ISSN:
0935-6304
Keywords:
Enantioselective gas chromatography
;
Heptakis (2,3-di-O-acetyl-6-O-tert-butyldimethylsilyl)-β-cyclodextrin
;
Polysiloxanes
;
Thermodynamic parameters
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The influence of different polysiloxane solvents on the efficiency and stereoselectivity of columns coated with mixtures of heptakis (2,3-di-O-acetyl-6-O-tert-butyldimethylsilyl)-β-cyclodextrin and the polysiloxanes was investigated. Generally, the enantioselectivity increased with decreasing polarity of the silicone solvent and/or increasing cyclodextrin concentration, with some exceptions. Thermodynamic investigations showed that a change of the diluting phase or the cyclodextrin concentration affects entropy as well as enthalpy differences between the diastereomeric cyclodextrin/solute complexes. As a consequence, a certain cyclodextrin/polysiloxane combination is superior to another only at a particular temperature.
Additional Material:
12 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jhrc.1240180303
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