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  • Electronic Resource  (4)
  • 1970-1974  (4)
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  • Electronic Resource  (4)
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  • 1
    Electronic Resource
    Electronic Resource
    Conferences in Russia? (1973)
    [s.l.] : Nature Publishing Group
    Nature 245 (1973), S. 343-343 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR,?Two events occurred this summer which, taken together, should be of particular concern to geneticists, as well as many other scientists. On July 16 the Supreme Soviet deprived Dr Zhores Medvedev of his Soviet citizenship, thus preventing his return from Britain to the USSR. On August 23 it was ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/245343a0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Senescence of Human Cells in Culture (1973)
    [s.l.] : Nature Publishing Group
    Nature 242 (1973), S. 332-332 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/242332a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Ageing of human fibroblasts in culture: Studies on enzymes and mutation (1972)
    Springer
    Human genetics 〈Berlin〉 16 (1972), S. 83-86 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00393991
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Genetic repair and the synthesis of nitrate reductase in Ustilago maydis after UV irradiation (1971)
    Springer
    Molecular genetics and genomics 111 (1971), S. 171-184 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The ability of UV-sensitive (uvs -) and wild type (uvs +) strains of Ustilago maydis to synthesize the inducible enzyme nitrate reductase (NR) was examined following UV-exposure. Low doses of UV-irradiation prior to induction inhibit to a greater degree the first appearance of NR in uvs - as compared to uvs + strains; in addition, the exponentially increasing rates of NR synthesis are much less in the uvs - strains. It is concluded that the damage is primarily pyrimidine dimers in the DNA, since the UV-induced effects are largely removed by photoreactivation. At all but the lowest dose, at least one dimer on the average appears to be induced per functional strand of the nitrate reductase gene. If cells are irradiated after being suspended in NR inducing medium. enzyme synthesis is temporarily stopped or considerably reduced indicating that the mRNA has a short half-life and that transcription is inhibited. However, it resumes within 20 min after exposure which suggests that alteration or removal of damage is very rapid. Unrepaired or improperly repaired dimer regions lead to the production of altered enzyme as shown by the presence of enzyme cross reacting material and the heat lability of NR in crude cell extracts. It is proposed that the synthesis of altered enzyme may be due in part to transcription past unrepaired or improperly repaired dimer regions in the nitrate reductase gene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00267791
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    Paper (German National Licenses)
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