ISSN:
1744-313X
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Biologie
,
Medizin
Notizen:
The t haplotypes of mouse chromosome 17 bear a number of interesting mutations and rearrangements, some of which map close to the H-2 complex. Since there are many H-2 class I genes of unknown function, we have investigated their arrangement in t haplotypes using genomic Southern blots. We present a detailed chart of the H-2w30(tw12) complex, and compare it with the arrangement in other t haplotypes and standard mouse haplotypes. The chart shows duplications, deletions, and reshuffling of conserved and divergent regions. The two major features of the t arrangement-large deletions in the Qa and Tla regions–have analogues in some standard strains, so it is unlikely that these deletions are responsible for t-specific phenotypes. The differences between t and standard mouse strains are similar, in nature and in degree, to those between different standard strains.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1111/j.1744-313X.1985.tb00842.x
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