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  • 1
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 97 (1992), S. 9016-9030 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: In a crossed molecular beam experiment, we have measured the angular and time-of-flight (TOF) distributions of the products KCl and KI formed in the reaction K+ICl→KI+Cl, KCl+I at an elevated collision energy of Etr=1.64 eV. Employing the brute force method, we have prepared an oriented ICl beam and studied in addition also the orientation dependence of these distributions. The results are (i) KCl is the dominant product, but also KI is substantially formed with a branching ratio of 4:1; (ii) the double differential reaction cross section in the center-of-mass frame (contour maps) indicates that all products are preferentially forward scattered and constrained to the forward hemisphere; (iii) the KCl flux consists of two distinct components which differ markedly in kinetic energy and dependence on the ICl orientation; there are also indications of the existence of two components of KI; (iv) 65%, 84%, and 64% of the available energy is vested into the internal degrees of freedom for the fast, slow component of KCl and KI, respectively; (v) the existence of two components can be rationalized on the basis of the harpooning mechanism where the jumping electron accesses the ground state or one of the low excited states of the ICl− ion and triggers the subsequent explosion of the ion with more or less kinetic energy of the fragments depending on the initially populated state; (vi) the energies released during dissociation of ICl− in the 2Σ ground state and the first 2Π state are ≤0.19 and ≤1.2 eV, respectively; (vii) the fast KCl component features a negative steric effect suggesting favorable product formation for attacks of K to the I end of ICl, the steric effect of the slow KI component is positive, i.e., attacks to the Cl end form products favorably; the other components exhibit no significant steric effect; (viii) the steric effects can be quantitatively rationalized using the same model as mentioned above; (ix) the magnitude of the steric effect suggests a rotational temperature of the low-lying states of the ICl beam of 14±1 K.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 61 (1993), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Border disease (BD) of sheep is caused by a virus in the genus Pestivirus that results in decreased myelination throughout the CMS when acquired congenitally. Pregnant ewes were inoculated with BD virus at 50 days of gestation, and myelin proteins were quantified in several regions of the CNS during prenatal and postnatal development of infected lambs for comparison with age-matched controls. Newborn field-infected lambs were also examined. Myelin basic protein (MBP), proteolipid protein (PLP), myelin-associated glycoprotein (MAG), and 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP) were measured by densitometric scanning of western blots. Deficiencies in the myelin proteins were detected as early as 116 days of gestation, and the deficiencies of myelin proteins were most pronounced in the cerebellum at all ages examined. PLP and MBP increased from 10–30% of normal in cerebellar white matter at birth to 40–60% of normal at 6 months, suggesting some catch-up in the amount of compact myelin with development. MAG and CNP were between 70 and 80% of control levels in the cerebellum at birth and at 6 months. Similar results were obtained for the corpus callosum and spinal cord of infected lambs, but the deficiencies of myelin proteins were not as great. A common finding in all regions examined was that MBP and PLP were reduced more than MAG and CNP. This is probably explained by a greater deficit of compact myelin, in which MBP and PLP are localized, than of associated oli-godendroglial membranes, in which MAG and CNP are concentrated. Similar results have been obtained in several dysmyelinating mutants, pointing to common factors in virally and genetically caused hypomyelination. Key Words: Border disease—Myelin—Hypomyelination—Development—Sheeo.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 97 (1993), S. 2158-2166 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 114 (1992), S. 1876-1877 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Activation and proliferation of microglia are common cellular hallmarks in many different pathological processes of the central nervous system. Although a number of colony-stimulating factors enhance microglial proliferation in vitro, little is known about the endogenous mitogens. In the present study we show a strong and selective inhibition of microglial proliferation in the facial nucleus of osteopetrotic (op/op) mice, with a genetic deficiency in biologically active macrophage colony-stimulating factor (MCSF). Posttraumatic activation of adjacent axotomized neurons and reactive astrocytes was not affected, emphasizing the specificity of MCSF as a microglial growth factor.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric radiology 21 (1991), S. 521-522 
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A preterm infant with severe hyaline membrane disease requiring extreme mechanical ventilation developed pulmonary air leaks with consecutive shock. The chest roentgenogram showed bilateral pulmonary interstitial emphysema and gas within the heart silhouette as well as in the hepatic veins, inferior v.cava, portal vein, and many abdominal vessels. The respiratory and circulatory failure by massive systemic gas embolism resulted in death.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 103 (1990), S. 311-312 
    ISSN: 1437-1596
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary The influence of stirrer speed in the third preculture on the performance of penicillin V production by Penicillium chrysogenum in complex medium in a 100-l air-lift tower loop reactor was investigated. The process performance in the main culture was improved by increasing the stirrer speed from 500 to 750 rpm: the pellet size was reduced to half, the cell growth was influenced only slightly, but the production phase was extended considerably, and the final penicillin concentration was increased from 5.1 g 1-1 to 10.4 g 1-1.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1076
    Keywords: Teratogen ; Cytostatic drugs ; Pregnancy ; Craniosynostosis Radius aplasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Experience with the use of cytotoxic drugs in the first trimester of pregnancy is limited. We report on the clinical phenotype and infantile development of a girl born to a 36-year-old mother. Before recognition of pregnancy, the latter had been treated for acute myelocytic leukaemia receiving cytarabine, daunorubicin and doxorubicin at conception and cytarabine and thioguanine at about 35–37 days post conception. At delivery, there were severe brachycephaly, hypoplasia of the anterior cranial base and the midface as well as synostoses of both coronal and metopic sutures. Further findings included bilateral four-finger hands with hypoplastic thumbs and absent radii. This phenotype is reminiscent of the Baller-Gerold syndrome. The child, at present 15 months old, has had to undergo two operations for fronto-orbital advancement because of insufficient growth of the mid-face, nasal airway hypoplasia and increased intracranial pressure. Motor milestones are slightly retarded—neurodevelopment is otherwise normal. These findings are discussed in the context of the few previous reports and are particularly important for future genetic counselling.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    European spine journal 1 (1992), S. 178-184 
    ISSN: 1432-0932
    Keywords: Rachis cervical supérieur ; Ligament alaire ; Ligament transverse ; Anatomie ; Biomécanique ; Upper cervical spine ; Alar ligament ; Transverse ligament ; Anatomy ; Biomechanics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The occipito-atlanto-axial joint is the most complex one of the human spine. Traumatic or inflammatory lesions in this region may lead to instability and neurological symptoms of clinical importance. This study reports the results of anatomical and biomechanical examination of 13 human upper cervical spine specimens and focuses on the viscoelastic behavior of the alar and transverse ligaments. Non-destructive tensile testing was performed on a uniaxial testing machine with 25 alar and 11 transverse ligaments at three different load rates of 0.1 mm/s, 1.0 mm/s, and 10.0 mm/s. The ligaments were further tested for relaxation over 300 s. Each ligament exhibited an initial neutral zone in which no tensile force could be measured during cyclic testing. This neutral zone was more significant in the alar ligaments than in the transverse ligaments with respect to the measured in situ length of the ligaments (11.2 vs 18.1 mm on average). Increasing axial deformation led to increased load in all ligaments. Hysteresis, i.e., the energy loss exhibited by viscoelastic material subjected to loading and unloading cycles, increased with higher displacement rates and higher tensile forces. In neutral position the alar ligaments were lax in all specimens. During axial rotation both alars tightened. Ligamentous resistance increased as the end of the range of motion (ROM) was approchaed during rotation. The neutral zone explains the laxity of the ligaments in midposition and allows mobility of the upper cervical spine with minimum expenditure of muscular energy. The ligaments become stiffer under higher loads and therefore contribute to a limitation of the ROM in the occipitio-atlanto-axial joint.
    Notes: Résumé L'articulation occipito-atlanto-axoïdienne est l'une des plus complexes du rachis humain. Les lésions traumatiques ou inflammatoires de cette région peuvent conduire à l'instabilité et à des troubles neurologiques importants. Cette étude rapporte les résultats d'une étude anatomique et biomécanique de 13 spécimens de rachis cervical supérieur et met l'accent sur le comportement visco-élastique des ligaments alaires et transverse. Des essais de mise en tension ont été réalisés sur 25 ligaments alaires et 11 ligaments transverses, en restant en deçà du point de rupture. Ils ont été effectués sur un appareil monoaxial, selon trois niveaux de charge différents: 0.1 mm/s, 1.0 mm/s et 10.0 mm/s. La détente ligamentaire a été en outre étudiée pendant 300s. Chaque ligament a montré une zone neutre initiale (NZ) dans laquelle aucune force de tension ne pouvait être mesurée au cours du cycle d'essai. Cette zone neutre était plus importante pour les ligaments alaires que pour les ligaments transverses, compte tenu de la longueur ligamentaire mesurée in situ (11.2 contre 18.1 mm en moyenne). L'augmentation de la déformation axiale a conduit à une augmentation des contraintes dans tous les ligaments. L'hystérésis, c'est à dire la perte d'énergie présentée par le matériel visco-élastique soumis à des cycles de mise en charge et décharge, augmentait avec l'amplitude du déplacement et l'intensité des forces de tension. En position neutre, les ligaments alaires étaient détendus sur tous les spécimens. Lors de la rotation axiale, les deux ligaments alaires se sont mis en tension. La résistance du ligament à la rotation s'est trouvée accrue en fin d'amplitude. La zone neutre explique la laxité des ligaments en position intermédiaire et permet la mobilité du rachis cervical supérieur avec un minimum de dépense d'énergie. Les ligaments se tendent sous des charges plus élevées et par conséquent contribuent à la limitation de ROM dans l'articulation occipito-atlanto-axoïdienne.
    Type of Medium: Electronic Resource
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