Library

X
You have 0 saved results.
Mark results and click the "Add To Watchlist" link in order to add them to this list.
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Electronic Resource  (3)
  • 2000-2004  (1)
  • 1965-1969  (2)
Source
Material
  • Electronic Resource  (3)
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    CD80(B7.1) and CD86(B7.2) Do not Have Distinct Roles in Setting the Th1/Th2 Balance in Autoimmunity in Rats (2001)
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 54 (2001), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Some data suggest that the interaction between CD28 and CD80 (B7.1) stimulates Th1-responses and that CD28 and CD86 (B7.2) stimulates Th2-responses, however this is controversial. We addressed this issue by using mercuric chloride (HgCl2)-induced autoimmunity in Brown Norway (BN) rats as a highly polarized Th2 model and experimental autoimmune encephalomyelitis (EAE) in Lewis rats as a highly polarized Th1 model. Monoclonal antibodies (MoAbs) to CD80 and CD86, given singly, had little effect in either model, however when given together they almost completely suppressed the HgCl2-induced autoimmunity: the peak immunoglobulin (Ig)E concentration was 3.25 µg/ml in treated animals versus 2770 µg/ml in controls (P 〈 0.0001); caecal vasculitis was suppressed with a median vasculitis score of 0 in treated animals versus 6 in controls (P 〈 0.0001); and new germinal centre formation was significantly suppressed. A combination of the antibodies also markedly reduced the severity of clinical EAE; from a median aggregate clinical score of 9 to 3 (P = 0.02) and delayed the onset from a median of 12.5 days to 16 days after immunization (P = 0.006). We have demonstrated profound suppression of both Th1 and Th2-driven autoimmunity in rats by a combination of anti-CD80 and CD86, but have been unable to demonstrate any clear differential effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.2001.00998.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Turbidity Changes in a Myelin Fraction induced by ATP and ADP (1969)
    [s.l.] : Nature Publishing Group
    Nature 221 (1969), S. 775-776 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] "Water shock" is an essential step in the preparation of purified myelin1'2. The low enzymatic activity of such fractions and, in particular, the absence of ATPase could be a consequence of the removal of contaminants with high enzymatic activity. On the other hand, many enzymatic reactions which ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/221775a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Subcellular Preparation of Peripheral Nerve Myelin (1968)
    [s.l.] : Nature Publishing Group
    Nature 220 (1968), S. 171-173 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In discussion at a symposium at Liblice2, Professor E. Gutmann and Dr H. Koenig suggested that we should try to prepare a residue of myelin from dorsal spinal roots by plucking out their axons with forceps after treating these peripheral nerves with a glycine-diethylamine buffer3. This suggestion ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/220171a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...