ISSN:
0277-7037
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Physics
Notes:
This article reviews the results of mass spectrometric investigations of the formation mechanism and the energy stabilty of the bioclusters DNA and RNA nucleotide pairs, and nucleoitde base clusters containing certain antitumor medicinal preparations. All of the results discussed were obtained using temperature-dependent field ionization mass spectrometry (TD-FIMS) and well-known and approved desorption mass spectrometry techniques; e.g., fast atom bombardment (FAB) and plasma-desorption mass spectrometry (PDMS).A variety of data are presented on the formation enthalpies of Watson-Crick (Hoogsteen) and other H-bonded base-pairs, nucleobase stacking dimers, base hydrates, and their complementary pairs in vacuum. Analysis of the data permitted a thermodynamic stability sequence of bioclusters under study to be constructed. The nucleobases in rare (enol and imine) tautomer forms are shown to produce H-bonded pairs comparable in energy with the canonical A · T pair.This review summarizes the results of recent investigations into the interactions of DNA, nucleosides, bases, and some amino acids with antitumor preparations such as triethylene thiophosphate amide (thio TEPA), prospydine (Psp), farmorubicin (Far), and doxorubicin (Dox). The specific features of the Dox and Far clusters formation observed in the mass spectra are found to correlate with the antitumor chemotherapeutic activity of these antibiotics. © 1996 John Wiley & Sons, Inc.
Additional Material:
9 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mas.1280140402
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