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  • Electronic Resource  (2)
  • 1990-1994  (2)
  • Arsenic compounds  (1)
  • glucagon  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Glutathione plays different roles in the induction of the cytotoxic effects of inorganic and organic arsenic compounds in cultured BALB/c 3T3 cells (1994)
    Springer
    Cellular and molecular life sciences 50 (1994), S. 115-120 
    Details
    ISSN: 1420-9071
    Keywords: Arsenic compounds ; cytotoxicity ; BALB/c 3T3 cells ; glutathione depletion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The cytotoxicity of arsenic compounds towards BALB/c 3T3 cells in culture was investigated, together with the role of glutathione (GSH) in the induction of the cytotoxic effects. The rank order of cytotoxicity was as follows: arsenite (As3+)〉arsenate (As5+)〉dimethylarsinic acid (DMAA)〉methylarsonic acid (MAA)〉trimethylarsine oxide (TMAO). Arsenobetaine, arsenocholine and the tetramethylarsonium ion were less toxic. Depletion of GSH enhanced the cytotoxic effects of As3+, As5+, MAA and TMAO, while the cytotoxicity of DMAA was markedly reduced by depletion of GSH. These results suggest that GSH plays a role in protecting the cells against the toxic effects of As3+, As5+, MAA and TMAO while it is involved in the induction of the cytotoxic effects of DMAA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01984946
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Insulin and glucagon therapy of acute hepatic failure (1991)
    Springer
    Digestive diseases and sciences 36 (1991), S. 809-815 
    Details
    ISSN: 1573-2568
    Keywords: insulin ; glucagon ; acute hepatic failure ; liver regeneration ; polyamine ; ornithine decarboxylase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract When insulin and glucagon are administered to rats with severe liver injury, survival is enhanced with an attenuation of the liver injury compared to that of untreated controls. In rats with acute liver injury both hormones produce a rapid normalization of hepatic protein content following initiation of DNA synthesis. When rats receive both hormones after partial hepatectomy, the first burst of DNA synthesis reaches a maximum earlier than that seen in controls. Both hormones enhance the increment of hepatic putrescine essential for DNA synthesis through activation of ornithine decaroxylase and/or spermidine-N1-acetyltransferase. The enhancement of putrescine content by each hormone is additive. Putrescine supplementation promotes hepatic DNA synthesis after hepatectomy. Based on these data, we conclude that a combination of insulin, and glucagon is effective in the therapy of acute hepatic failure in rats. The restoration of liver function as well as the stimulation of liver cell proliferation via putrescine production may contribute to this effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01311241
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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