ISSN:
1432-1912
Keywords:
C6 Glial cells
;
6-Aminonicotinamide
;
Glycolysis
;
Glycogen
;
Morphological alteration
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary 1. 6-Aminonicotinamide (0.01 mg/ml) leads to a strong accumulation of 6-PG in C6 glial cells after 24 h. 2. The accumulated 6-PG is dephosphorylated to gluconate which easily permeates the cell membrane. Extracellular gluconate is formed at a rate of 12% of the total glucose consumption. 3. 6-PG as competitive inhibitor of the PGI caused a reduction of the glycolytic flux of about 40%. 4. The reduced glycolytic flux lowers the ATP concentration under anaerobic conditions to 75% of the controls. 5. The glycogen content after 6-AN is increased by 50%, probably by the activation of the glycogen synthetase due to the higher Glc 6-P concentration. 6. The fibroblast-like morphology of the C6 cell line has typically changed under 6-aminonicotinamide.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00507857
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