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  • Electronic Resource  (2)
  • 1990-1994  (2)
  • Anti-Fab Antibody  (1)
  • Methotrexate  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Methotrexate for steroid-resistant systemic lupus erythematosus (1994)
    Springer
    Clinical rheumatology 13 (1994), S. 280-283 
    Details
    ISSN: 1434-9949
    Keywords: Systemic Lupus Erythematosus ; Methotrexate ; Steroid-resistance ; Surface Markers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We here report two patients with steroid-resistant systemic lupus erythematosus (SLE) who were successfully treated with methotrexate (MTX). In both cases, a steroid resistant high fever, associated with mild myositis and pancytopenia were the main common findings, and all these symptoms were alleviated within a few days either by 7.5 mg or 5 mg MTX per week. The number of CD4+ cells increased along with the clinical improvement, whereas the number of CD20+ cells and HLA-DR expressing cells also decreased. Taking into account the side effects of high dose corticosteroids and cyclophosphamides, treatment with a weekly low dose of MTX is known to contribute to an improvement in the long-term prognosis for patients with refractory SLE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02249027
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The specificity of antiglobulin autoantibodies in patients with primary Sjögren's syndrome (1990)
    Springer
    Clinical rheumatology 9 (1990), S. 501-508 
    Details
    ISSN: 1434-9949
    Keywords: Rheumatoid Factor ; Anti-Fab Antibody ; Primary Sjögren's Syndrome ; ELISA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Antiglobulin autoantibodies have already been demonstrated in the sera of patients with primary Sjögren's syndrome (primary SS). In our study, the specificity of primary SS antiglobulins for different regions IgG molecules was examined by employing both direct binding and competitive inhibition enzymelinked immunosorbent assay. We found that a considerable amount of total antiglobulins in primary SS was specific for the Fab portion, although the remainder was specific for the Fc portion, namely rheumatoid factor (RF). In contrast, most of the antiglobulins in RA were specific for the Fc portion of IgG. These results indicate that in primary SS, antiglobulins directed against epitopes different from those of RF are produced. These antiglobulins may prove to have a different role in primary SS than that ascribed to RF in RA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02030512
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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