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  • Digitale Medien  (3)
  • 1995-1999  (3)
  • Human skin  (1)
  • Key words Amyotrophic lateral sclerosis  (1)
  • Magnetic resonance imaging  (1)
  • EC; endothelial cells
  • RIA; radioimmunoasay
  • TFA; trifluoroacetic acid
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Materialart
  • Digitale Medien  (3)
Erscheinungszeitraum
Jahr
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  • 1
    Digitale Medien
    Digitale Medien
    A new approach to analysis of human sweating (1996)
    Springer
    Cellular and molecular life sciences 52 (1996), S. 131-135 
    Details
    ISSN: 1420-9071
    Schlagwort(e): Human skin ; heterologous transplant ; immuno-deficient mouse ; eccrine seating ; pilocarpine ; adrenaline ; atropine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract In human skin transplanted to the back of 3 strains of immuno-deficient mice the functin of the eccrine sweat glands of the human transplant was tested by topical intradermal application of pilocarine, adrenaline and atropine+pilocarpine. Sweat responses were observed in pre-selected fields of observation by means of video macroscope. The iodine strarch reaction served as an indicator for the appearance of seat sport and permitted the evaluation of areas wetted by sweat in the field of observation. Among 9 animals tested, the hybrids between the CB-17-scid mouse and the BALB/cA-nu mouse (BALB/cA-nu,scid) seemed to exhibit the most consistent seweating response to local pharmacological stimulation. According to histological examination, eccrine sweat glands were preserved in human skin trasplanted into the back skin of the BALB/cA-nu,scid mouse strain. the heterologous, human skin graft provides a novel model permitting, independent of the normal sweat gland innervation, the analysis of moecular receptors of sweat gland cells by which the actions of natural transmitters and pharmacological agents are transduced.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01923357
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  • 2
    Digitale Medien
    Digitale Medien
    Sporadic amyotrophic lateral sclerosis with multiple system degeneration: a report of an autopsy case without respirator administration (1999)
    Springer
    Acta neuropathologica 98 (1999), S. 512-515 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Key words Amyotrophic lateral sclerosis ; Dentate ; nucleus ; Multiple system degeneration ; Respirator ; Substantia nigra
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract This report concerns an autopsy case of amyotrophic lateral sclerosis (ALS) with unusual clinical and neuropathological findings. The patient was a Japanese man without hereditary burden who was 49 years old at the time of death. His clinical manifestation included dysarthria at age 48, followed by dysphagia, atrophy and fasciculation of the tongue, muscle weakness in the four extremities, tremor, rigidity, increased deep tendon reflexes in the upper and lower extremities, and incoordination of the four extremities. He died of respiratory failure 12 months after the disease onset. No respirator administration was performed throughout the clinical course. The neuropathological examination revealed not only degeneration of upper and lower motor neuron systems, including the presence of Bunina bodies and ubiquitin-immunoreactive neuronal inclusions in the lower motor neurons, but also prominent degeneration of the substantia nigra and dentate nucleus with slight neuronal loss in the locus ceruleus and pontine nucleus. To our knowledge, this is the first reported case of sporadic ALS without dementia and respirator support, showing degeneration of the substantia nigra and dentate nucleus. This report may contribute to the resolution of the question concerning the neuropathological heterogeneity of sporadic ALS with respiratory support.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004010051117
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  • 3
    Digitale Medien
    Digitale Medien
    A new MRI technique for demonstrating the surface of the brain together with the cortical veins (1999)
    Springer
    Neuroradiology 41 (1999), S. 425-427 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Key words Brain ; anatomy ; Magnetic resonance imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We assessed combining of surface-anatomy scanning (SAS) MRI and MR venography (MRV). We obtained SAS images with a half-Fourier single-shot fast spin-echo sequence, then MRV of the identical section with a two-dimensional phase-contrast technique. We then added the two sets of images. The combined images, which were obtained within 10 min, provided information about the surface anatomy and cortical veins. This simple technique is useful for demonstrating brain surface structures, especially in patients from whom one plans to excise a lesion.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002340050776
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