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  • 1
    Electronic Resource
    Electronic Resource
    Laser effect on vital oral tissues: A preliminary investigation (1972)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 1 (1972), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract. A preliminary investigation into the effects of ruby laser radiation from 4 to 40 joule dosages on the incisor teeth, the dorsal surface of the tongue and the auricular skin was carried out on 20 rats. A unique articulating arm was utilized to direct the energy conveniently to the exposed target. A crater was produced in the labial surface of the incisor, and adjacent to the crater the normal appearing enamel was replaced by a glass-like substance. Severe changes also occupied in the dental pulps, the tongues and the auricular skin. Although the possibility of the clinical application of laser in dentistry is considered to be premature for the time being, data both relevant and interesting enough to encourage further study were obtained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1972.tb01664.x
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  • 2
    Electronic Resource
    Electronic Resource
    Acquired acrodermaties enteropathica during chemotherapy For acute lymphocytic leukaemia in a child with Down syndrome (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 135 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1996.tb03862.x
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  • 3
    Electronic Resource
    Electronic Resource
    Cytotoxicity of endogenous isoquinolines to human dopaminergic neuroblastoma SH-SY5Y cells (1997)
    Springer
    Journal of neural transmission 104 (1997), S. 59-66 
    Details
    ISSN: 1435-1463
    Keywords: Cytotoxicity ; isoquinolines ; N-methylsalsolinol ; 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion ; neuroblastoma SH-SY5Y cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Endogenous isoquinolines with and without catechol structure have been proposed to be neurotoxins specific for dopamine neurons. In this paper they were examined for the cytotoxicity of human dopaminergic neuroblastoma SH-SY5Y cells. The cytotoxicity was quantitatively determined using Alamar Blue assay, by which the reduction-oxidation potency in the living cells can be measured spectrometrically. 1,2-Dimethyl-6,7-dihydroxyisoquinolinium ion [1,2-DMDHIQ+], an oxidation product of a parkinsonism-inducing isoquinoline, 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahyroisoquinoline [N-methyl-(R)salsolinol, NM(R)Sal] was found to be the most potent toxin among isoquinolines examined. In general, catechol isoquinolines were more toxic than isoquinolines without catechol structure. With and without catechol structure, the oxidized isoquinolinium ion having methyl groups at C-1 and N-2 positions proved to be more cytotoxic than the simple isoquinolines. The involvement of 1,2-DMDHIQ+ to the neurotoxicity of NM(R)Sal was suggested and discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01271294
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  • 4
    Electronic Resource
    Electronic Resource
    Characterization of Thermal Degradation of Stainless Steel with Ultrasonic Velocities and Backscattering Noise (1996)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 210-213 (May 1996), p. 283-288 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/01/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.210-213.283.pdf
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  • 5
    Electronic Resource
    Electronic Resource
    A case of juvenile myelomonocytic leukemia with ocular infiltration (1999)
    Springer
    Annals of hematology 78 (1999), S. 568-570 
    Details
    ISSN: 1432-0584
    Keywords: Key words Juvenile myelomonocytic leukemia ; Ocular infiltration ; Bone marrow transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We present a case of juvenile myelomonocytic leukemia (JMML) with ocular infiltration. A 1-month-old boy presented with myeloid precursors in peripheral blood and a white blood cell count  1 10×109/l. His peripheral blood monocyte count was  1 1×109/l, bone marrow blasts were 〈20%, and no Ph chromosome was identified. The boy also presented with hepatosplenomegaly, pallor, fever, and skin rash. We diagnosed this case as JMML, although hemoglobin F was within the normal range and no spontaneous colony growth was observed from peripheral blood mononuclear cells. Neither Epstein-Barr (EB) virus nor cytomegalovirus was detected by PCR in bone marrow aspirate or peripheral blood. The patient had several lesions into which JMML cells might have infiltrated, including skin, liver, spleen, oral cavity, right lung, sigmoid colon, and both eyes. To our knowledge, this is the first reported case of JMML with ocular involvement. Since infiltration of JMML cells into both eyes causes blindness, further consideration of the timing of bone marrow transplantation (BMT) in JMML is necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050561
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  • 6
    Electronic Resource
    Electronic Resource
    Possible mechanism to induce protein kinase C-dependent arterial smooth muscle contraction after subarachnoid haemorrhage (1995)
    Springer
    Acta neurochirurgica 137 (1995), S. 217-225 
    Details
    ISSN: 0942-0940
    Keywords: Subarachnoid haemorrhage ; vasospasm ; 12-hydroxyeicosatetraeonic acid (12-HETE) ; 1,2-diacylglycerol (DAG) ; protein kinase C (PKC)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A possible mechanism for the induction of protein kinase C (PKC)-dependent vascular contraction independent to the increase of intracellular Ca++ was investigated in the pathogenesis of cerebral vasospasm in the double subarachnoid haemorrhage (SAH) model. The level of 1,2-diacylglycerol (DAG), which is an intrinsic PKC activator, significantly increased from days 4 to 7 in the basilar artery after the initial SAH, and the continuous administration of 1,2-bis(nicotinamido)-propane (AVS), a novel free radical scavenger, not only lowered the concentration of lipid peroxides in the CSF but also successfully suppressed the basilar arterial narrowing and the increase of DAG in the basilar arterial wall in the same model. It was suggested that lipid peroxides generated in the subarachnoid clot affect the DAG content of the cerebral artery. Analysis of hydroxy-eicosatetraenoic acids (HETEs) with high performance liquid chromatography (HPLC) revealed the production of relatively large amount of 12-HETE in the subarachnoid clot. To examine the potential effect of exogenous 12-HETE on the DAG content of the cerebral artery, the basilar artery was incubated with 12-HETE in vitro. 12-HETE induced a concentration-dependent slow increase in DAG content in the arterial wall after 6 hours of incubation. Under conditions in which DAG formation was facilitated by the Ca++-ionophore, DAG accumulation in the basilar artery was enhanced in the presence of 12-HETE. It was suggested that 12-HETE generated in the subarachnoid clot, induced DAG accumulation in the arterial wall by inhibition of DAG metabolism, resulting in the induction of prolonged PKC-dependent smooth muscle contraction in the pathogenesis of cerebral vasospasm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02187196
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  • 7
    Electronic Resource
    Electronic Resource
    Neural Activity of the Subthalamic Nucleus in Parkinson's Disease Patients (1998)
    Springer
    Acta neurochirurgica 140 (1998), S. 1287-1291 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Parkinson's disease; subthalamic nucleus; stereotactic surgery.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  The neural activity pattern of the subthalmic nucleus (STN) was investigated in five patients with Parkinson's disease who were scheduled for electrode implantation for chronic stimulation of the STN.  The initial target was placed 8 mm or 10 mm lateral to the midline, 3 mm to 4 mm posterior to the midcommissural point, and 5 mm to 6 mm below the intercommissural (AC-PC) line. The STN was identified by semi-microelectrode recordings with a trajectory moving laterally in 2-mm steps. The amplitudes of multi-unit activities were relatively low at depths from 8 mm to 5 mm above and from 1 mm to 4 mm below the target, while those 4 mm to 0 mm above the target were significantly higher than at the other sites (ANOVA, Fisher's test, p〈0.05), with the highest amplitude at 2 mm above the target (91.0±23.3μv, n=15). In the mediolateral direction, amplitudes were relatively higher in the lateral portion, and amplitudes at 14 mm lateral to the midline were significantly higher than at the other sites (ANOVA, Fisher's test, p〈0.05). The target for chronic electrical stimulation was determined to be at the midpoint of the hyperactive STN, i.e., 12 mm lateral to the midline in three patients and 13 mm lateral in two patients. Movement-related neural activity was observed at 5 sites, i.e., 3 sites responded to passive movement of the contralateral wrist and 2 sites to passive knee and/or ankle movement.  In conclusion, our data show that the lateral part of the STN is hyperactive in PD, and recordings of neural activities contributed greatly to identifying the STN and determining the target for chronic stimulation within it.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050251
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  • 8
    Electronic Resource
    Electronic Resource
    Progress in preclinical and clinical studies for the development of new anticancer drugs in Japan, with emphasis on taxanes (1996)
    Springer
    Cancer chemotherapy and pharmacology 38 (1996), S. S11 
    Details
    ISSN: 1432-0843
    Keywords: Key words Taxane ; Anticancer drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800051030
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  • 9
    Electronic Resource
    Electronic Resource
    Spontaneous resolution of symptoms in an infant with a congenital dural caroticocavernous fistula (1995)
    Springer
    Neuroradiology 37 (1995), S. 247-249 
    Details
    ISSN: 1432-1920
    Keywords: Spontaneous caroticocavernous fistula ; Congenital arteriovenous fistula ; Dural shunt ; Infancy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a 5-week-old boy with a congenital dural caroticocavernous fistula (CCF). He had gradually progressive proptosis, dilated conjunctival veins, chemosis, abducens nerve palsy and an objective bruit. Angiography of the right common carotid artery revealed fistulous communication in the cavernous sinus (CS) region. The CS was fed by the middle meningeal artery and drained through the superior ophthalmic vein and the superior petrosal vein. The child's symptoms and signs disappeared within a few weeks and did not recur over 11 months. At that time, however, angiography still showed a small communication between the right external carotid artery and the CS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01578267
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  • 10
    Electronic Resource
    Electronic Resource
    Magnetic resonance angiography in patients with acute stroke treated by local thrombolysis (1998)
    Springer
    Neuroradiology 40 (1998), S. 536-540 
    Details
    ISSN: 1432-1920
    Keywords: Key words Magnetic resonance angiography ; Cerebral infarction ; acute ; Thrombolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although magnetic resonance angiography (MRA) is accepted for showing chronic intracranial stenotic or occlusive lesions, the method has not been practically examined in patients with acute cerebral ischaemia. We carried out three-dimensional time-of-flight MRA in six patients with acute ischaemia treated by local thrombolysis, and compared the findings with those of digital subtraction angiography (DSA). In all patients, MRA before thrombolysis clearly demonstrated the occluded arteries, which corresponded precisely to those shown by DSA. In four patients with complete recanalisation of the occluded vessels after thrombolysis, the recanalisation could be demonstrated by postoperative MRA. In one patient with reocclusion of the recanalised artery, repeat MRA also demonstrated the reocclusion, confirmed by DSA. These results suggest that MRA may be helpful for noninvasive investigation before and after thrombolysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050642
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