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  • Electronic Resource  (2)
  • 2-aminoethyl disulfide  (1)
  • Current-voltage analysis  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Comparative platelet anti-aggregant activity of D-cysteinolic acid analogues (1989)
    Springer
    Cellular and molecular life sciences 45 (1989), S. 1110-1112 
    Details
    ISSN: 1420-9071
    Keywords: D-Cysteinolic acid ; platelet aggregation ; inhibitor ; marine product ; 2-aminoethyl disulfide ; sardine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary D-Cysteinolic acid (1) analogues with an S-C-C-N skeleton showed increased platelet anti-aggregant activity in the following order: 2-aminoethanesulfonic acids, thiazolidines, 2-aminoethanethiols and 2-aminoethyl disulfides. Methyl substitutions at the 2-position potentiated the activity. Of these analogues, bis [(R)-2-aminopropyl] disulfide was the most potent inhibitor of platelet aggregation, with about 600-fold the activity of (1).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01950172
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The proton pump, high pH channels, and excitation: voltage clamp studies of intact and perfused cells ofNitellopsis obtusa (1993)
    Springer
    Protoplasma 175 (1993), S. 144-152 
    Details
    ISSN: 1615-6102
    Keywords: Current-voltage analysis ; High pH state ; Intracellular perfusion ; Membrane excitation ; Nitellopsis obtusa ; Proton pump
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The current-voltage (I/V) and conductance-voltage (G/ V) characteristics were recorded for intact and perfused (tonoplast-free) cells ofNitellopsis obtusa. In the pH0 range 5 to 8, the I/V profile was sigmoidal and the G/V profile exhibited a maximum — these characteristics are attributed to the proton pump at the plasmalemma. The pH0 dependence in this range was very similar to that found inChara corallina. At very alkaline pH0 (11.0) the high conductance due to H+/OH− channels was observed in intact cells but not in perfused cells. Young plants ofNitellopsis did not display bands of calcification, but did exhibit pH banding patterns in petri dishes. The pH bands were less than 5mm wide. The excitation transients in intact cells featured two peaks near the excitation threshold, but more peaks could be observed in the p.d. (potential difference) range −90 to −60 mV. The amplitude of the transients was strongly inhibited at pH0 11.0. In the perfused cells the currents lacked complete inhibition at some p.d. levels, but still exhibited one or two peaks. At high pH0 this lack of inactivation was accentuated. The addition of 5 mM TEA to the outside medium abolished the excitation transients in perfused cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01385013
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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