrairement à ce que l'on pense généralement, le pancréas n'est pas particulièrement sensible à l'ischémie totale, étant donné qu'il y a été possible de conserverin vitro jusqu'à 24 heures d'allogreffes pancréatico-duodénales, en employant uniquement l'hypothermie et l'hyperbarie. Ces blocs pancréatico-duodénaux conservés ont été en suite allograffés chez des chiens pancréatectomisés, en obtenant la survie des animaux durant de longues périodes. Nous venons de pratiquer une allogreffe pancréatico-duodénale chez des malades avec diabète juvénile et insuffisance rénale. Parmi ces sujets, 9 ont reçu en même temps une allogreffe rénale prélevée du cadavre. Chez tous ces patients, sauf un, le pancréas a fonctionné immédiatement. Cette exception est représentée par un sujet qui a reçu une allogreffe pancréatico-duodénale prélevée du cadavre après avoir subi une ischémie irréversible. Bien que deux patients seulement soient actuellement en vie (maximum depuis onze mois), nous n'avons jamais observé de signes de rejet du pancréas. Dans 7 cas sur 8 la morte était due à complications en rapport avec l'allogreffe rénale de cadavre, tandis que chez un patient seulement l'allogreffe pancréatico-duodénale était la cause du décès. Ce malade est mort sept mois après l'intervention à cause d'une perforation aiguë du duodénum greffé. De ces recherches il résulte évident que l'antigénicité du pancréas est très inférieure à celle du rein et probablement à celle de bien d'autres organes. L'allogreffe pancréatico-duodénale isolée est actuellement projetée pour les diabétiques juvéniles avec néphropathie grave mais non terminale. Si la vasculopathie caractéristique du diabète sera modifiée par une allogreffe de pancréas, cela deviendra alors une procédure de transplantation d'exécution courante.
    Abstract: Resumen Se ha preparado en el ámbito experimental de laboratorio un procedimiento de alotrasplante pancreático-duodenal en perros operados de pancreactomía. Los perros sometidos a trasplante, y tratados después con azatioprina y prednisón para prevenir el rechazo, sobrevivieron durante muchos meses. Al revés de lo que habitualmente se opina, el pancreas no es particularmente sensible a la isquemia total, puesto que ha sido posible conservarin vitro hasta 24 horas un alotrasplante pancreático-duodenal empleando solamente la hipotermia y hiperbaria. Esos bloques pancreático-duodenales conservados, han sido después alotrasplantados en perros operados de pancreactomía consiguiendo la supervivencia de los perros durante largos periodos de tiempo. Hemos efectuado también un alotrasplante pancreático-duodenal en diez pacientes con diabetes juvenil e insuficiencia renal. Nueve de esos pacientes recibieron simultaneamente un alotrasplante renal extraido del mismo cadáver. En todos estos pacientes, menos en uno, el pancreas ha funcionado inmediatamente. La mencionada excepción la constituye un paciente que recibió un alotrasplante pancreático-duodenal procedente de un cadáver, después de haber sufrido una isquemia irreversible. Aunque solamente dos de los mencionados pacientes sigan con vida, todo lo más a los once meses, en ningún caso hemos advertido indicios de rechazo del pancreas. En siete casos de cada ocho la muerte se debió a complicaciones relacionadas con el alotrasplante renal de cadáver y sólo en uno la causa de la muerte se debió al alotrasplante pancreático-duodenal por una perforación aguda del duodeno trasplantado. De estas investigaciones se deduce con evidencia que la antigenicidad del páncreas es mucho menor que la del riñón y probablemente menor también que la de otros órganos. En la actualidad se proyecta el solo alotrasplante pancreático-duodenal para diabéticos juveniles, con nefropatía grave pero no terminal. Si la vasculopatía característica de la diabetes mellitus será modificada por el alotrasplante pancréatico, este último se convertirá en uno de los procedimientos de trasplante de ejecución más común.
    Notes: Riassunto È stato messo a punto in laboratorio un procedimento per l'allotrapianto pancreatico-duodenale nel cane pancreatectomizzato. I cani nei quali sono stati praticati questi trapianti sono sopravvissuti per molti mesi, se trattati con azatioprina e prednisone per prevenire il rigetto. Contrariamente a quanto abitualmente si ritiene, il pancreas non è particolarmente sensibile all'ischemia totale, dato che è stato possibile conservarein vitro fino a 24 ore un allotrapianto pancreatico-duodenale impiegando solamente l'ipotermia e l'iperbaria. Questi blocchi pancreatico-duodenali conservati sono stati poi allotrapiantati in cani pancreatectomizzati, ottenendo la sopravvivenza degli animali per lunghi periodi di tempo. Finora abbiamo effettuato allotrapianti pancreatico-duodenali in dieci pazienti con diabete giovanile ed insufficienza renale. Nove di questi pazienti hanno ricevuto contemporaneamente un allotrapianto renale prelevato dal medesimo cadavere. In tutti questi pazienti, tranne in uno, il pancreas ha funzionato immediatamente. Questa eccezione è rappresentata da un paziente che ricevette un allotrapianto pancreatico-duodenale da cadavere dopo aver subìto una ischemia irreversibile. Sebbene soltanto due pazienti siano attualmente in vita — uno da undici mesi —, in nessun caso abbiamo riscontrato segni di rigetto del pancreas. In sette casi su otto la morte era dovuta a complicazioni legate all'allotrapianto renale di cadavere, mentre in un paziente soltanto l'allotrapianto pancreatico-duodenale era la causa del decesso. Questo paziente morì, sette mesi dopo l'allotrapianto pancreatico-duodenale, per perforazione acuta del duodeno trapiantato. Risulta evidente da queste ricerche che l'antigenicità del pancreas è di gran lunga minore di quella del rene e, probabilmente, anche di altri organi. Il solo allotrapianto pancreatico-duodenale viene ora progettato per pazienti con diabete giovanile e nefropatia grave non in stadio terminale. Se la caratteristica vasculopatia del diabete mellito risulterà modificata per effetto dell'allotrapianto pancreatico, questo diverrà allora uno dei procedimenti di trapianto di più comune esecuzione.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01556827
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