Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Electronic Resource  (6)
  • 2000-2004  (1)
  • 1985-1989  (5)
Source
Material
  • Electronic Resource  (6)
Years
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    The removal of strontium from the mouse by chelating agents (1989)
    Springer
    Archives of environmental contamination and toxicology 18 (1989), S. 612-616 
    Details
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract The effects of the chelating agents monosodium glutamate, Tiron, tartaric acid, ascorbic acid, 1,4,7,10,13,16-hexaoxacyclooctadecane (18-crown-6), 2,3-dimercaptosuccinic acid (DMSA), succinic acid, malic acid, ethylendiaminetetraacetic acid (EDTA), ethylenglycol-bis-(β-amino-ethylether)-N,N′ tetraacetic acid (EGTA), cyclohexanediaminetetraacetic acid (CDTA) and diethylentriaminepentaacetic acid (DTPA) on the distribution and excretion of intraperitoneally injected strontium were investigated in male Swiss mice. Strontium nitrate was given at a dose equal to 3.78 mmol/kg and ten minutes after, chelators were administered intraperitoneally at doses approximately equal to one-fourth of their respective LD50 values. DTPA, followed by CDTA, EDTA and tartaric acid, was consistently the most effective in increasing the urinary excretion of strontium. Only ascorbic acid increased significantly the fecal excretion of strontium. CDTA, DTPA and ascorbic acid were also the most effective chelators in reducing the concentration of strontium found in various tissues. CDTA, DTPA and tartaric acid are the most effective agents of those tested in the removal of strontium after a single administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01055029
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Control of some aspects of cis-platinum nephrotoxicity (1986)
    Springer
    Archives of toxicology 59 (1986), S. 167-171 
    Details
    ISSN: 1432-0738
    Keywords: Cis-platinum ; Walker 256 carcinoma ; Nephrotoxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The elevations of blood urea nitrogen and serum creatinine caused by cis-platinum in rats can be prevented by a combination of procedures centered around the administration of sodium N-methyl-N-dithiocarboxyglucamine (NaG), before and very soon after the cis-platinum is administered in hypertonic (4.5%) saline. Elevations inblood urea nitrogen and serum creatinine levels subsequent to such treatment are largely eliminated. These same procedures appear to have no effect on the anti-tumor action of the cis-platinum, as measured by tumor size and mass and by survival times, in female Sprague-Dawley rats inoculated with the Walker 256 carcinoma. The degree of myelosuppression, as measured by the white blood cell count is also slightly reduced. White blood cell counts returned to normal values more rapidly in animals treated with NaG than in those treated with cis-platinum alone. An examination of the dose-response curve for the suppression of cis-platinum nephrotoxicity by NaG shows that this can be achieved with mole ratios of NaG: cis-platinum as low as 1∶1 given after appropriate pretreatment. A preliminary structure-activity study on the suppression of cis-platinum induced elevations in blood urea nitrogen and serum creatinine by four closely related dithiocarbamates shows that this can also be achieved effectively by several dithiocarbamates in which the nitrogen atom bears polar substituents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00316327
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Relative efficacy of chelating agents as antidotes for acute gallium nitrate intoxication (1987)
    Springer
    Archives of toxicology 59 (1987), S. 382-383 
    Details
    ISSN: 1432-0738
    Keywords: Gallium nitrate ; Deferoxamine mesylate ; Citric acid ; Succinic acid ; Malic acid ; Oxalic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twelve chelating agents were administered to mice by IP injection to compare their relative effectiveness in preventing death after a single IP injection of gallium nitrate. Na2Ca-ethylenediaminetetraacetate (EDTA), Na3Ca-diethylenetriaminepentaacetate (DTPA), dimercaptosuccinic acid (DMSA), 4,5-dihydroxy-1,3-benzenedisulfonic acid (Tiron), sodium diethyldithiocarbamate (DDC), L-cysteine and sodium salicylate were not effective for acute gallium nitrate intoxication. The therapeutic indices of the effective chelators were: 25.4 (deferoxamine mesylate), 35.7 (citric acid), 42.3 (succinic acid), 52.2 (malic acid) and 111.1 (oxalic acid).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00295095
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Antidotes for zinc intoxication in mice (1988)
    Springer
    Archives of toxicology 61 (1988), S. 321-323 
    Details
    ISSN: 1432-0738
    Keywords: Zinc ; Mice ; Intraperitoneal administration ; Zinc antidotes ; EDTA ; DTPA ; CDTA ; d-penicilamine ; DMPS ; DMSA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sixteen chelating agents were examined to determine their relative efficacy as antidotes in acute zinc acetate intoxication in mice after i.p. administration. For a i. p. dose of 0.49 mmol/kg (LD50) of zinc acetate, the i. p. administration of chelating agents at a 2∶1 and 5∶1 mole ratio resulted in a significant antidotal action for EDTA, DTPA, CDTA, d-penicillamine (d-PA), DMPS and DMSA. EGTA, l-cysteine, triethylentetraamine (TTHA), N-acetylcysteine (NAC), 4,5-dihydroxi-1,3-benzenedisulfonic acid (Tiron), sodium salicylate, glutathione, sodium diethyldithiocarbamate (DDC), 6-mercaptopurine and N-acetyl-d, l-penicillamine (NAPA) were not effective for acute zinc acetate poisoning. The therapeutic indices and therapeutic effectiveness of the most effective chelators were, respectively: EDTA (5.0, 7.0), DTPA (7.3, 13.7), CDTA (8.6, 6.3), d-PA (4.6, 1.9), DMPS (1.3, 1.0), DMSA (3.2, 5.4). DTPA, CDTA, and EDTA appear to be the most effective agents of those tested in offsetting acute zinc intoxication in mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00364857
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Comparison of the effectiveness of several chelators after single administration on the toxicity, excretion and distribution of cobalt (1986)
    Springer
    Archives of toxicology 58 (1986), S. 278-281 
    Details
    ISSN: 1432-0738
    Keywords: Cobalt ; Intraperitoneal administration ; Mice ; EDTA ; DTPA ; DMSA ; N-Acetylcysteine ; Glutathione ; L-Cysteine ; D,L-penicillamine ; BAL
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of the chelating agents Na2Ca-ethylendiaminetetraacetate (EDTA), Na3Ca-diethylentriaminepentaacetate (DTPA), L-cysteine, 2,3-dimercaptosuccinic acid (DMSA), N-acetyl-L-cysteine (NAC), glutathione, D,L-penicillamine (D,L-PEN) and 2,3-dimercaptopropanol (BAL) on the toxicity, distribution and excretion of intraperitoneally injected cobalt were studied in male Swiss mice. To determine the effect of the various chelators on the toxicity of cobalt, various doses of CoCl2 (0.60–1.80 mmol/kg) were given, followed immediately by the IP administration of the chelator (at a dose equal to one-fourth of their respective LD50). EDTA and DTPA were the most effective. EDTA, DTPA and L-cysteine, NAC and glutathione were also the most effective in increasing the urinary excretion of cobalt and reducing the concentration of the metal in various tissues. EDTA appears to be the most effective agent of those tested in the prevention of acute cobalt intoxication.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00297121
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Vanadium and diabetes. What about vanadium toxicity? (2000)
    Springer
    Molecular and cellular biochemistry 203 (2000), S. 185-187 
    Details
    ISSN: 1573-4919
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007067011338
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...