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  • Electronic Resource  (6)
  • Emergency endoscopy  (3)
  • Anxiety  (2)
  • (Rat)  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Investigation of the active center of rat pancreatic elastase
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular 994 (1989), S. 64-74 
    Details
    ISSN: 0167-4838
    Keywords: (Pig) ; (Rat) ; Elastase inhibitor ; Elastase substrate ; Pancreatic elastase ; Substrate activation ; Substrate inhibition
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0167-4838(89)90063-0
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  • 2
    Electronic Resource
    Electronic Resource
    Sex differences in nicotine substitution to a pentylenetetrazol discriminative stimulus during ethanol withdrawal in rats (2000)
    Springer
    Psychopharmacology 149 (2000), S. 235-240 
    Details
    ISSN: 1432-2072
    Keywords: Key words Sex differences ; Nicotine ; Pentylenetetrazol ; Discriminative stimulus ; Ethanol withdrawal ; Anxiety
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Rationale: Nicotine and ethanol are frequently co-abused in men and women, but few studies compare common stimulus effects produced by these substances between males and females. Objectives: This study compared the anxiety-like behavior induced by nicotine prior to and during ethanol withdrawal in intact male, sham-operated female, and ovariectomized (OVX) rats. Methods: Using an animal model of anxiety, the pentylenetetrazol (PTZ) drug-discrimination assay, rats were trained to discriminate PTZ (16 mg/kg, i.p.) from saline and were subjected to the following tests: (1) PTZ-lever selection at 12 h after termination of ethanol diet (4.5% for 10 days); (2) dose–response tests for nicotine (0.08– 1.3 mg/kg) prior to ethanol and 1.5, 6, and 7 days after ethanol withdrawal. Results: (1) During acute ethanol withdrawal (12 h), more male rats (43.4%) responded on the PTZ lever than OVX (29%) or sham female (15.3%) rats. (2) For nicotine dose–response tests, more male rats (70%) selected the PTZ lever than OVX (37.5%) or sham female (50%) rats prior to ethanol. At 1.5 days, nicotine fully generalized to the PTZ stimulus in male (100%) and OVX (90%), but only partially in sham female (50%) rats. At 6 days and 7 days after ethanol withdrawal, the PTZ-lever selection decreased, but more male rats (78%) tended to respond on a PTZ lever than OVX (63.6%) or sham female rats (62.5%). Conclusions: Acute nicotine produces anxiety-like behavior similar to that of PTZ in male and female rats, and this effect of nicotine is intensified during ethanol withdrawal in male and OVX rats, but not in sham female rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130000392
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Sex differences in the discriminative stimulus effects of m-chlorophenylpiperazine and ethanol withdrawal (2000)
    Springer
    Psychopharmacology 149 (2000), S. 170-175 
    Details
    ISSN: 1432-2072
    Keywords: Key words  m-Chlorophenylpiperazine ; Drug discrimination ; Ethanol withdrawal ; Anxiety ; 17β-estradiol ; Sex difference ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Rationale: The serotonergic system plays a role in regulation of anxiety and ethanol withdrawal (EW). Nevertheless, few studies have assessed sex differences in serotonergic effects on EW. Objectives: This study examined sex differences in the anxiogenic stimu-li induced by a serotonin (5-HT)1b/2 agonist, meta- chlorophenylpiperazine (mCPP), prior to ethanol and during EW. Methods: Gonadectomized or sham-operated adult male and female rats and 17β-estradiol (2.5 mg, 21-day release, s.c.) -replaced ovariectomized (OVX) rats were trained to discriminate mCPP (1.2 mg/kg, i.p.) from saline in a two-lever choice task for food. Latency to the first lever press and mCPP lever selection were measured following mCPP (0–1.2 mg/kg). Rats then received chronic ethanol-containing liquid diet (6.5%) for 10 days and were tested for mCPP lever selection 12 h and 36 h after removal of ethanol. Results: Fewer sham female and β-estradiol-replaced OVX rats selected the mCPP lever than male or OVX rats, and showed an increased initiation latency after mCPP injection. During EW (12 h and 36 h), fewer sham female and β-estradiol-replaced OVX rats responded on the mCPP-lever after saline injection as well as after mCPP challenge than male or OVX rats. Castration did not alter any response of male rats to mCPP. Conclusions: (1) mCPP discrimination is a useful measure of EW in male and female rats; and (2) sham female and β-estradiol-replaced OVX rats are less sensitive to the discriminative stimulus prior to and during EW, but more sensitive to impaired behavioral initiation induced by mCPP than male or OVX rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002139900353
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  • 4
    Electronic Resource
    Electronic Resource
    332. Das blutende gastroduodenal-Uleus — herausforderung für endoskopie und chirurgie (1987)
    Springer
    Langenbeck's archives of surgery 372 (1987), S. 943-944 
    Details
    ISSN: 1435-2451
    Keywords: Bleeding peptic ulcer ; Recurrent hemorrhage ; Emergency endoscopy ; Ulcusblutung ; Rezidivblutung ; Notfallendoskopie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Durch ein aggressiveres endoskopisch-chirurgisches Therapieschema (endoskopische Blutstillung unabhängig vom Forrest-Stadium, F Ia: Auch nach erfolgreicher Unterspritzung OP innerhalb 6 h, F Ib, II: Kontroll-Endoskopie und evtl. nochmalige Unterspritzung) konnten die Ergebnisse -signifikant verbessert werden: Senkung der Re-Blutungsrate von 35% auf 16% (P〈0,05), der Notfall-OP-Rate wegen Re-Blutung von 66% auf 28% (P 〈 0,05), Senkung der Letalität von 14,3% auf 6,3%.
    Notes: Summary Using a new therapeutic regimen for bleeding peptic ulcers, the results improved significantly: endoscopic hemostasis regardless of the Forrest stage, F I a: early operation within 6 h, even if the primary endoscopic hemostasis was successful; F I b, 11: second endoscopy within 24 h and repeat hemostasis, if necessary. The rate of rebleeding was reduced from 35% to 16% (sP〈 0.05), the rate of emergency operations due to rebleeding from 66% to 28% (P〈0.05), and mortality decreased from 14.3% to 6.3%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01298117
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  • 5
    Electronic Resource
    Electronic Resource
    371. Das blutende Gastroduodenalulcus — Enscheidungsfindung und Therapieplanung (1986)
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 869-870 
    Details
    ISSN: 1435-2451
    Keywords: Medical decision making ; Bleeding peptic ulcer ; Recurrent haemorrhage ; Emergency endoscopy ; Entscheidungsfindung ; Ulcusblutung ; Rezidivblutung ; Notfallendoskopie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das Hauptproblem in der Therapie des blutenden Ulcus ist die Rezidiv-Blutung nach konservativer oder endoskopischer Blutstillung. Die dann erforderliche Not-OP hat eine hohe Letalität (16%) gegenüber der elektiven OP (7%). Neue Therapie-Richtlinien: Endoskopische Blutstillung in jedem Blutungsstadium. Forrest la: Frühoperation. Forrest I b, II: Kontrollendoskopie nach 24 h. Die wiederholte endoskopische Kontrolle und Blutstillung führt vermehrt zu einer elektiven und selektiven Chirurgie mit einer Abnahme der postoperativen Komplikationen.
    Notes: Summary The main problem in therapy of bleeding peptic ulcer is recurrent haemorrhage after conservative or endoscopic haemostasis. Mortality of emergency operations due to rebleeding was more than twice as high (16%) as mortality of elective operations (7%). New regimen: Endoscopic haemostasis regardless of Forrest stage. Forrest I a: Early operation. Forrest I b, 11: Second endoscopy after 24 h. Repeated endoscopic treatment leads to more elective and selective surgery with decrease of postoperative complications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01274691
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  • 6
    Electronic Resource
    Electronic Resource
    171. Notfallendoskopie beim akuten Abdomen (1984)
    Springer
    Langenbeck's archives of surgery 364 (1984), S. 494-494 
    Details
    ISSN: 1435-2451
    Keywords: Acute abdominal disease ; Emergency endoscopy ; Perforated peptic ulcer ; Pseudo-obstruction of the colon ; Akutes Abdomen ; Notfallendoskopie ; Gedeckte Ulcusperforation ; Pseudoobstruktion des Colons
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das akute Abdomen ist eine chirurgische Erkrankung, die durch Anamnese, Inspektion, Palpation, Auskultation beurteilt wird. Im besonderen Fall unter besonderen Umständen bedarf es der Endoskopie. Beim Verdacht auf Ulcusperforation wird inspiziert. Der differentialdiagnostische Gewinn exakter Befundlokalisation ist größer als das Risiko der Eröffnung einer gedeckten Perforation. Die akute biliäre Pankreatitis, die tumor- oder steinbedingte septiforme Cholangitis wird durch ERCP, Sphincterotomie, Steinextraktion bzw. transpapilläre Ablaufsonde endoskopisch beherrscht. Die Pseudoobstruktion des Colons wird durch transanal ins Colon transversum eingeführte Dekompressionssonde erfolgreich beseitigt.
    Notes: Summary An acute abdominal disorder is a surgical disease, diagnosed by anamnesis, inspection, palpation and auscultation. In a special case and under special circumstances endoscopy is necessary. When we suspect perforation of a peptic ulcer, we perform endoscopy. The advantage of exact differential diagnosis is greater than the risk of opening a covered perforation. Acute biliary pancreatitis and tumorous or concremental septiform cholangitis should be controlled endoscopically by ERCP, sphincterotomy, stone extraction or biliary drainage, respectively. Pseudo-obstruction of the colon will be relieved by the insertion of decompressing tubes into the transverse colon per anum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01823344
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