ISSN:
1434-0879
Keywords:
Ureterosigmoidostomy
;
Colon carcinoma
;
Carcinogenesis
;
Nitrosamines
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Urinary diversion in both a rat model for ureterosigmoidostomy and in ureterosigmoidostomy patients result in an increased incidence of colon tumours. Bacterial and chemical investigations on feces-urine mixtures from both the rat model and ureterosigmoidostomy patients showed the presence of a complex nitrate-reducing bacterial flora in both rats and humans. This bacterial flora actively reduced urinary nitrate to nitrite in humans and increased the endogenous formation of N-nitroso compounds. No evidence of urinary nitrate reduction and increased nitrosamine formation in the rectosigmoid of rats was found. The results support the N-nitrosamine theory of carcinogenesis of the colon following ureterosigmoidostomy in humans, but not in rats. As the rat model induces colon carcinomas, factors other than the increased endogenous formation of N-nitroso compounds in the rectosigmoid may contribute to the initiation of colon carcinomas following ureterosigmoidostomy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00302472
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