ISSN:
1612-1112
Keywords:
Column liquid chromatography
;
Optimization of variables
;
Information theory
;
Kalman filter
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary The following chromatographic variables are totally optimized based on the recently developed information theory of optimization: mobile phase composition, column length, flow rate, wavelength, and the amount of internal standard. The optimal internal standard is selected from among six candidates. Two types of optimal conditions (Φ- and ϑ-optimals) are proposed: the Φ-optimal is defined as the most precise analysis (the maximal Φ) while the ϑ-optimal is the most efficient (rapid) analysis (the maximal ϑ). The observation times for the determination of an antipyretics mixture (three components) in liquid chromatography are ca. 50 s for the ϑ-optimal and ca. 8 min for the Φ-optimal. The reliability of the Φ- and ϑ-optimals is verified by experiments.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02270454
