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  • 1
    Electronic Resource
    Electronic Resource
    Analysis of structural features responsible for the sweetness of the sesquiterpene, hernandulcin (1988)
    Springer
    Cellular and molecular life sciences 44 (1988), S. 447-449 
    Details
    ISSN: 1420-9071
    Keywords: Hernandulcin ; intense sweetener ; synthetic analogues ; taste attributes ; conformational analysis ; structure-activity relationships ; safety assessment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The relationship between sweetness and structure was studied for several analogues of the intensely sweet sesquiterpene, hernandulcin. These derivatives were prepared synthetically, and were subjected to spectroscopic and conformational analysis. With the exception of the parent substance, none of the derivatives tested proved to be sweet. Evidence gathered in this study suggests that hernandulcin binds to its putative receptor through a three-point interaction, involving the C-1 carbonyl and C-1′ hydroxyl groups, and the double bond between C-4′ and C-5′. In the course of a preliminary safety assessment, the 3-desmethyl derivative of hernandulcin was found to be mutagenic towardSalmonella typhimurium strain TM677.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01940543
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  • 2
    Electronic Resource
    Electronic Resource
    Overproduction and rapid purification of the amidase of Streptococcus pneumoniae (1987)
    Springer
    Archives of microbiology 149 (1987), S. 52-56 
    Details
    ISSN: 1432-072X
    Keywords: Streptococcus pneumoniae ; Autolytic enzyme ; Site-directed mutagenesis ; Overproduction ; One-step purification ; Affinity chromatography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Oligonucleotide-directed mutagenesis of a plasmid containing the lytA gene coding for the pneumococcal amidase has allowed the separation of the coding sequence of the gene. This sequence has been placed in plasmid pIN-III(lppP-5)-A3 downstream from both a modified lipoprotein promoter and the lactose promoter to construct the recombinant plasmid pGL100. When Escherichia coli RB 791 (pGL100) was grown in the presence of lactose, the pneumococcal amidase accounted for 7% of the total protein present in this strain after 18 h incubation at 37°C. The overproduced amidase was purified in a single-step procedure using a choline-Sepharose 6B column taking advantage of the fact that this enzyme was the unique protein with affinity for choline present in extracts obtained from E. coli RB791 (pGL100). The development of the above design opens up the possibility of studying the mechanism that regulates the activity of this important autolysin by using physicochemical techniques that require the availability of high amounts of purified amidase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00423136
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  • 3
    Electronic Resource
    Electronic Resource
    Mammary tuberculosis: percutaneous treatment of a mammary tuberculous abscess (2000)
    Springer
    European radiology 10 (2000), S. 531-533 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Tuberculosis – Breast abscess – Computed tomography – Percutaneous management
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. It is currently very rare to find mammary involvement in cases of tuberculosis, in either primary or secondary form. Diagnosis is classically clinical and microbiological, and the basic techniques used in imaging diagnosis are mammography and ultrasound. Computed tomography may define the involvement of the thoracic wall in those cases which present as mammary masses adhering to deep levels, and is also able to evaluate accompanying pulmonary disease, if it is present. Traditionally, treatment has consisted of quadrantectomy and specific antibiotic therapy. We present a case of tuberculous mammary abscess secondary to pulmonary disease, which was treated by percutaneous drainage controlled by CT and specific antibiotic therapy. We revise the diagnosis, differential diagnosis and treatment of mammary tuberculosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050091
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  • 4
    Electronic Resource
    Electronic Resource
    Vapor Absorption Process in Polyethylene Observed by PAL (1992)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 105-110 (Jan. 1992), p. 1597-1600 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/59/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.105-110.1597.pdf
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  • 5
    Electronic Resource
    Electronic Resource
    Graft Polymerization of Methyl Methacrylate onto Polyethylene Films Studied by Positron Annihilation Technique (1992)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 105-110 (Jan. 1992), p. 1641-1644 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/59/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.105-110.1641.pdf
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  • 6
    Electronic Resource
    Electronic Resource
    Precocious puberty and hypothalamic hamartoma. Report on a new case with ultrastructural data (1985)
    Springer
    Acta neurochirurgica 74 (1985), S. 129-133 
    Details
    ISSN: 0942-0940
    Keywords: Precocious puberty ; hypothalamic hamartoma ; glial hamartoma ; ganglioglioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A new case of hypothalamic hamartoma associated with precocious puberty is presented. After reviewing the literature, 23 other cases appeared. The ultrastructural study of the present case revealed common features with other hamartomatous lesions of the central nervous system and with the gangliogliomas. The data suggest that these lesions are morphologically organized in a very similar manner despite their very different growing potential.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01418802
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  • 7
    Electronic Resource
    Electronic Resource
    Vapor Sorption Process in Poly(Ethylene Terephthalate) Studied by PAL (1994)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 175-178 (Nov. 1994), p. 773-776 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/01/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.175-178.773.pdf
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  • 8
    Electronic Resource
    Electronic Resource
    Molecular integrals with Slater basis. II. Fast computational algorithms (1989)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 91 (1989), S. 4213-4222 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: A new algorithm for the calculation of molecular integrals involving STOs is reported. The algorithm enables us to obtain every two-center one-electron integral and the long-range many-center one- and two-electron integrals. The efficient implementation of the algorithm is discussed and its performance is thoroughly tested. The analysis on the stability of the relations employed in the calculation of multipolar moments is included. Futhermore, the computer time required to carry out each step (construction of basic matrices, calculation of multipolar moments, and calculation of two-electron integrals) has also been analyzed. The range of validity of this approach is shown in several molecular integrals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.456800
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  • 9
    Electronic Resource
    Electronic Resource
    Molecular integrals with Slater basis. I. General approach (1989)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 91 (1989), S. 4204-4212 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: A method for the calculation of many-center integrals involving Slater-type orbitals (STOs) is reported. The method is based on the separation of the short- and long-range terms of the potentials generated by charge distributions. The calculation of three-center nuclear attraction integrals and many-center electron repulsion integrals, when the short-range contributions are negligible, is formulated in terms of multipolar moments of charge distributions. Recurrence relations for obtaining the multipolar moments, which enable us to reduce their calculations to the evaluation of some basic integrals, are reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.456799
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  • 10
    Electronic Resource
    Electronic Resource
    Density and binding forces in diatomics (2002)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 116 (2002), S. 1788-1799 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: In a recently reported method, the molecular density is partitioned in minimally deformed atomic contributions, which are expanded in spherical harmonics times radial factors. Here we use this representation to express the electrostatic potential of the molecule, the force on its nuclei, and the conformational variations of energy in terms of some simple integrals of the atomic radial factors. As a first application, we analyze the relationship between the density and the binding forces (and the bonding energy) in the diatomic molecules of the first row atoms. Two types of forces act on each nucleus: the self-pulling exerted by its own cloud and the external force due to the remaining atoms. The self-pulling comes only from the dipole type term of the atomic density. The external force comes from the other clouds and nuclei and is dominated by the effective charges which depend on the outermost region of the charge term. Analyzing the progressive deformations of the atoms when they approach each other, the forces associated with these deformations and their contributions to the energy, one has a detailed description of the chemical bond which is complementary, and in many aspects more appealing, than the conventional ones. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1420403
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