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  • Electronic Resource  (19)
  • 1980-1984  (10)
  • 1930-1934  (9)
Material
  • Electronic Resource  (19)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 6 (1982), S. 494-497 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Une nouvelle méthode d'insertion de tube oesophagien est proposée. Chez les malades qui présentent des tumeurs oesophagiennes sténosantes inopérables, l'introduction du tube au travers du cancer a pour but de supprimer la dysphagie et la salivation. La technique consiste d'abord à dilater le défilé tumoral par l'appareil de Eder-Puestow puis à introduire correctement le tube sous contrôle endoscopique. 28 malades ont bénéficié de l'introduction d'un tube dit de Célestin. La méthode n'est grevée que de rares complications. Elle représente une alternative aux méthodes chirurgicales d'introduction d'un tube endo-oesophagien.
    Notes: Abstract A new method for inserting endoesophageal tubes is described. In patients with stenosing, inoperable esophageal malignancies, a passage through the neoplastic masses must be secured to avoid dysphagia and salivation. By first dilating the tumor lumen with the Eder-Puestow apparatus and then inserting the correctly cut tube using endoscopic equipment, an operation can be avoided. In 28 patients, a Celestin tube was thus inserted. The method involved only a few complications. It can be recommended as an alternative to existing operative methods for endoesophageal intubation.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The clinical and biochemical abnormalities in a neonate, who died in coma accompanied by severe hypoglycaemia at the age of 3 days, are described. The study of the urinary metabolic profiles of organic acids and amino acids revealed that the excretion rates of glutaric acid, isovaleric acid, isovalerylglycine, 3-hydroxyisovaleric acid and isobutyric acid were very high. Increased excretion rates were also found for 2-methylbutyric acid, adipic acid, caproylglycine, 5-hydroxycaproic acid, caproic acid and butyric acid. The amino acid, sarcosine, was excreted in enhanced amounts and the patient had lactic aciduria, whereas the excretion of 3-hydroxybutyric acid was only moderately increased. This abnormal excretion pattern is consistent with a defect in the metabolism of acyl-CoAs and sarcosine. Normal activity of glutaryl-CoA dehydrogenase was found, excluding glutaryl-CoA dehydrogenase deficiency (glutaric aciduria type I).
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of inherited metabolic disease 4 (1981), S. 225-228 
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 2-year-old boy excreted massive amounts of formiminoglutamic acid in urine. The substance was identified as authentic formiminoglutamic acid by two-dimensional thin-layer chromatography, column chromatography and enzymatic determination. After alkaline hydrolysis the substance was converted to glutamic acid. Serum amino acid concentrations were normal. The patient had normal serum and erythrocyte folate levels. The red blood cell picture was normal. The leukocytes showed slight hypersegmentation. From the age of 3 months he exhibited recurrent otitis media and severe pulmonary infections. He had a peculiar narrow-headed look and marked universal hypotonia. The mental development was slightly retarded. Glutamate formiminotransferase deficiency is postulated. The findings lend support to the theory of glutamate formiminotransferase deficiency being a rather benign disorder of metabolism.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of inherited metabolic disease 7 (1984), S. 49-52 
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a mentally retarded boy, who excreted elevated amounts of glycine,d-glyceric acid and acylglycines and whose cells exhibited diminishedd-glycerate dehydrogenase and glycine cleavage activity, investigations have been undertaken aiming at characterizing the relationship betwnen the different accumulations. This was donein vivo by trying in a specific manner to alter in turn the degree of accumulation of each of the three classes of compounds and then monitoring changes in the others. The results suggest, that thed-glyceric acid accumulation is directly caused by the genetic defect, since thed-glyceric acid excretion was not altered by changes in degree of accumulation of either glycine or acylglycines. Similarly alterations in acylglycine excretion caused alterations in glycine but not ind-glyceric acid excretion. Based on these findings a model for the pathogenesis behind the accumulations of acylglycines and glycine is proposed.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 1-year-old boy with a typical B12-responsive form of methylmalonic acidaemia was hospitalized twice due to acute bacterial infections. On both occasions, the child was lethargic with a severe ketoacidosis on admission. Intensive therapy with protein restriction, intravenous administration of electrolytes and antibiotics was effective within 4 days on both occasions. The urinary excretion of organic acids showed the same pattern on both occasions. There were rising excretion concentrations, reaching a peak value within the first 24-hour period, for the following compounds: 3-hydroxybutyric acid, 3-hydroxypropionic acid, 3-hydroxyisobutyric acid and 3-hydroxyisovaleric acid. Excretion concentrations of the following rose for 48 h: isobutyric acid, 2-methylbutyric acid, isovaleric acid, lactic acid and the 2-oxo-acids. There was no increase until 12–24 h after the onset of severe illness in the excretion of propionic acid and methylmalonic acid. Propionic acid excretion was maximal at about 48 h, while peak excretion of methylmalonic acid was delayed until about 72 h after the onset of severe illness; at this time there was clinical improvement. The biochemical implications of this excretion pattern are discussed.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of inherited metabolic disease 3 (1980), S. 73-75 
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Argininosuccinate synthetase activity in amniotic fluid cells from a fetus at risk for citrullinaemia was low compared to the activity in amniotic fluid cells from a normal fetus, but five times the activity in fibroblasts from a patient with citrullinaemia. These enzyme values indicated a normal or heterozygous fetus. Chromosome analysis of the amniotic fluid cells from the fetus at risk, however, showed an unusual X/20 translocation. As we could not guarantee the delivery of a normal child, the parents chose to have a therapeutic abortion. Argininosuccinate synthetase activity in the liver and kidney of the aborted fetus was in the normal and heterozygous range respectively, confirming the prenatal diagnosis. The activity in the father's fibroblasts was low, less than 10% of normal. The difficulty of interpreting the results of prenatal diagnosis in such a family and the importance of studying parental cells are discussed.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Pharmacy world & science 3 (1981), S. 1163-1165 
    ISSN: 1573-739X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 4 (1931), S. 470-502 
    ISSN: 1439-6327
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 4 (1931), S. 128-153 
    ISSN: 1439-6327
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Es wurden Blutzuckerbestimmungen während und nach der Arbeit an einer weiblichen und zwei männlichen Vpn. ausgeführt. Eine gründliche Analyse der vorliegenden Literatur zeigt, daβ bis jetzt überhaupt keine einwandfreien Blutzuckerbestimmungen während körperlicher Arbeit ausgeführt worden sind. Es wird auf Grund eigener Versuche gezeigt, daβ nur die Werte, die während unveränderter Arbeit gewonnen worden sind, Arbeitswerte genannt werden dürfen; wird die Arbeit auch nur für weniger als eine Minute unterbrochen, sind die erhaltenen Werte keine, Arbeits-, sondern Restitutionswerte. Die erhaltenen Werte zeigen große individuelle Schwankungen von Versuch zu Versuch, aber alle Kurven zeigen doch, daß in der Regel der Blutzucker zu Beginn der Arbeit unter den Ruhewert abfällt und mit dem Aufhören der Arbeit, oder schon früher, wieder ansteigt. Es scheint kein Zusammenhang zwischen Blutzucker, Arbeitsintensität und Ermüdungsgrad zu bestehen. Bei langdauernder großer Arbeit kann man eine auch in der Restitutionsphase anhaltende Senkung des Blutzuckerspiegels hervorrufen. Diese Senkung wird auf einen verminderten Glykogengehalt zurückgeführt. Es wird mit Hilfe der Versuchsresultate gezeigt, daß die Mehrzahl der bis jetzt aufgestellten Theorien zur Erklärung der Blutzuckerregulation während körperlicher Arbeit von falschen Voraussetzungen ausgehend, nicht stichhaltig sind. Es werden einige der Faktoren, die wahrscheinlich für die Höhe des Blutzuckerspiegels mitverantwortlich sind, hervorgehoben.
    Type of Medium: Electronic Resource
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