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  • Electronic Resource  (39)
  • 1970-1974  (14)
  • 1965-1969  (21)
  • 1955-1959  (2)
  • 1900-1904  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Vinylidene Cyanide. VII. Copolymerization1a (1956)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 78 (1956), S. 1669-1675 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01589a049
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Iodinated 5- and 8-Hydroxyisoquinolines as Potential Amebicides (1966)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 9 (1966), S. 46-48 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00319a011
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Dorsal Root Potentials evoked by Natural Stimulation of Cutaneous Afferents (1966)
    [s.l.] : Nature Publishing Group
    Nature 212 (1966), S. 522-523 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The central organization and the functional significance of the powerful presynaptic inhibition of cutaneous afferent fibres2 cannot be examined in detail by using electrical stimulation of peripheral nerves, since neither is there a correlation between the nerve fibre threshold and the various ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/212522a0
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  • 4
    Electronic Resource
    Electronic Resource
    Inhibition of DNA synthesis by lidocaine and procaine (1971)
    Springer
    Cellular and molecular life sciences 27 (1971), S. 261-262 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Nachweis, dass in Ehrlich-Ascites-Zellen die DNS-Synthese durch Lokalanaesthetika stärker gehemmt wird als die RNS- und die Proteinsynthese.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02138133
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  • 5
    Electronic Resource
    Electronic Resource
    Röntgenbestrahlung und Hypothermie. Der Einfluss auf Körpergewicht, Hirngewicht, Kleinhirnentwicklung und Blutbild bei neugeborenen Hausmäusen (1969)
    Springer
    Cellular and molecular life sciences 25 (1969), S. 476-476 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary New-born mice were X-rayed under extreme hypothermia in order to estimate the radioprotective effect of hypothermia on body weight, brain weight, development of cerebellum and the hematopoietic system. A protective effect was found in the rate of survival, in body and brain weight, in the cerebellum and in the number of erythrocytes. After hypothermia, the repair of damage in the cerebellum and the erythropoietic system starts earlier. The protected mature cerebellum shows an approximately normal status. Hypothermia does not prevent the initial decrease of lymphocytes caused by X-rays, and it produces a severe disturbance of hemoglobin content.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01900763
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  • 6
    Electronic Resource
    Electronic Resource
    Excitability measurements at the central terminals of single mechano-receptor afferents during slow potential changes (1967)
    Springer
    Experimental brain research 3 (1967), S. 220-233 
    Details
    ISSN: 1432-1106
    Keywords: Mechanoreceptors ; Cutaneous Afferents ; Afterpotentials ; Primary Afferent Depolarization ; Spinal Cord
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mechanoreceptors of the hairy skin and the central pad of the cat's hind foot were activated using piezo-electric crystals as mechanical stimulators. Their afferent fibres were traced in the lumbar spinal cord by stimulating antidromically and by recording the collision of the antidromic and orthodromic action potentials. Low threshold mechanoreceptor units could be stimulated in isolation. It was possible, therefore, to follow the postspike excitability changes of their fibres in the spinal cord without interference from other spinal cord potentials. Primary afferent depolarization has been induced in cutaneous afferents by stimulating muscle and cutaneous nerves. It has been found that the a cutaneous fibres of mechanoreceptors were depolarized by volleys in a cutaneous fibres and to a lesser degree by volleys in Group I b, II and III muscle afferents but not by high threshold cutaneous afferents. The primary afferent depolarization of cutaneous fibres has been subjected to the action of an impulse propagating down that fibre to its central terminals. Excitability testing revealed that the amplitude and the time course of the primary afferent depolarization were only altered up to about 30 ms after the impulse indicating an active depolarization of the presynaptic terminals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235586
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  • 7
    Electronic Resource
    Electronic Resource
    Transport, verteilung und Metabolismus von3H-und14C-markiertem DDT in graviden mäusen unter hungerbelastung (1972)
    Springer
    Cellular and molecular life sciences 28 (1972), S. 56-57 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary After i.p. application of 1, 0,5 and 0,1 mg p,p' DDT, labelled with3H or14C, to pregnant mice in different stages of pregnancy, the same level of radioactivity was found in the fetal and maternal blood. Starvation for 2 days caused a significant increase of residues, especially in the liver. Residue levels of DDT and its metabolities DDE, DDD, DCB and (DDOH+DDA) are found in fetal and maternal blood, brain liver and fat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01928263
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  • 8
    Electronic Resource
    Electronic Resource
    Single unit responses and the total afferent outflow from the cat's foot pad upon mechanical stimulation (1968)
    Springer
    Experimental brain research 6 (1968), S. 100-115 
    Details
    ISSN: 1432-1106
    Keywords: Mechanoreceptors ; Pacinian corpuscles ; Cutaneous afferents ; Peripheral encoding ; Skin sensitivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The properties of mechanosensitive units with large myelinated afferents were determined in the hairless skin of the central pad of the cat's hind foot, and the total afferent outflow from this region after short skin indentations and during constant force stimuli was measured in the plantar nerves. Basically three types of mechanosensitive units with afferent conduction velocities above 40 m/s were found: (a) receptors with the properties of Pacinian corpuscles (PC-receptors); (b) receptors which showed burst discharges for up to 500 ms after the onset of a constant force stimulus (RA-receptors); and (c) receptors which discharged throughout a constant force stimulus (SA-receptors). The afferent conduction velocities of these units were in the same range as those of receptors from the surrounding hairy skin. A considerable proportion of receptors from both skin areas had no collaterals in the dorsal columns. The afferent outflow after short skin indentations of up to 5 μ displacement consisted of impulses from PC-receptors only. Stimuli of 20 μ recruited between 50 and 100 afferent units of which less than 10% were other than PC-units. During constant force stimuli the afferent outflow came from SA-receptors only. Ten seconds after stimulus onset a 500 g stimulus evoked an afferent discharge of about 1000 imp/s and a 1000 g stimulus of about 1700 imp/s. At all times a power function of the form F=K · (S−S0)n related the afferent discharge F to the stimulus intensity S. The exponents were around n=0.5 and tended to increase in the course of the stimulus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00239165
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  • 9
    Electronic Resource
    Electronic Resource
    Two specific feedback pathways to the central afferent terminals of phasic and tonic mechanoreceptors (1968)
    Springer
    Experimental brain research 6 (1968), S. 116-129 
    Details
    ISSN: 1432-1106
    Keywords: Cutaneous afferents ; Primary afferent depolarization ; Presynaptic inhibition ; Surround inhibition ; Spinal cord
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In five types of mechanoreceptor afferents of the cat's hind foot, the primary afferent depolarization (PAD) induced by mechanical skin stimulation was measured by testing the excitability of their terminations in the dorsal horn. Two types of skin stimuli were used to set up activity in distinct populations of rapidly and slowly adapting mechanoreceptors respectively. The experiments revealed that two systems exist to generate PAD in cutaneous afferents, both being of negative feedback character. One system is activated by impulses from rapidly adapting low threshold receptors and preferentially depolarizes the terminals of such afferents, and correspondingly, the other system is activated by and operates on the slowly adapting units. In both PAD systems the size of the depolarization is graded depending on the stimulus strength. Further, the “tonic” system displays a “surround” pattern of organization similar to that of the “phasic” system which has already been described (Schmidt et al. 1967b). In the discussion the operational relationships of both systems and their functional implications are outlined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00239166
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  • 10
    Electronic Resource
    Electronic Resource
    Cutaneous mechanoreceptors influencing impulse discharges in cerebellar cortex. I. In mossy fibers (1972)
    Springer
    Experimental brain research 15 (1972), S. 245-260 
    Details
    ISSN: 1432-1106
    Keywords: Cerebellum ; Cutaneous mechanoreceptors ; Mossy fibers ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This paper gives an account of single mossy fiber responses when three types of mechanical stimulation are applied to the forefoot and hindfoot of the cat which is either decerebrate and unanesthetized or lightly anesthetized by pentothal or chloralose. The mechanical stimuli were applied either to footpads (brief pulses, taps, or longer square pulses or ramps) or to the hairy skin by air jets. Recording of single mossy fibers was extracellular by glass microelectrodes that were inserted into the granular layer of the cerebellar cortex or the subjacent white matter. As described in previous papers computer averaging techniques usually of 64 responses have been employed to enhance reliability. Taps evoked pure excitatory responses from many mossy fibers, which were usually brief high frequency bursts resembling those evoked by nerve volleys. Usually the threshold displacement was less than 0.2 mm and thresholds as low as 0.01 mm were observed. There were often considerable differences in the intensities of responses from different pads of the same foot. Successive pulses of mechanical stimulation evoked mossy fiber responses of diminished intensity. Longer mechanical stimuli with square or ramp onsets evoked various admixtures of phasic and tonic responses. Hair stimulation was often a very effective excitant, the receptive field for a single mossy fiber usually covering a considerable area of foot and leg. Taps and pressure to the pads were also effective in inhibiting the background discharge of some mossy fibers, and admixtures of excitatory and inhibitory actions were observed. The results are discussed in relationship to the discharges evoked in primary afferent fibers by cutaneous mechanoreceptor stimulation. They provide an intermediate stage of information between mechanoreceptor stimulation and the response of Purkyně cells as described in the next paper.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235910
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