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  • 1
    Electronic Resource
    Electronic Resource
    Stauffer's syndrome in renal cell carcinoma evidence for intravascular coagulation (1980)
    Springer
    Journal of molecular medicine 58 (1980), S. 91-97 
    Details
    ISSN: 1432-1440
    Keywords: Hypernephrom ; Gamma-GT ; Alkalische Phosphatase ; Isoenzyme der alkalischen Phosphatase ; Prothrombinzeit ; Thrombinkoagulasezeit ; Alkoholtest ; Fibrinmonomerkomplexe ; Fibrinspaltprodukte ; Renal cell carcinoma ; Gamma-GT ; Alkaline phosphatase and isoenzymes ; Disseminated intravascular coagulation (DIC) ; Prothrombin time ; Thrombin coagulase time ; Ethanol gelation test ; Soluble fibrin monomer complexes ; Fibrin degradation products
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In 40 patients with non-metastasising (n=31) and metastasising (n=9) renal cell carcinoma, evidence of Stauffer's syndrome (increase in alkaline serum phosphatase and prolongation of prothrombin time) was found in 18 patients. Prolongation of prothrombin time was not due to depletion of vitamin K-dependent coagulation factors or manifest fibrinolysis, but due to the presence of circulating fibrinogen fibrinmonomer-FDP complexes. Ethanol gelation test was found to be positive in 28/40 subjects and soluble fibrin monomer complexes were increased in 38/40 patients. The resulting disturbance of fibrinogen-fibrin conversion was reflected by an increase in thrombin coagulase time and reptilase time. These findings suggests a state of latent compensated intravascular coagulation (presumably triggered within the vascular tumor). For diagnostic purposes the most sensitive indicator is thrombin coagulase time. Thrombin coagulase time normalised after tumor resection and was positive in patients with recurrent metastases. The increase in alkaline serum phosphatase was due to an increase in the hepatic isoenzyme. Such an increase was much more common than the elevation of total alkaline serum phosphatase. Regan's isoenzyme was only found in 1 subject. In parallel, gamma-GT was elevated in 24 patients. The study shows that Stauffer's syndrome occurs more frequently than commonly assumed when thrombin coagulase time, gamma-GT and the hepatic isoenzyme of alkaline serum phosphatase are determined in patients with renal cell carcinoma. DIC and low grade fibrinolysis may account for the coagulation abnormalities of the syndrome.
    Notes: Zusammenfassung Ein Stauffer-Syndrom (erhöhte alkalische Phosphatase und verlängerte Prothrombinzeit) wurde bei 18 von 40 Hypernephrom-Patienten gefunden. Es konnte gezeigt werden, daß die verlängerte Prothrombinzeit nicht auf eine Verminderung Vitamin K-abhängiger Gerinnungsfaktoren, sondern auf zirkulierende Fibrinogen-Fibrinomer-Fibrinspaltproduktkomplexe zurückzuführen ist. Der Alkoholtest nach Godal war bei 28 von 48 Patienten positiv und erhöhte Mengen an zirkulierenden Fibrinmonomeren wurden bei 38 von 40 Patienten gefunden. Eine gesteigerte Fibrinolyse ließ sich in 19 von 40 Patienten nachweisen. Die Verlängerung der Thrombinkoagulase-und Reptilasezeit wird auf die zirkulierenden Fibrinmonomer-Fibrinspaltproduktkomplexe zurückgeführt, die die gestörte Umwandlung von Fibrinogen in Fibrin verursachen. Die vorliegenden Befunde sprechen für eine latente kompensierte intravasale Verbrauchskoagulopathie, die wahrscheinlich innerhalb des gefäßreichen Tumors ausgelöst wird. Als empfindlicher Indikator für diagnostische Zwecke erwies sich die Thrombinkoagulasezeit. Die Thrombinkoagulasezeit normalisierte sich nach chirurgischer Entfernung des Tumors und wurde nach Auftreten von Metastasen wieder pathologisch. Die Erhöhung der alkalischen Phosphatase war in der Regel nur auf einen Anstieg des hepatischen Isoenzyms zurückzuführen. Zum Nachweis des Stauffer-Syndroms erwiesen sich das hepatische Isoenzym der alkalischen Phosphatase und die Gamma-GT empfindlicher als die Gesamt-alkalische Phosphatase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01477193
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  • 2
    Electronic Resource
    Electronic Resource
    Prevention of p.o. clotting of av. cimino fistulae with Acetylsalicyl acid results of a prospective double blind study (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 348-349 
    Details
    ISSN: 1432-1440
    Keywords: Acetylsalicylic acid ; platelets ; thrombosis ; Cimino fistula ; uremia ; Acetylsalicylsäure ; Thrombocyten ; Thrombose ; Cimino-Fistel ; Urämie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In einer prospektiven Doppelblindstudie wurde der Einfluß von Acetylsalicylsäure auf die Häufigkeit von Cimino-Fistelthrombosen in der ersten p.o. Phase untersucht. Durch prophylaktische Gabe von Acetylsalicylsäure ließ sich der thrombotische Fistelverschluß auf 4% senken (Placebogruppe: 23%). Ein erhöhtes Thromboserisiko bestand bei schlechtem arteriellen Blutfluß, weiblichem Geschlecht und vorausgegangenen erfolglosen Fisteloperationen. Die Nebenwirkungen von Acetylsalicylsäure waren vertretbar, sofern Aspirin in niedriger Dosierung und in Verbindung mit Antacida verabreicht wurde.
    Notes: Summary In a prospective double blind study prophylactic administration of Acetylsalicylic acid (ASA) in low doses decreased significantly the rate of fistula clotting in the immediately p.o. period in uremic patients. The risk of fistula clotting was related to poor arterial blood flow, female sex and number of unsuccessful previous fistula operations. The incidence of side effects (g.i. and non g.i. bleeding) was acceptable with low doses of ASA and prophylactic administration of antacids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468835
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  • 3
    Electronic Resource
    Electronic Resource
    Haemodialysis in imipramine poisoning? (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 83-87 
    Details
    ISSN: 1432-1440
    Keywords: Imipramin-Vergiftung ; Hämodialyse ; Imipramin-Clearance ; Polyvinylchlorid ; Imipramine intoxication ; Haemodialysis ; Imipramine clearance ; Polyvinylchloride
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In the last several years an increasing number of severe imipramine intoxications have been observed. Though standard principles for the treatment of acute tricyclic poisoning have been established, nonetheless there still exists doubt on the most effective method of tricyclic removal in cases of massive overdose. Haemodialysis was successfully employed until now but has not found general acceptance as only insignificant amounts of imipramine could be recovered from the dialysate. An experimental clearance study was undertaken using radiolabelled imipramine (14C-I) to obtain insight into the usefullness of haemodialysis in imipramine poisoning.14C-I clearances which were calculated in a closed circuit dialysis system ranged between 18 ml/min and 48 ml/min depending on the constitution of the dialysate, i.e. aqueous or lipid solution. Surprisingly a rapid and significant uptake of imipramine by the plastic material (polyvinylchloride) of the extracorporeal blood line system was detected. This escape of imipramine from the blood into the tubings explains the poor recovery of tricyclics from the dialysate, which discredited haemodialysis as a therapeutical method in imipramine poisoning. The results of our experiments may offer a new method of rapid tricyclic elimination in severe imipramine intoxications.
    Notes: Zusammenfassung In den letzten Jahren wurde eine zunehmende Zahl schwerer Imipramin-Intoxikationen beobachtet. Obwohl die Behandlung der akuten Vergiftung mit tricyclischen Antidepressiva weitgehend standardisiert ist, besteht nach wie vor Unsicherheit über die effektivste Methode zur raschen Elimination dieser Substanzen. Trotz klinischer Erfolge konnte die Hämodialyse im Behandlungsschema der schweren Imipramin-Vergiftung bislang keinen festen Platz behaupten, da der Nachweis nennenswerter Imipramin-Mengen im Dialysat nicht gelang. In einer experimentellen Studie wurde die Clearance von radiomarkiertem Imipramin (14C-I) im geschlossenen Dialysesystem untersucht. Die Clearance bewegte sich zwischen 18 ml/min und 48 ml/min in Abhängigkeit von der Zusammensetzung des Dialysats (wäßrige oder fetthaltige Lösung). Überraschenderweise fand sich eine rasche und erhebliche Aufnahme von Imipramin durch das extrakorporale Blutschlauchsystem (Polyvinylchlorid). Die „Sorption“ von Imipramin durch die blutführenden Schläuche erklärt die Unmöglichkeit des Imipramin-Nachweises im Dialysat bei klinischen Dialysen. Die Ergebnisse unserer Untersuchungen eröffnen möglicherweise ein neues Behandlungsprinzip bei schwerer Imipramin-Vergiftung und/oder Vergiftungen mit anderen tricyclischen Aminen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468773
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  • 4
    Electronic Resource
    Electronic Resource
    Generalized amyloidosis secondary to xanthogranulomatous pyelonephritis (1986)
    Springer
    European journal of pediatrics 145 (1986), S. 565-568 
    Details
    ISSN: 1432-1076
    Keywords: Pyelonephritis ; xanthogranulomatous ; Amyloidosis ; Chronic renal failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Unilateral nephrectomy in an 8-year-old male with chronic renal failure and urosepsis revealed a combined histologic lesion of xanthogranulomatous pyelonephritis and amyloidosis. Amyloid deposits were found also in the rectum and liver. On clinical grounds xanthogranulomatous pyelonephritis was also suspected in the remaining kidney. Common causes of systemic amyloidosis were excluded. After operation the signs of amyloidosis diminished, probably due to removal of the infected kidney, but renal function deteriorated rapidly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02429068
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  • 5
    Electronic Resource
    Electronic Resource
    Changning pattern of chronic renal failure and renal replacement therapy in children and adolescents: a 20-year single centre study (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 166-171 
    Details
    ISSN: 1432-1076
    Keywords: Chronic renal failure ; Haemodialysis ; Continuous ambulatory peritoneal dialysis ; Renal transplantation ; Survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We analysed the demographic data, clinical course and survival on different forms of renal replacement therapy (RRT) of 374 children and adolescents with chronic renal failure observed between 1969 and 1988 and compared the findings for the four subsequent 5-year periods. The proportion of children below 5 years of age rose from 21% to 47%. With time the incidence of glomerulonephritis increased and that of pyelonephritis decreased. As RRT became more common, more very young children and more adolescents were admitted to the study. In the last 5 years continuous ambulatory peritoncal dialysis (CAPD) and haemodialysis (HD) were performed to the same extent as the initial form of RRT. The time a subject had to wait for a first transplant decreased from 36 to 21 months. Between 1969 and 1988 overall survival on any form of RRT increased to 77% after 10 years of therapy. In the last observation period 2-year patient survival was 100% both on HD and CAPD. First cadaver graft survival after 4 years improved from 25% in 1969–1973 to 69% in 1984–1988.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02072498
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  • 6
    Electronic Resource
    Electronic Resource
    Results of endoscopic subureteral collagen injection for reflux correction in pigs and dogs (1991)
    Springer
    Pediatric surgery international 6 (1991), S. 261-262 
    Details
    ISSN: 1437-9813
    Keywords: Endoscopic correction ; Vesicoureteral reflux ; Bovine collagen ; Animal experiments ; Histological evaluation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The efficacy of endoscopic correction of reflux with the use of Teflon has been proven, but there are safety concerns because of granuloma formation and particle migration. Using glutaraldehyde cross-linked (GAX-) bovine collagen as an alternate biomaterial, animal experiments were performed with 6 female pigs and 20 beagle dogs. Primary and experimentally-induced vesicoureteral reflux was treated by endoscopic injection of bovine GAX-collagen (Zyplast) submucosally at the ureteric orifice. Radiographic controls after 6, 8, or 12 months revealed successful reflux correction in 14 of 19 treated ureters of dogs. After the animals were killed, pathohistological evaluation demonstrated persistence of the collagen depot at the site of injection even after 12 months, although not in all cases, without inflammatory or foreign-body tissue reaction. No evidence of particle migration was found. Invasion of fibroblasts and fibrocytes into the collagen depot and capillary vessel formation appeared the same after the different time intervals, and there was no difference between the two animal species. The biocompatibility of purified bovine GAX-collagen makes it an alternative to Teflon for reflux correction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00178632
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  • 7
    Electronic Resource
    Electronic Resource
    Voltaspannungen zwischen Gewebesaft von Krebsgewebe und entsprechendem physiologischem Gewebe (1955)
    Springer
    Naturwissenschaften 42 (1955), S. 74-75 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00589545
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  • 8
    Electronic Resource
    Electronic Resource
    Progression to end-stage renal disease in children with posterior urethral valves (1998)
    Springer
    Pediatric nephrology 12 (1998), S. 630-636 
    Details
    ISSN: 1432-198X
    Keywords: Key words: Posterior urethral valves ; Chronic renal failure ; Obstructive uropathy ; Serum creatinine ; Renal function ; Renal dysplasia/hypoplasia ; Body growth
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Diagnostic and therapeutic strategies in boys with congenital posterior urethral valves (PUV) have much improved in past decades, but the impact of these changes on the progression to end-stage renal disease (ESRD) has rarely been investigated. We followed renal function in 20 boys with PUV from diagnosis to ESRD. From the first observation period (1969–1978) to the second period (1979–1992) we found a marked drop in age at diagnosis, at valve resection, at first increase of serum creatinine (SCr), and at onset of ESRD. The progression was analyzed by calculating the slope of 1/SCr and the probability of renal survival. In all patients combined, renal survival at the age of 10 years was 35%. In children undergoing valve resection in the 1st year of life, renal survival was worse than in those undergoing later surgery (15% vs. 65% after 10 years, P=0.006). Patients with a SCr〉1.2 mg/dl before the age of 12 months progressed more rapidly to ESRD than those attaining this level later. The lower the minimum level of SCr observed after initial surgery, the older the patient at the onset of ESRD. The presence of renal dysplasia or hypoplasia, but not of vesicoureteric reflux, was associated with a more rapid progression. Mean body height at ESRD was −2.3±1.3 standard deviation score compared with controls, and was lower if PUV was diagnosed before the age of 6 months.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670050517
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  • 9
    Electronic Resource
    Electronic Resource
    The role of nitrate, nitrite and N-nitrosamines in carcinogenesis of colon tumours following ureterosigmoidostomy (1990)
    Springer
    Urological research 18 (1990), S. 123-129 
    Details
    ISSN: 1434-0879
    Keywords: Ureterosigmoidostomy ; Colon carcinoma ; Carcinogenesis ; Nitrosamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Urinary diversion in both a rat model for ureterosigmoidostomy and in ureterosigmoidostomy patients result in an increased incidence of colon tumours. Bacterial and chemical investigations on feces-urine mixtures from both the rat model and ureterosigmoidostomy patients showed the presence of a complex nitrate-reducing bacterial flora in both rats and humans. This bacterial flora actively reduced urinary nitrate to nitrite in humans and increased the endogenous formation of N-nitroso compounds. No evidence of urinary nitrate reduction and increased nitrosamine formation in the rectosigmoid of rats was found. The results support the N-nitrosamine theory of carcinogenesis of the colon following ureterosigmoidostomy in humans, but not in rats. As the rat model induces colon carcinomas, factors other than the increased endogenous formation of N-nitroso compounds in the rectosigmoid may contribute to the initiation of colon carcinomas following ureterosigmoidostomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00302472
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  • 10
    Electronic Resource
    Electronic Resource
    Low-dose cyclosporin A therapy in cadaver renal transplantation in children (1989)
    Springer
    Transplant international 2 (1989), S. 203-208 
    Details
    ISSN: 1432-2277
    Keywords: Pediatric renal transplantation ; Cyclosporin, low-dose, in children ; Growth, cyclosporin, in kidney transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fifty-one pediatric patients undergoing a first cadaveric kidney transplantation were followed for at least 2 years after grafting. They were divided into two groups: those treated with methylprednisolone plus azathioprine (AZA) and those treated with methylprednisolone plus low-dose cyclosporin A (CyA; median dose 109 mg/m2 per day ≙ 3.4 mg/kg per day after 1 year). The steroid dosage given was significantly lower in the second group. The 4-year graft survival rate was 68% for the AZA group and 78% for the CyA group. Renal function did not differ significantly in the two groups; after 1, 2, and 3 years, the median 24-h creatinine clearance was 79, 69, and 51 ml/min/1.73 m2, respectively, for the AZA group and 78, 63, and 68 ml/min/1.73 m2, respectively, for the CyA group. Linear growth was similar in the two groups. We conclude that in pediatric patients the results of low-dose CyA immunosuppression do not differ significantly from those obtained with AZA in terms of graft survival, renal function, or growth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02414535
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