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  • Electronic Resource  (2)
  • 2000-2004  (1)
  • 1990-1994  (1)
  • 1980-1984
  • Column liquid chromatography  (1)
  • Corticobasal ¶degeneration  (1)
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  • Electronic Resource  (2)
Years
  • 2000-2004  (1)
  • 1990-1994  (1)
  • 1980-1984
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  • 1
    Electronic Resource
    Electronic Resource
    Tau-positive neurons in corticobasal degeneration and Alzheimer’s disease – distinction by thiazin red and silver impregnations (2000)
    Springer
    Acta neuropathologica 100 (2000), S. 385-389 
    Details
    ISSN: 1432-0533
    Keywords: Key words Alzheimer’s disease ; Corticobasal ¶degeneration ; Paired helical filaments ; Thiazin red ; Tau
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thiazin red (TR), a fluorochrome that has an affinity to fibrillary structures such as neurofibrillary tangles (NFTs) or senile plaques, was utilized to investigate assembly of tau protein into fibrils in tau-immunopositive neocortical neurons of corticobasal degeneration (CBD) and of Alzheimer’s disease (AD). Double fluorescence with anti-paired helical filament monoclonal antibody (AT8) and TR was followed by either the Gallyas or Bodian silver impregnation method, which enabled a comparison of the staining features by three different methods on the same neuron. NFTs of AD were uniformly stained by TR and Gallyas method. Most of tau-immunopositive neurons of CBD were similarly stained by Gallyas method but barely or only weakly by TR or Bodian method, suggesting that tau in neocortical neurons of CBD is less liable to form fibrillary structures than in those of AD, easily distinguishable by TR staining. Clarifying the process of tau assembly using this fluorochrome will give a clue to understanding mechanisms of tau deposition, which may be different in various neurological disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010000186
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Total chromatographic optimization (TOCO) I. Simultaneous optimization of many variables in liquid chromatography (1990)
    Springer
    Chromatographia 30 (1990), S. 85-90 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Optimization of variables ; Information theory ; Kalman filter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The following chromatographic variables are totally optimized based on the recently developed information theory of optimization: mobile phase composition, column length, flow rate, wavelength, and the amount of internal standard. The optimal internal standard is selected from among six candidates. Two types of optimal conditions (Φ- and ϑ-optimals) are proposed: the Φ-optimal is defined as the most precise analysis (the maximal Φ) while the ϑ-optimal is the most efficient (rapid) analysis (the maximal ϑ). The observation times for the determination of an antipyretics mixture (three components) in liquid chromatography are ca. 50 s for the ϑ-optimal and ca. 8 min for the Φ-optimal. The reliability of the Φ- and ϑ-optimals is verified by experiments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02270454
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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