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  • Electronic Resource  (52)
  • 2000-2004  (45)
  • 1960-1964  (7)
  • 11
    Electronic Resource
    Electronic Resource
    THE INHIBITION OF MONOAMINE OXIDASE BY BENZYL AND PHENETHYLGUANIDINES RELATED TO BRETYLIUM AND GUANETHIDINE (1963)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 107 (1963), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1963.tb13337.x
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  • 12
    Electronic Resource
    Electronic Resource
    A multiconfiguration self-consistent field/molecular dynamics study of the (n→π*)1 transition of carbonyl compounds in liquid water (2000)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 113 (2000), S. 6308-6315 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: A model is presented for the electrostatic component of solvatochromic shifts in vertical electronic excitation energies. The model, which makes use of the mean-field approximation, combines quantum mechanics (QM) in the description of the solute molecule and molecular mechanics (MM) in the description of the solvent. The method is implemented at the multiconfigurational self-consistent field level. We present illustrative applications to the (n→π*)1 transitions of formaldehyde, acetaldehyde, and acetone in liquid water. The solvent shifts obtained compare well with other ab initio QM/MM calculations and when the electron correlation components are included with the experimental solvent shift, but differ from the results obtained with semiempirical QM/MM and continuum models. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1308283
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  • 13
    Electronic Resource
    Electronic Resource
    A theoretical study of liquid alcohols using averaged solvent electrostatic potentials obtained from molecular dynamics simulations: Methanol, ethanol and propanol (2002)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 116 (2002), S. 1613-1620 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We applied a quantum mechanics/molecular mechanics method that makes use of the mean field approximation to study the polarization of several alcohols in the liquid phase. The method is based on the calculation of the averaged solvent electrostatic potential from molecular dynamics data. Because of the reduced number of quantum calculations that our approximation involves, it permits the use of flexible basis sets, the consideration of the electron correlation and the solvent and solute polarization. We found that the molecules studied undergo strong polarization when they pass from the gas to the liquid phase. From this point of view, the polarization methanol displays a behavior lightly different from ethanol and propanol. The vaporization energies are very well reproduced especially when the correlation energy is included. The differences with the experimental values are less than 3% in the three systems studied. Finally, we consider the effect on the thermodynamics and the structure of the solution of the choice of the Lennard-Jones parameters. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1430253
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  • 14
    Electronic Resource
    Electronic Resource
    Calcium-Dependent Effects of Melatonin Inhibition of Glutamatergic Response in Rat Striatum (2001)
    Oxford, UK : Blackwell Science, Ltd
    Journal of neuroendocrinology 13 (2001), S. 0 
    Details
    ISSN: 1365-2826
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effects of melatonin, amlodipine, diltiazem (l-type Ca2+ channel blockers) and ω-conotoxin (N-type Ca2+ channel blocker) on the glutamate-dependent excitatory response of striatal neurones to sensory-motor cortex stimulation was studied in a total of 111 neurones. Iontophoresis of melatonin produced a significant attenuation of the excitatory response in 85.2% of the neurones with a latency period of 2 min. Iontophoresis of either l- or N-type Ca2+ channel blocker also produced a significant attenuation of the excitatory response in more than 50% of the recorded neurones without significant latency. The simultaneous iontophoresis of melatonin + amlodipine or melatonin + diltiazem did not increase the attenuation produced by melatonin alone. However, the attenuation of the excitatory response was significantly higher after ejecting melatonin + ω-conotoxin than after ejecting melatonin alone. The melatonin–Ca2+ relationship was further supported by iontophoresis of the Ca2+ ionophore A-23187, which suppressed the inhibitory effect of either melatonin or Ca2+ antagonists. In addition, in synaptosomes prepared from rat striatum, melatonin produced a decrease in the Ca2+ influx measured by Fura-2AM fluorescence. Binding experiments with [3H]MK-801 in membrane preparations from rat striatum showed that melatonin did not compete with the MK-801 binding sites themselves although, in the presence of Mg2+, melatonin increased the affinity of MK-801. The results suggest that decreased Ca2+ influx is involved in the inhibitory effects of melatonin on the glutamatergic activity of rat striatum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2826.2001.00656.x
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  • 15
    Electronic Resource
    Electronic Resource
    Physiological Concentrations of Melatonin and Corticosterone in Stress and their Relationship with Phagocytic Activity (2002)
    Oxford, UK : Blackwell Science, Ltd
    Journal of neuroendocrinology 14 (2002), S. 0 
    Details
    ISSN: 1365-2826
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of the present work was to investigate the possible connection between melatonin, corticosterone and the nonspecific immune response under both basal and stressed conditions. The concentrations used in the present study were as determined in an earlier work, and corresponded to the minimum and maximum concentrations of the hormones melatonin and corticosterone over one circadian cycle in mice subjected to stress and in a basal group of mice. The concentrations were 15 pg/ml and 90 pg/ml of melatonin and 50 ng/ml and 200 ng/ml of corticosterone for incubations of the basal group macrophages, and 15 pg/ml and 70 pg/ml and 200 ng/ml and 500 ng/ml of melatonin and corticosterone, respectively, for incubations of macrophages from the group of stressed mice. The results indicate that corticosterone stimulates antigen ingestion at all physiological doses tested in the macrophages from the unstressed mice. The greatest phagocytic stimulation was obtained in macrophages from mice in a basal situation, and which had been incubated with the diurnal concentrations of the two hormones (maximum corticosterone 200 ng/ml; minimum melatonin 15 pg/ml). When the macrophages were from stressed mice, neither corticosterone nor melatonin led to any change in their phagocytic activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2826.2002.00823.x
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  • 16
    Electronic Resource
    Electronic Resource
    Neurogenesis in explants from the walls of the lateral ventricle of adult bovine brain: role of endogenous IGF-1 as a survival factor (2003)
    Oxford, UK : Blackwell Science, Ltd
    European journal of neuroscience 17 (2003), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Previous studies have shown the existence of proliferating cells in explants from bovine (Bos Taurus) lateral ventricle walls that were maintained for several days in vitro in the absence of serum and growth factors. In this study we have characterized the nature of new cells and have assessed whether the insulin-like growth factor-1 (IGF-1) receptor regulates their survival and/or proliferation. The explants were composed of the ependymal layer and attached subependymal cells. Ependymal cells in culture were labelled with glial markers (S-100, vimentin, GFAP, BLBP, 3A7 and 3CB2) and did not incorporate bromodeoxiuridine when this molecule was added to the culture media. Most subependymal cells were immunoreactive for βIII-tubulin, a neuronal marker, and did incorporate bromodeoxiuridine. Subependymal neurons displayed immunoreactivity for IGF-1 and its receptor and expressed IGF-1 mRNA, indicating that IGF-1 is produced in the explants and may act on new neurons. Addition to the culture media of an IGF-1 receptor antagonist, the peptide JB1, did not affect the incorporation of bromodeoxiuridine to proliferating subependymal cells. However, JB1 significantly increased the number of TUNEL positive cells in the subependymal zone, suggesting that IGF-1 receptor is involved in the survival of subependymal neurons. In conclusion, these findings indicate that neurogenesis is maintained in explants from the lateral cerebral ventricle of adult bovine brains and that IGF-1 is locally produced in the explants and may regulate the survival of the proliferating neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.2003.02432.x
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  • 17
    Electronic Resource
    Electronic Resource
    Respiratory syncytial virus augments production of fibroblast growth factor basic in vitro: Implications for a possible mechanism of prolonged wheezing after infection (2003)
    Oxford, UK : Munksgaard International Publishers
    Pediatric allergy and immunology 14 (2003), S. 0 
    Details
    ISSN: 1399-3038
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Respiratory syncytial virus (RSV) has been linked to the development of clinical asthma. Cellular mechanisms of this observation are not yet clearly elucidated. In chronic asthma, production of growth factors and remodeling are associated with prolonged wheezing. It was hypothesized that cells infected with RSV may produce excessive levels of fibroblast growth factor basic (FGFb), and epidermal growth factor (EGF). Airway epithelial cells were incubated with either: (i) virus, (ii) inactivated virus, or (iii) media only. The levels of FGFb and EGF were measured in the cellular supernatant fluid. The study demonstrated that by 24 h after RSV inoculation, or exposure to RSV-killed virus, cells are stimulated to produce significantly more FGFb, compared with non-infected/non-exposed control cells. FGFb is an important factor in remodeling and fibroblast activation in the airway. Using treatment with actinomycin D and cylcohexamide the effect of inhibiting translation or transcription in the infected cells, on FGFb production was demonstrated. There were no alterations in EGF production detectable. Based on the findings, the mechanism of FGFb secretion after RSV inoculation, appears to be regulated at the levels of both transcription and translation. The increased FGFb release potentially could contribute to fibroblast activation and remodeling in the airway, and thus provide another possible mechanism for prolonged wheezing after infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.0905-6157.2003.00090.x
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  • 18
    Electronic Resource
    Electronic Resource
    Estrogenic Activity and Volume Fraction of Waste Water Origin in Monitoring Wells Along the Santa Cruz River, Arizona (2004)
    Oxford, UK : Blackwell Publishing Ltd
    Ground water monitoring & remediation 24 (2004), S. 0 
    Details
    ISSN: 1745-6592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: The fate of estrogenic activity in waste water effluent was examined during surface transport and incidental recharge along the Santa Cruz River in Pima County, Arizona. Based on measurement of boron isotopes, the fractional contribution of reclaimed water in surface waters and ground water wells proximate to the river was determined for a contemporary sample set. Estrogenic activity decreased by −60% over the 25 mi length of the river below effluent discharge points in Tucson. In ground water samples obtained from monitoring wells that are proximate to the Santa Cruz River, both dissolved organic carbon (p= 0.0003) and estrogenic activity (p= 3 × 10−6) were highly correlated to fractional waste water content. Results indicate that proximate ground water quality is sensitive to incidental recharge of reclaimed water in the Santa Cruz River bed. In a few locations, little attenuation of estrogenic activity was apparent during percolation of effluent in the river channel to well withdrawal points.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-6592.2004.tb00716.x
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  • 19
    Electronic Resource
    Electronic Resource
    Effect of herbicide diclofop-methyl on proton extrusion from Lolium multiflorum seedlings differing in resistance and in fungal endophyte (Neotyphodium sp.) infection (2003)
    Oxford, UK : Munksgaard International Publishers
    Physiologia plantarum 119 (2003), S. 0 
    Details
    ISSN: 1399-3054
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Lolium multiflorum (Italian ryegrass), an annual weed invading wheat and barley cropping systems, has evolved resistance to diclofop-methyl (DM) herbicide. Earlier studies on the mode of action of DM in susceptible L. multiflorum and L. rigidum populations have shown that herbicide promotes oxidative stress leading to senescence, a process reversible through the action of auxins. The disruption of cell membrane potential (Em) appears to be correlated with DM phytotoxicity in susceptible populations, suggesting that the continuous H+ extrusion from plasmalemma to extracellular space is inhibited. L. multiflorum usually establishes a symbiotic relationship with fungal endophytes of the Neotyphodium genus. This fungus confers to host plants higher survival at sublethal dosages of DM, probably due to the production of auxinic compounds. Our goal was to characterize DM-resistant and DM-susceptible L. multiflorum populations infected (E+) and non-infected (E−) with endophytes, by studying the capacity of H+ bumping of plasmalemma of intact roots under DM selection. We correlated the effects of DM on H+ disruption with plant survival. DM inhibited acidification markedly more in susceptible than in resistant populations. Continued extrusion of H+ by DM-resistant cell membranes was positively related to plant survival and growth. There was no detectable difference in the capacity of bumping H+ between DM-susceptible E+ and E− seedlings, even though survival was higher in E+ plants. The basis for the differential response in H+ extrusion between resistant and susceptible populations of L. multiflorum is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1399-3054.2003.00188.x
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  • 20
    Electronic Resource
    Electronic Resource
    Impaired type-1 activity and increased NK cells in Gleich's syndrome (2001)
    Copenhagen : Munksgaard International Publishers
    Allergy 56 (2001), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: An altered production of cytokines has been described in Gleich's syndrome. Our aim was to study the cytokine production at the single-cell level in a patient with Gleich's syndrome and to determine whether it changed during a flare episode. Methods: Blood samples were obtained from a 30-year-old woman diagnosed with Gleich's syndrome before and during the subsequent flare of edema of trunk and arms and weight gain. The major lymphoid subsets (CD4+, CD8+, and CD19+) and natural killer (NK) cells were measured by flow cytometry. Cytokine-producing T cells (IL-2, IFN-γ, and IL-4) were quantified in whole blood by intracellular staining with specific monoclonal antibodies and flow cytometry analysis after polyclonal stimulation with phorbol 12-myristate 13-acetate and ionomycin. Results: Increased numbers of immature CD4+CD8+ T cells and NK cells were observed in peripheral blood during the asymptomatic period. The latter population significantly decreased during the flare. Type-1 cells were decreased in both asymptomatic and, more markedly, during the attack with respect to healthy subjects. Conclusions: The decreased type-1 response demonstrated in this patient might be the basis of the hypereosinophilia of Gleich's syndrome. Besides, the NK cells might play a role in the pathogenesis of these inflammatory episodes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.2001.00287.x
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