Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Regulatory aspects of nigrostriatal dopaminergic neurons (1992)
    Springer
    Experimental brain research 91 (1992), S. 489-495 
    Details
    ISSN: 1432-1106
    Keywords: Regulation ; Synthesis ; Release ; Dopamine ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the urethane-anesthetized rat, electrical stimulation (10 Hz, 30 s, 250 μA) of the medial forebrain bundle (MFB), at 20-min intervals over an 8-h period, combined with intracerebral microdialysis in the striatum caused: an undiminished increase in the release of dopamine (DA) with each stimulation episode; a decreased efflux of 3,4-dihydroxyphenylacetic acid (DO-PAC) and 4-hydroxy-3-methoxyphenylacetic acid (HVA) after the first stimulation only; a delayed increased efflux of DOPAC with no change in HVA; and a poststimulation depression of firing of dopaminergic neurons in the substantia nigra (before, 3.1±0.7 Hz; after, 1.9±1.0 Hz; P〈0.05). After the last stimulation episode, the release of DA declined to prestimulation values, while the increased efflux of DOPAC persisted for three more hours. After the infusion of tetrodotoxin (4.0×10-7 M, 1.5 μl, 1.0 μl/min) into the MFB, the basal release of DA was reduced (P〈0.05), while the efflux of DOPAC and HVA was increased (P〈0.05). A model is proposed suggesting that: (1) during increased release of DA in the striatum, the metabolism of DA is decreased; (2) inhibition of nigrostriatal dopaminergic neurons is the usual cause of increased synthesis and metabolism of DA in the striatum; and (3) increased release of DA, and increased synthesis and metabolism of DA in the striatum are not causally linked and are noncoupled processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227845
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Effects of raclopride treatment on plasma and CSF HVA: relationships with clinical improvement in male schizophrenics (1994)
    Springer
    Psychopharmacology 116 (1994), S. 291-296 
    Details
    ISSN: 1432-2072
    Keywords: Schizophrenia ; Antipsychotics ; Dopamine ; Raclopride
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thirty-two acutely psychotic, male schizophrenic patients received raclopride, at 2, 6, or 12 mg/day, or haloperidol, 15 mg/day for 4 weeks after randomized, double-blind assignment. Twenty-six patients, including 19 who had been assigned one of the three doses of raclopride, completed the study. Raclopride, particularly at 12 mg/day, increased CSF homovanillic acid (HVA) at 4 weeks, and plasma HVA at 2 days, of treatment. The clinical response to raclopride was significantly correlated with plasma raclopride concentrations and baseline plasma HVA concentrations. Although raclopride is a substituted benzamide with atypical properties in animals, these results suggest that the doses of raclopride required for clinical efficacy and elevation of clinical indices of brain dopamine turnover are similar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245331
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Subcortical dopamine and serotonin turnover during acute and subchronic administration of typical and atypical neuroleptics (1993)
    Springer
    Psychopharmacology 110 (1993), S. 145-151 
    Details
    ISSN: 1432-2072
    Keywords: Dopamine ; Serotonin ; Neuroleptics ; Clozapine ; Sulpiride ; 3-PPP ; Haloperidol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of acute (1 day) and subchronic (28 days) treatment with three atypical antipsychotic drugs [clozapine, (±)-sulpiride and (−)-3-PPP] on dopamine and serotonin turnover in both the nucleus accumbens (NA) and corpus striatum (CS) of rodents was compared to haloperidol and saline treatment. The equivalent doses of all drugs were determined based upon their ability to compete in vivo for3H-spiperone binding in the NA and CS. All three atypical drugs, compared to haloperidol, produced preferential elevations of dopamine turnover in the NA. Further, the development of tolerance to this effect was more apparent for the three atypical drugs than for haloperidol. Surprisingly, all three atypical drugs, but not haloperidol, produced changes in serotonin turnover, despite the fact that (±)-sulpiride and (−)-3-PPP have no known direct effects on brain serotonin systems. All three atypical drugs produced acute increases in serotonin turnover in both the NA and CS, followed by later decreases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02246964
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Brain dopamine receptors: 20 Years of progress (1993)
    Springer
    Neurochemical research 18 (1993), S. 101-104 
    Details
    ISSN: 1573-6903
    Keywords: Dopamine ; dopamine receptors ; A68930 ; A77636 ; Parkinson's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract I present a brief overview of the contribution of Paul Greengard's laboratory to the field of dopamine receptor research. I show that the work on the biochemical pharmacology of dopamine receptors was part of the intellectual foundation for the division of dopamine receptors into two general pharmacological categories.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00966928
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Lösliche Lanthanid-alkoxide mit niedrigen Koordinationszahlen am Metall-Atom (1991)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 124 (1991), S. 1163-1165 
    Details
    ISSN: 0009-2940
    Keywords: Lanthanide alkoxides ; Tritox ligand ; Neodymium ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Soluble Lanthanide Alkoxides with Low Coordination Numbers at the Metal AtomNd[N(SiMe3)2]3(thf)2 (1) reacts with tBu3COH (2) to give the monomeric lanthanide alkoxide (tritox)3Nd(thf) (3). The chloro-bridged dimer [(tritox)2Nd(μ-Cl)thf]2 (6) is obtained by treatment of NdCl3(thf)2 (4) with LiOCtBu3 (5). The structure of 6 has been determined by X-ray crystallography.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19911240530
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Synthese und Strukturen von metallhaltigen achtgliedrigen N  -  S  -  O-Heterocyclen (1991)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 124 (1991), S. 1917-1921 
    Details
    ISSN: 0009-2940
    Keywords: Aluminium heterocycles ; Gallium heterocycles ; Indium heterocycles ; NSO complexes ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Synthesis and Structures of Metal-Containing Eight-Membered N  -  S  -  O HeterocyclesRacemic N-alkylsulfinamides 1a, b react with aluminium, gallium, and indium alkyls 2a  -  d to form puckered eight-membered NSO-complexes [Me2AlN(CF3)2C6H3S(tBu)O]2 (3a), [Me2AlN-(Ph)S(tBu)O]2 (3b), [Me2GaN(CF3)2C6H3S(tBu)O]2 (3c), [(Me3- SiCH2)2GaN(CF3)2C6H3S(tBu)O]2 (3d), [(Me3SiCH2)2InN(Ph)S- (tBu)O]2 (3e), and [(Me3SiCH2)2InN(CF3)2C6H3S(tBu)O]2 (3f). Compounds 3a, c, d crystallize in the triclinic space group P¯1. A comparision of the X-ray structures of 3a, c, d reveals that the sulfur atoms in one molecule of 3d have either (R,R) or (S,S) configuration (Z = 2). In the case of less bulky ligands at the metal atoms (3a, c) both configurations at the sulfur atoms (R,S) are present in one molecule (Z = 1).
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19911240906
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...