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  • Electronic Resource  (3)
  • 1990-1994  (2)
  • 1985-1989  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 17 (1992), S. 0 
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Amorolfine inhibited the in-vitro growth of Trichophyton mentagrophytes to some extent at a low drug concentration of 0·8 ng/ml. Corresponding to the growth inhibition, SEM studies revealed a slight modification of hyphal morphology, i.e. a waving of the hyphal surface. These morphological alterations were more extensive with increases in drug concentration and treatment period: collapsed and distorted hyphae and exfoliation of the surface of T. mentagrophytes occurred at 8 ng/ml and marked deformation and disruption of the hyphal structure at 80 ng/ml of amorolfine. TEM revealed thickening of the cell walls and the accumulation of electron-dense granular structures in both the wall and cytoplasm in thin-sectioned cells pretreated with 8 ng/ml or more of amorolfine, although the nuclear and mitochondrial architecture was not noticeably influenced. Cytoplasmic membranes and other membranous structures of organelles such as nuclei and mitochondria were disrupted or fused, thereby losing their essential physiological activity in hyphal cells pretreated with 80 ng/ml of amorolfine. The ultrastructural study thus supports the observation that morphological changes of T. mentagrophytes caused by amorolfine were associated with its growth-inhibitory and killing activity, which depended on the drug concentration and treatment time.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1572-879X
    Keywords: Plasma-induced chemisorption ; nitrogen chemisorption ; Ru black catalyst ; production of ammonia ; the reactivity of chemisorbed nitrogen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Nitrogen was chemisorbed on a ruthenium black catalyst by a plasma discharge of N2. Temperature-programmed desorption of nitrogen showed a broad peak at around 300 °C which showed a dependence on the duration and the wattage of the discharge. The chemisorbed nitrogen species was reacted with hydrogen to form NH3 even at room temperature.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Protoplasma 128 (1985), S. 147-156 
    ISSN: 1615-6102
    Keywords: Cucurbita moschata ; Etioplast ; Prolamellar body ; SEM (Scanning electron microscopy) ; Tilting observation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary High resolution scanning electron microscopy revealed that the basic unit of the paracrystalline network in squash prolamellar body is a tetrapodal structure, which has four short tubular arms meeting at one point with equal angle. Fractured faces of the prolamellar bodies displayed three lattice forms; hexagonal, square and zigzag (distorted hexagonal) lattices. Tilting observations of the ultrathin sections, together with scanning electron microscope observations, showed that the paracrystalline tubular network in the squash prolamellar body is of zincblende-type. A pentagonal configuration of the network was sometimes observed. Many prolamellar bodies were also very often observed, which displayed two or three different lattice forms in a single prolamellar body. It became evident from these observations that most, if not all, of the prolamellar bodies in the squash etioplasts are paracrystalline network of spinel-type twin which is composed of two or more domains of zincblende-type. We propose a three dimensional model of the squash prolamellar body in which five paracrystal domains of zincblende-type are assembled around a pentagonal column at the center and connected by boundary lattice layers of wurtzite-type.
    Type of Medium: Electronic Resource
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