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  • 1
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 79 (2001), S. 3419-3421 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We propose a method to improve the thermal stability of thin CoSi2 layers on polycrystalline silicon substrates. Nitrogen atoms have been implanted at 55 keV to a dose of 5×1015/cm2 through a 70 nm silicide layer in order to locate the implanted peak near the silicide/silicon interface. The large band of cavities created at the interface has extended the thermal stability window by 125 °C with respect to the standard process. The improvement has been related to the silicide grain-boundary pinning due to the increase of the interface free energy contribution. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 81 (2002), S. 55-57 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: N-induced cavity nucleation at the CoSi2/Si interface has been investigated for different doses and its influence on improving the thermal stability of the silicide layer up to 1075 °C has been detailed. The N-implant energy and doses have been chosen in such a way that the projected range (Rp) was near the interface and the underlying polycrystalline silicon substrate was completely amorphized. After a thermal treatment of 975 °C, it has been found that the cavity density depends on the dose, but the cavity size is dose independent. The cavity density should be enough to saturate the silicide grain boundaries but not so high to neglect ripening and coalescence. A density of 2.5×1010 cavities/cm2 has been measured at a nitrogen dose of 7×1015/cm2 corresponding to a partial saturation of the silicide grain boundaries and to the higher stability gain (150 °C). © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary.  Patients with haemophilia show high prevalence of hepatitis C infection but low rate of progressive liver disease when they are not co-infected with HIV. The balance between host immune system and hepatitis C virus (HCV) variability seems to play a major role in the evolution of the HCV-related disease. To address this point we have studied, in a group of selected patients with haemophilia, the composition and in some cases the evolution, of the highest variable envelope gene within the hypervariable region 1 (HVR1) of the HCV, which is the region more directly exposed to the host immune response. Five of 12 patients show a very high homogeneity of the HVR1 and four of those had severe progressive liver disease. These results seem to confirm the major role of the immunity in driving the variability of the HCV rather than the high degree of different HCV strains to which haemophiliacs have been in touch with, during their long-term replacement therapy. Our results seem in keeping with other studies on different type of patients, where a low degree of quasispecies variability has been demonstrated in relationship with the progression and the severity of their liver disease.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 20 (1994), S. 219-221 
    ISSN: 1432-1238
    Keywords: Buflomedil ; Acute intoxication ; Partial anticholinergic syndrome ; Neuroleptic action ; Mydriasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 15-year-old girl was admitted to ICU in a comatose state. She presented with mydriasis, areflexia, hypoxemia and seizures. She was immediately intubated and connected to a ventilator. The seizures were reversed with intravenous diazepam. CT scan was negative. EEG showed a diffuse fast activity and theta waves with spikes in the anterior and temporal regions, bilaterally. The gastric lavage was suggestive of drug ingestion. The patient completely recovered after 6 h of mechanical ventilation and supportive management. Mydriasis was still present after the resolution of neurological symptoms. The girl told us she had ingested 10 tablets (3 g–55 mg/kg) of Loftyl (buflomedil) for suicidal intention. The buflomedil concentrations at 2–3 h from ingestion were 24.8 mg/l in the blood, 324.4 mg/l in the urine and 6.9 mg/l in the gastric content. The p-desmethyl metabolite was also identified in the urine. Buflomedil is a rheological agent largely used as a vasodilator in some European countries. Some recent reports have emphasized the risk of acute intoxication with this drug. Relatively low doses (50–60 mg/kg) have been associated with an important neurological toxicity and a high mortality. We suggest that the clinical picture we observed might be related to a neuroleptic-type action of buflomedil. We bring to attention the risk of a large, uncontrolled diffusion of a drug capable to cause serious consequences at relatively low doses.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0931-1890
    Keywords: Key words Electron paramagnetic resonance spectroscopy ; Photosynthesis ; Ageing ; Pinus nigra ; Biosensors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract  Differently aged needles from a Pinus nigra Arnold tree growing in a typical urban area have been examined by means of electron paramagnetic resonance (EPR) spectroscopy, and the variation of the observed six-line Mn (II) signal was monitored for 1 year. An inverse trend has been established between the photosynthetic efficiency of the plant and the measured content of Mn (II). The possibility of using EPR spectroscopy in studying ageing and in assessing stress situations in plants is considered.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1238
    Keywords: Unilateral lung atelectasis ; Double lumen tracheostomy tube ; Differential lung ventilation ; Monitoring selective respiratory mechanics ; Compliance ; Intrinsic PEEP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two patients with refractory hypoxemia due to unilateral lung atelectasis were treated with differential lung ventilation (DLV) through a Robertshaw-type, double-lumen tracheostomy tube. DLV was applied using two non-synchronized ventilators and maintained for 6 and 3 days, respectively. Ventilator settings were chosen in accord to the clinical, laboratory and chest X-rays results. Particularly, tidal volume and PEEP were set to avoid excessively high alveolar pressure and to obtain the highest possible value of compliance. We investigated the mechanical properties of the two lungs separately by measuring airway pressure and compliance of each lung before the beginning of DLV and at 0, 5, 24, and 48 h after. Initially we observed in both patients very low values of compliance (7–9 cm H2O/I) and a significant level of PEEPi (12–8 cm H2O) of the diseased lung, whereas PEEPi in the healthy lung was negligible. The clinical improvement was assessed by sequential chest X-rays and by significant improvement of arterial blood gas and PaO2/FiO2 ratios and was associated with a progressive increase of compliance (24–22 cm H2O/I) and by a fall of PEEPi levels (5–4 cm H2O) of the diseased lung. We also observed an improvement of S $$\bar v$$ O2, O2AVI, PVRI and $$\dot Q$$ va/ $$\dot Q$$ t values (Case 1). The tracheostomy tube used to apply DLV was very reliable, allowing easy nursing care and selective bronchial aspirations. We conclude that DLV is a very useful technique in unilateral lung pathology, and it can be a life saving procedure in selected patients, by supplying volume and PEEP more efficiently to the affected lung.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1084
    Keywords: Chemoembolisation ; Embolisation, hepatic artery ; Hepatocellular carcinoma ; Iodised oil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate the effectiveness of transcatheter arterial embolisation (TAE) as a treatment of hepatocellular carcinoma (HCC) complicating cirrhosis, the survival of 27 untreated patients and 57 TAE-treated patients was compared. Clinical features, laboratory findings and tumour stage were comparable in the two groups of patients. TAE was undertaken with epirubicin, iodised oil and gelatine esponge. Cumulative survival rates at 6, 12, 24 and 36 months were 0.59, 0.47, 0.17 and 0.08 in the untreated group, and 0.87, 0.75, 0.40 and 0.19 in the TAE-treated group (P = 0.01). Patients with Child's grade B cirrhosis and patients with tumour smaller than 25% of the liver volume responded better to TAE. Twenty-four untreated patients and 25 TAE-treated patients died during the follow-up. The complication rate and mortality rate of TAE were 28% and 1.7% respectively. TAE prolongs the survival of patients with HCC complicating cirrhosis; prognosis depends on tumour stage and the degree of hepatic function impairment.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-2277
    Keywords: Key words Transplantation ; Complications ; PTLD
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the period 1973–1998, among 2 139 allograft recipients treated with standard immunosuppression, posttransplant lymphoproliferative disorders (PTLD) developed in 19 patients (0.9 %): one plasmacytic hyperplasia, two polymorphic PTLD, one myeloma, and 15 lymphomas. PTLD developed 1 year after transplantation (tx) in 14 patients. Five patients were diagnosed at autopsy, 2 were lost to follow up, 3 died before therapy could be instituted, and 1 patient has just started chemotherapy. Of the 8 evaluable patients, 2 received acyclovir and are alive in complete remission (CR) and 6 received chemotherapy ± surgery. Of these 6, 4 died of lymphoma and/or infection, 1 died of unrelated causes in CR, and 1 is alive in CR. PTLD is a severe complication of tx, usually running an aggressive course which may preclude prompt diagnosis and treatment. Nevertheless, therapy is feasible and must be tailored on the histologic subtype. Seventy-four percent of patients were diagnosed with late-onset PTLD stressing the need for long-term follow up.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-2277
    Keywords: Neurotoxicity, liver transplantation, cyclosporin ; Liver transplantation, neurotoxicity, cyclosporin ; Cyclosporin, neurotoxicity, liver transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Neurological complications of cyclosporin (CyA) therapy are frequent, usually occurring within the 1st month after transplantation. Though leukoencephalopathy is one of them, it is rarely documented. Here we report the case of an anti-HCV-positive patient with cirrhosis who underwent liver transplantation and developed cyclosporin-induced leukoencephalopathy. The presenting symptoms were dysarthria, difficulty walking, and dysphagia. They were first noted 6 months after transplantation in association with an episode of recurrent HCV acute hepatitis. White matter abnormalities were evident on computed tomography (CT) scanning and magnetic resonance (MR) imaging. This condition improved to some degree after cyclosporin withdrawal. To our knowledge this is the second reported case of CyA neurotoxicity occurring late after liver transplantation. Moreover, the association with acute hepatitis suggests the possibility of graft dysfunction as a contributing and triggering factor.
    Type of Medium: Electronic Resource
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