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  • 1
    Electronic Resource
    Electronic Resource
    In Vitro Stimulation with Glutamic Acid Decarboxylase (GAD65) Leads to an Oligoclonal Response of Peripheral T-Cells in an IDDM Patient (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 42 (1995), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The enzyme glutamic acid decarboxylase (GAD65) is a major autoantigen in insulin-dependent diabetes mellitus (IDDM). To study T-cell reactivity towards GAD, peripheral blood leucocytes from seven patients with IDDM and five control subjects were stimulated in vitro with recombinant GAD. All diabetics studied were heterozygous for diabetes-associated HLA alleles, i. e. HLA-DRB1*03, *04-DQBl*0302, *0201. A single IDDM subject (no. GAD65.05) revealed a strong response against GAD65. After stimulation, his T-cell receptor β (TCRBV) usage was found to be oligoclonal. The sequence analysis of the putative peptide binding region of the T-cell receptor (CDR3 region) of 37 GAD-reactive T-cell clones revealed no common CDR3 motif. The stimulation of GAD-reactive T-cells could be inhibited with anti-class II monoclonal antibodies, indicating a class II restricted T-cell response. In addition, GAD65-responsive T-cells revealed a Thl cytokine response pattern. The author's data suggest that GAD-reactive T-cells of Thl phenotype can be obtained after in vitro stimulation of peripheral blood leucocytes from an HLA-DRBl*03/*04 heterozygous IDDM patient. The lack of a common CDR3 motif suggests the absence of an immunodominant T-cell epitope in that patient, or may indicate receptor repertoire spreading of peripheral T-lymphocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1995.tb03710.x
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  • 2
    Electronic Resource
    Electronic Resource
    Duality in the Quantum Dissipative Villain Model and Application to Mesoscopic Josephson Junction Circuits (1999)
    Springer
    Journal of superconductivity 12 (1999), S. 783-787 
    Details
    ISSN: 1572-9605
    Keywords: Josephson tunneling ; mesoscopic systems ; quantum dissipative systems
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Notes: Abstract We study exact self-duality in the model of a Brownian particle in a washboard (WB) potential which describes a Josephson junction (JJ) coupled to an environment, for arbitrary temperature and arbitrary form of the spectral density of the environment. To this end we introduce the quantum dissipative Villain model (QDVM), which models tunneling of a degree of freedom coupled to a linear quantum environment through an infinite set of states. We derive general exact mappings on various dual discrete representations (one-dimensional Coulomb gases or surface-roughening models) which are exactly self-dual. Then we show how the QDVM maps exactly onto the WB model and use duality relations to calculate the leading terms of the total impedance of a JJ circuit, for general frequency dependence of the spectral density of the environment and arbitrary temperature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007789127384
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  • 3
    Electronic Resource
    Electronic Resource
    Dissipation, decoherence and preparation effects in the spin-boson system (1999)
    Springer
    The European physical journal 10 (1999), S. 719-729 
    Details
    ISSN: 1434-6036
    Keywords: PACS. 05.30.-d Quantum statistical mechanics[:AND:] 05.40.-a Fluctuation phenomena, random processes, noise and Brownian motion - 33.80.Be Level crossing and optical pumping
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: The dynamics of the reduced density matrix of the driven dissipative two-state system is studied for a general diagonal/off-diagonal initial state. We derive exact formal series expressions for the populations and coherences and show that they can be cast into the form of coupled nonconvolutive exact master equations and integral relations. We show that neither the asymptotic distributions, nor the transition temperature between coherent and incoherent motion, nor the dephasing rate and relaxation rate towards the equilibrium state depend on the particular initial state chosen. However, in the underdamped regime, effects of the particular initial preparation, e.g. in an off-diagonal state of the density matrix, strongly affect the transient dynamics. We find that an appropriately tuned external ac-field can slow down decoherence and thus allow preparation effects to persist for longer times than in the absence of driving.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100510050903
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  • 4
    Electronic Resource
    Electronic Resource
    Non-universality of dephasing in quantum transport (1995)
    Springer
    The European physical journal 98 (1995), S. 289-296 
    Details
    ISSN: 1434-6036
    Keywords: 05.40.+j ; 05.60.+w ; 72.10.-d
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We investigate the influence of the environment on coherent quantum transport. While random processes with classical stochastic potentials can be treated in the concept of phase memory, this is not possible for fully quantized system-plus-reservoir models. In the latter case, the decay of coherences is not only depending on the coupled dynamics, but also crucially on the special geometry of the physical system in regard. We introduce a microscopic model with localized environmental modes where the geometry dependence is removed and calculate the coherence length.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01324535
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