ISSN:
1420-9071
Keywords:
Monocytes
;
fever
;
endogenous pyrogen
;
polyriboinosinic acid:polyribocytidylic acid
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The pyrogenic response to supernatants from human blood monocytes stimulated with polyriboinosinic acid:polyribocytidylic acid (poly I:C) was characteristic of a response to endogenous pyrogen in that it was brief and monophasic, and was destroyed by heating the supernatants at 70°C for 30 min. Pyrogen production was unimpaired when the incubations were carried out in the presence of cycloheximide (50 μg/ml; an inhibitor of protein synthesis) or indomethacin (50 μg/ml; an inhibitor of prostaglandin synthesis). Also, neither interferon, interleukins, tumor necrosis factor nor prostaglandin E2 were detectable in the supernatants from the poly I:C-stimulated human monocytes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01989421
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