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  • 1
    Electronic Resource
    Electronic Resource
    Historic Landmarks in Clinical Transplantation: Conclusions from the Consensus Conference at the University of California, Los Angeles (2000)
    Springer
    World journal of surgery 24 (2000), S. 834-843 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The transplantation of organs, cells, and tissues has burgeoned during the last quarter century, with the development of multiple new specialty fields. However, the basic principles that made this possible were established over a three-decade period, beginning during World War II and ending in 1974. At the historical consensus conference held at UCLA in March 1999, 11 early workers in the basic science or clinical practice of transplantation (or both) reached agreement on the most significant contributions of this era that ultimately made transplantation the robust clinical discipline it is today. These discoveries and achievements are summarized here in six tables and annotated with references.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002680010134
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  • 2
    Electronic Resource
    Electronic Resource
    Electron, photon, and ion beams from the relativistic interaction of Petawatt laser pulses with solid targets : The 41st annual meeting of the division of plasma physics of the american physical society (2000)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 7 (2000), S. 2076-2082 
    Details
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: In recent Petawatt laser experiments at Lawrence Livermore National Laboratory, several hundred joules of 1 μm laser light in 0.5–5.0-ps pulses with intensities up to 3×1020 W cm−2 were incident on solid targets and produced a strongly relativistic interaction. The energy content, spectra, and angular patterns of the photon, electron, and ion radiations have all been diagnosed in a number of ways, including several novel (to laser physics) nuclear activation techniques. About 40%–50% of the laser energy is converted to broadly beamed hot electrons. Their beam centroid direction varies from shot to shot, but the resulting bremsstrahlung beam has a consistent width. Extraordinarily luminous ion beams (primarily protons) almost precisely normal to the rear of various targets are seen—up to 3×1013 protons with kTion∼several MeV representing ∼6% of the laser energy. Ion energies up to at least 55 MeV are observed. The ions appear to originate from the rear target surfaces. The edge of the ion beam is very sharp, and collimation increases with ion energy. At the highest energies, a narrow feature appears in the ion spectra, and the apparent size of the emitting spot is smaller than the full back surface area. Any ion emission from the front of the targets is much less than from the rear and is not sharply beamed. The hot electrons generate a Debye sheath with electrostatic fields of order MV per micron, which apparently accelerate the ions. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.874030
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  • 3
    Electronic Resource
    Electronic Resource
    Seven-Year Results of Thinning and Burning Restoration Treatments on Old Ponderosa Pines at the Gus Pearson Natural Area (2004)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Restoration ecology 12 (2004), S. 0 
    Details
    ISSN: 1526-100X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract We examined the 7-year effects of three restoration treatments on leaf physiology and insect-resistance characteristics of pre-settlement age ponderosa pines (Pinus ponderosa Dougl. ex Laws.) at the Gus Pearson Natural Area (GPNA) in northern Arizona. Restoration treatments were: (1) thinned in 1993 to approximate pre-Euro-American settlement stand structure, (2) thinned plus prescribed burned in 1994 and 1998, and (3) untreated control. Tree physiological and insect-resistance characteristics were measured in year 2000, 7 years after thinning, using the same procedures as an earlier study performed in 1996. Consistent with the 1996 results, pre-dawn water potential in 2000 was consistently lower in the control than both thinned treatments. Both thinned treatments continued to have increased foliar nitrogen concentration in leaves 7 years after treatment. However lower leaf nitrogen concentration in the thinned and burned compared with the thinned treatment suggests lower nitrogen availability to trees in repeatedly burned plots. Analysis of leaf gas exchange characteristics and carbon isotope content (δ13C) suggests continued stimulation of photosynthesis by both thinning treatments. Differences among treatments in resin volume, a measure of bark beetle resistance, depended on season of measurement. Trees in both thinning treatments continued to have increased leaf toughness, a measure of resistance to insect folivores. Our results show that many beneficial effects of restoration treatments on carbon, water, and nitrogen relations and insect-resistance characteristics of pre-settlement ponderosa pines continue to be expressed 7 years after treatment at the GPNA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1061-2971.2004.00278.x
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  • 4
    Electronic Resource
    Electronic Resource
    Standardized Approach for Developing Probabilistic Exposure Factor Distributions (2004)
    350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Publishing, Inc.
    Risk analysis 24 (2004), S. 0 
    Details
    ISSN: 1539-6924
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: The effectiveness of a probabilistic risk assessment (PRA) depends on the quality and relevance of the output from exposure and risk models, which, in turn, depends on the critical inputs to the assessment. These critical inputs are often in the form of probabilistic exposure factor distributions that are derived for the given risk scenario. Deriving probabilistic distributions for model inputs can be time consuming and subjective. The absence of a standard approach for developing these distributions can result in PRAs that are inconsistent and difficult to review by regulatory agencies. We present an approach that reduces subjectivity in the distribution development process without limiting the flexibility needed to prepare relevant PRAs. The approach requires two steps. First, we analyze data pooled at a population scale to (i) identify the most robust demographic descriptors within the population for a given exposure factor, (ii) partition the data into subsets based on these variables, and (iii) construct archetypal distributions for each subpopulation. Second, we sample from these archetypal distributions according to site- or scenario-specific conditions to simulate exposure factor values and use these values to construct the scenario-specific input distribution. The archetypal distributions developed through Step 1 provide a consistent basis for developing scenario-specific distributions so risk assessors will not have to repeatedly collect and analyze raw data for each new assessment. We demonstrate the approach for two commonly used exposure factors—body weight (BW) and exposure duration (ED)—using data that are representative of the U.S. population. For these factors we provide a first set of subpopulation-based archetypal distributions and demonstrate methods for using these distributions to construct relevant scenario-specific probabilistic exposure factor distributions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0272-4332.2004.00518.x
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  • 5
    Electronic Resource
    Electronic Resource
    A Systematic Uncertainty Analysis of an Evaluative Fate and Exposure Model (2000)
    Boston, USA and Oxford, UK : Blackwell Publishers Inc.
    Risk analysis 20 (2000), S. 0 
    Details
    ISSN: 1539-6924
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Multimedia fate and exposure models are widely used to regulate the release of toxic chemicals, to set cleanup standards for contaminated sites, and to evaluate emissions in life-cycle assessment. CalTOX, one of these models, is used to calculate the potential dose, an outcome that is combined with the toxicity of the chemical to determine the Human Toxicity Potential (HTP), used to aggregate and compare emissions. The comprehensive assessment of the uncertainty in the potential dose calculation in this article serves to provide the information necessary to evaluate the reliability of decisions based on the HTP. A framework for uncertainty analysis in multimedia risk assessment is proposed and evaluated with four types of uncertainty. Parameter uncertainty is assessed through Monte Carlo analysis. The variability in landscape parameters is assessed through a comparison of potential dose calculations for different regions in the United States. Decision rule uncertainty is explored through a comparison of the HTP values under open and closed system boundaries. Model uncertainty is evaluated through two case studies, one using alternative formulations for calculating the plant concentration and the other testing the steady state assumption for wet deposition. This investigation shows that steady state conditions for the removal of chemicals from the atmosphere are not appropriate and result in an underestimate of the potential dose for 25% of the 336 chemicals evaluated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/0272-4332.204043
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  • 6
    Electronic Resource
    Electronic Resource
    Intake Fraction for Multimedia Pollutants: A Tool for Life Cycle Analysis and Comparative Risk Assessment (2002)
    350 Main Street , Malden , MA 02148 , USA , and 108 Cowley Road , Oxford OX4 1JF , UK . : Blackwell Publishing
    Risk analysis 22 (2002), S. 0 
    Details
    ISSN: 1539-6924
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: We employ the intake fraction (iF) as an effective tool for expressing the source-to-intake relationship for pollutant emissions in life cycle analysis (LCA) or comparative risk assessment. Intake fraction is the fraction of chemical mass emitted into the environment that eventually passes into a member of the population through inhalation, ingestion, or dermal exposure. To date, this concept has been primarily applied to pollutants whose primary route of exposure is inhalation. Here we extend the use of iF to multimedia pollutants with multiple exposure pathways. We use a level III multimedia model to calculate iF for TCDD and compare the result to one calculated from measured levels of dioxin toxic equivalents in the environment. We calculate iF for emissions to air and surface water for 308 chemicals. We correlate the primary exposure route with the magnitudes of the octanol-water partition coefficient, Kow, and of the air-water partitioning coefficient (dimensionless Henry constant), Kaw. This results in value ranges of Kow and Kaw where the chemical exposure route can be classified with limited input data requirements as primarily inhalation, primarily ingestion, or multipathway. For the inhalation and ingestion dominant pollutants, we also define empirical relationships based on chemical properties for quantifying the intake fraction. The empirical relationships facilitate rapid evaluation of many chemicals in terms of the intake. By defining a theoretical upper limit for iF in a multimedia environment we find that iF calculations provide insight into the multimedia model algorithms and help identify unusual patterns of exposure and questionable exposure model results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/1539-6924.00260
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  • 7
    Electronic Resource
    Electronic Resource
    Chronic Health Risks from Aggregate Exposures to Ionizing Radiation and Chemicals: Scientific Basis for an Assessment Framework (2001)
    Boston, USA and Oxford, UK : Blackwell Publishers Inc.
    Risk analysis 21 (2001), S. 0 
    Details
    ISSN: 1539-6924
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Very little quantitative analysis is currently available on the cumulative effects of exposure to multiple hazardous agents that have either similar or different mechanisms of action. Over the past several years, efforts have been made to develop the methodologies for risk assessment of chemical mixtures, but mixed exposures to two or more dissimilar agents such as radiation and one or more chemical agents have not yet been addressed in any substantive way. This article reviews the current understanding of the health risks arising from mixed exposures to ionizing radiation and specific chemicals. Specifically discussed is how mixed radiation/chemical exposures, when evaluated in aggregation, were linked to chronic health endpoints such as cancer and intermediate health outcomes such as chromosomal aberrations. Also considered is the extent to which the current practices are consistent with the scientific understanding of the health risks associated with mixed-agent exposures. From this the discussion moves to the research needs for assessing the cumulative health risks from aggregate exposures to ionizing radiation and chemicals. The evaluation indicates that essentially no guidance has been provided for conducting risk assessment for two agents with different mechanisms of action (i.e., energy deposition from ionizing radiation versus DNA interactions with chemicals) but similar biological endpoints (i.e., chromosomal aberrations, mutations, and cancer). The literature review also reveals the problems caused by the absence of both the basic science and an appropriate evaluation framework for the combined effects of mixed-agent exposures. This makes it difficult to determine whether there is truly no interaction or somehow the interaction is masked by the scale of effect observation or inappropriate dose-response assumptions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/0272-4332.t01-1-211085
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  • 8
    Electronic Resource
    Electronic Resource
    Lymphedema of the Arm and Breast in Irradiated Breast Cancer Patients: Risks in an Era of Dramatically Changing Axillary Surgery (2004)
    Oxford, UK : Blackwell Science Inc
    The @breast journal 10 (2004), S. 0 
    Details
    ISSN: 1524-4741
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract:  The purpose of this study was to assess risk for lymphedema of the breast and arm in radiotherapy patients in an era of less extensive axillary surgery. Breast cancer patients treated for cure were reviewed, with a minimum follow-up of 1.5 years from the end of treatment. Clinical, surgical, and radiation-related variables were tested for statistical association with arm and breast lymphedema using regression analyses, t-tests, and chi-squared analyses. Between January 1998 and June 2001, 240 women received radiation for localized breast cancer in our center. The incidence of lymphedema of the ipsilateral breast, arm, and combined (breast and arm) was 9.6%, 7.6%, and 1.8%, respectively, with a median follow-up of 27 months. For breast edema, t-test and multivariate analysis showed body mass index (BMI) to be significant (p = 0.043, p = 0.0038), as was chi-squared and multivariate testing for site of tumor in the breast (p = 0.0043, p = 0.0035). For arm edema, t-test and multivariate analyses showed the number of nodes removed to be significant (p = 0.0040, p = 0.0458); the size of the tumor was also significant by multivariate analyses (p = 0.0027). Tumor size appeared significant because a number of very large cancers failed locally and caused cancer-related obstructive lymphedema. In our center, even modern, limited level 1–2 axillary dissection and tangential irradiation carries the risk of arm lymphedema that would argue in favor of sentinel node biopsy. For breast edema, disruption of draining lymphatics by surgery and radiation with boost to the upper outer quadrant increased risk, especially for the obese. Fortunately both breast and arm edema benefited from manual lymphatic drainage. 
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1075-122X.2004.21411.x
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  • 9
    Electronic Resource
    Electronic Resource
    Professionalism & bioethics (2004)
    Oxford, UK : Blackwell Publishing
    Journal of veterinary emergency and critical care 14 (2004), S. 0 
    Details
    ISSN: 1476-4431
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1534-6935.2004.04019.x
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  • 10
    Electronic Resource
    Electronic Resource
    Strategies for a recessionary economy (2003)
    Oxford, UK : Blackwell Publishing
    Journal of veterinary emergency and critical care 13 (2003), S. 0 
    Details
    ISSN: 1476-4431
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1435-6935.2003.00083.x
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