Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Effects of prenalterol on cardiac performance and transmural myocardial perfusion in patients with chronic renal failure (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 287-292 
    Details
    ISSN: 1432-1041
    Keywords: prenalterol ; chronic renal failure ; metoprolol ; blood pressure ; cardiac index ; stroke volume index ; transmural myocardial perfusion ; left ventricular ejection fraction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The acute haemodynamic effects of the beta-adrenoreceptor agonist, prenalterol, were studied in six patients with chronic end-stage renal failure. Prenalterol 0.8 mg, 1.6 mg, and 3.2 mg was administered i.v. as a bolus, and after the last dose the selective adrenergic beta-1-receptor antagonist metoprolol was administered i.v. in doses of 5 and 10 mg. The haemodynamic effects of the drugs were investigated using impedance cardiography and radionuclide angiocardiography. The main haemodynamic effects were a dose-related chronotropic effect, demonstrated by an increase in heart rate (26%; 〈0.05), and an inotropic effect, shown by an increase in stroke volume index (20%;p〈0.05) and left ventricular ejection time (12%;p〈0.05); the cardiac index was increased by 47% (p〈0.05). Transmural myocardial perfusion (DPTI/SPTI ratio) was decreased by 22% (p〈0.05) after prenalterol. It is concluded that prenalterol has positive inotropic and chronotropic effects in patients with chronic renal failure, that the improvement in left ventricular performance is at the expense of a decreased transmural myocardial perfusion, and that metoprolol is a specific antidote.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01037935
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Supernovae and nitrate in the Greenland Ice Sheet (1981)
    [s.l.] : Nature Publishing Group
    Nature 294 (1981), S. 637-639 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Nitrate deposited in the Antarctic Ice Sheet has attracted attention because of its possible production by the absorption of ionizing radiation from extraterrestrial sources in the stratosphere1"3. The deposition rate of nitrate in snow accumulated in areas remote from soil and sea should then ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/294637a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Prazosin treatment of primary Raynaud's phenomenon (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 421-423 
    Details
    ISSN: 1432-1041
    Keywords: prazosin ; Raynaud's phenomenon ; alpha-blockade ; provocation test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a double blind study, prazosin, a specific adrenergic alpha1-receptor antagonist, or placebo were given to 15 females with primary Raynaud's phenomenon. At a low dose (1 mg twice daily) 5 out of 7 of the prazosin-treated patients reported a reduction of attacks induced by cold (p〈0.05). This was not confirmed by a cold provocation test which showed no improvement at finger temperatures of 15 or 10°C. The highest tolerated dose in the prazosin-treated patients varied from 2–8 mg daily, and the greatest number of side effects was recorded in this group (p〈0.05). None of the patients experienced complete relief from cold-induced attacks. It was concluded either that Raynaud's phenomenon is not only caused by stimulation of alpha1-receptors in digital arteries, or the clinically achievable blockade was insufficient to prevent attacks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00610065
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Equation of state for monomolecular films of melittin at air-water interface (1983)
    Springer
    Colloid & polymer science 261 (1983), S. 767-775 
    Details
    ISSN: 1435-1536
    Keywords: monomolecular films ; melittin ; air-water-interface
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The spread monolayers of proteins at the air-water interface have been reported to be very useful model membrane systems. The charged protein monolayers have been analyzed by using the Gouy-Chapman (-Stern) models. These models gave satisfactory analyses of “non-membrane” proteins, but could not be used for the data of charged melittin monolayers (“membrane protein”). In order to describe these data, a new discrete (net) charge model is developed, and the equation of state for these two-dimensional films is discussed herein. This study shows, for the first time, that discrete (net) charges are present in charged melittin (a peptide with 26 amino acids) monolyers. The measured surface pressure,Π, and surface potential,Δψ, are analyzed with the help of the discrete charge model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01410951
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Biochemical studies in a patient with defects in the metabolism of acyl-CoA and sarcosine: Another possible case of glutaric aciduria type II (1980)
    Springer
    Journal of inherited metabolic disease 3 (1980), S. 67-72 
    Details
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The clinical and biochemical abnormalities in a neonate, who died in coma accompanied by severe hypoglycaemia at the age of 3 days, are described. The study of the urinary metabolic profiles of organic acids and amino acids revealed that the excretion rates of glutaric acid, isovaleric acid, isovalerylglycine, 3-hydroxyisovaleric acid and isobutyric acid were very high. Increased excretion rates were also found for 2-methylbutyric acid, adipic acid, caproylglycine, 5-hydroxycaproic acid, caproic acid and butyric acid. The amino acid, sarcosine, was excreted in enhanced amounts and the patient had lactic aciduria, whereas the excretion of 3-hydroxybutyric acid was only moderately increased. This abnormal excretion pattern is consistent with a defect in the metabolism of acyl-CoAs and sarcosine. Normal activity of glutaryl-CoA dehydrogenase was found, excluding glutaryl-CoA dehydrogenase deficiency (glutaric aciduria type I).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02312527
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Excretion pattern of branched-chain amino acid metabolites during the course of acute infections in a patient with methylmalonic acidaemia (1980)
    Springer
    Journal of inherited metabolic disease 3 (1980), S. 63-66 
    Details
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 1-year-old boy with a typical B12-responsive form of methylmalonic acidaemia was hospitalized twice due to acute bacterial infections. On both occasions, the child was lethargic with a severe ketoacidosis on admission. Intensive therapy with protein restriction, intravenous administration of electrolytes and antibiotics was effective within 4 days on both occasions. The urinary excretion of organic acids showed the same pattern on both occasions. There were rising excretion concentrations, reaching a peak value within the first 24-hour period, for the following compounds: 3-hydroxybutyric acid, 3-hydroxypropionic acid, 3-hydroxyisobutyric acid and 3-hydroxyisovaleric acid. Excretion concentrations of the following rose for 48 h: isobutyric acid, 2-methylbutyric acid, isovaleric acid, lactic acid and the 2-oxo-acids. There was no increase until 12–24 h after the onset of severe illness in the excretion of propionic acid and methylmalonic acid. Propionic acid excretion was maximal at about 48 h, while peak excretion of methylmalonic acid was delayed until about 72 h after the onset of severe illness; at this time there was clinical improvement. The biochemical implications of this excretion pattern are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02312526
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Theβ-oxidation of dicarboxylic acids in isolated mitochondria and peroxisomes (1983)
    Springer
    Journal of inherited metabolic disease 6 (1983), S. 123-124 
    Details
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01810358
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...