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  • Electronic Resource  (5)
  • 34.50.Hc  (2)
  • receptor autoradiography  (2)
  • 3-acetylpyridine  (1)
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  • Electronic Resource  (5)
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  • 1
    Electronic Resource
    Electronic Resource
    Long-term effects of 3-acetylpyridine-induced destruction of cerebellar climbing fibers on Purkinje cell inhibition of vestibulospinal tract cells of the rat (1987)
    Springer
    Experimental brain research 66 (1987), S. 229-246 
    Details
    ISSN: 1432-1106
    Keywords: 3-acetylpyridine ; Climbing fiber ; Inferior olive ; Vestibulospinal tract ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The inhibitory action of Purkinje cells on vestibulospinal tract (VST) cells was examined in rats deprived of climbing fibers with 3-acetylpyridine (3-AP) intoxication. In order to resolve discrepancies raised in previous studies with various means, special efforts were devoted to directly estimate Purkinje cell inhibition at synaptic levels by using intracellular recording, to avoid sampling bias by using a systematic survey of VST cells in each rat, and to evaluate the time-dependence of the effects of climbing fiber deafferentation by regular testing at 10 day intervals until 160 days after 3-AP intoxication. As compared with 661 VST cells impaled in 15 control rats, 1771 VST neurons impaled in 29 3-AP-treated rats revealed four basic changes in the monosynaptic inhibitory postsynaptic potentials (IPSPs) induced by stimulation of Purkinje cell axons in the white matter of the cerebellar anterior lobe. First, the rate of IPSP occurrence among VST cells was 0.64 in control rats; at more than 10 days after 3-AP intoxication it decreased gradually, down to 0.37–0.38 at the 70th–81st days, and thereafter increased up to 0.53 by the 160th day. The rate of IPSP occurrence varied considerably between the rostral and caudal regions, and also between the dorsal and ventral divisions of the VST cell population, but its reduction after 3-AP intoxication occurred approximately in parallel in all divisions. Second, IPSPs evoked with standard 500 μA pulse stimuli were smaller in size on and after day 10. The reduction of IPSP size was by as much as 53% of control values at the 70th–101st days in the dorsal division, but no significant change occurred in the ventral division of the VST cell population. Third, the latency of the IPSPs was prolonged by about 0.25 ms on and after day 10. Analysis of the relationship between the IPSP latency and the dorsoventral location of VST cells in the medulla suggests that the major cause for the prolongation of IPSP latency is an increased synaptic delay at Purkinje cell axon terminals. Fourth, the cerebellar stimulation threshold for evoking IPSPs was almost always below 100 μA in control rats, but values of 100–250 μA were common after the 40th day. Thus, climbing fiber deafferentation exerts long-term influences on excitability of Purkinje cell axons, and on the connectivity and synaptic transmission from Purkinje cell axons to VST cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00243301
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Long-term observations in gerbil brain following transient cerebral ischemia: Autoradiographic and histological study (1993)
    Springer
    Metabolic brain disease 8 (1993), S. 181-195 
    Details
    ISSN: 1573-7365
    Keywords: transient ischemia ; dopamine D1 ; naloxone ; forskolin ; receptor autoradiography ; gerbil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated the long-term changes that occur in the gerbil brain following transient cerebral ischemia using histology and receptor autoradiography. Transient ischemia was induced for 3 and 10 min, and animals were allowed to survive for 8 months. A histological study showed that 3-min ischemia caused neuronal damage and mild atrophy only in the hippocampal CA1 sector, and that 10-min ischemia produced severe neuronal damage and marked shrinkage in the hippocampal CA1 and CA3 sectors. Furthermore, severe neuronal damage was seen in the striatum after 10-min ischemia. Autoradiography study revealed that 3-min ischemia caused a significant reduction in [3H] naloxone binding in the frontal cortex, striatum, dentate gyrus, and thalamus, whereas [3H]SCH 23390 and [3H] forskolin binding was not significantly altered in all regions, In contrast, 10-min ischemia produced marked alteration in these binding sites in the striatum, hippocampus, thalamus, and substantia nigra. The alteration was especially notable in the hippocampal region and substantia nigra. These results indicate that hippocampal damage after transient ischemia, compared with that in other regions, is not static, but particularly progressive. Furthermore, they demonstrate a reduction in adenylate cyclase system in the striatum and substantia nigra after transient ischemia. Moreover, our results suggest that long-term survival after ischemia may induce synaptic modification of neurotransmitter and adenylate cyclase system in the hippocampus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00996929
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  • 3
    Electronic Resource
    Electronic Resource
    Age-dependent changes in second messenger and rolipram receptor systems in the gerbil brain (1994)
    Springer
    Journal of neural transmission 97 (1994), S. 135-147 
    Details
    ISSN: 1435-1463
    Keywords: Aging ; second messenger ; rolipram ; gerbil ; phosphodiesterase ; receptor autoradiography ; neurotransmitter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Age-related alterations in binding sites of major second messengers and a selective adenosine 3′,5′-cyclic monophosphate (cyclic-AMP) phospho-diesterase (PDE) in the gerbil brain were analysed by receptor autoradiography. [3H]Phorbol 12,13-dibutyrate (PDBu), [3H]inositol 1,4,5-trisphosphate (IP3), [3H]forskolin, [3H]cyclic-AMP, and [3H]rolipram were used to label protein kinase C (PKC), IP3 receptor, adenylate cyclase, cyclic-AMP dependent protein kinase (PKA), and Ca2+/calmodulin-mdependent cyclic-AMP PDE, respectively. In middle-aged gerbils (16 months old), [3H]PDBu binding was significantly reduced in the hippocampal CA 1 sector, thalamus, substantia nigra, and cerebellum, compared with young animals (1 month old). [3H]IP3 binding revealed significant elevations in the nucleus accumbens, hippocampal CA 1 sector, dentate gyrus, and a significant reduction in cerebellum of middle-aged gerbils. [3H]Forskolin binding in middle-aged animals was significantly increased in the nucleus accumbens and hilus of dentate gyrus, but was diminished in the substantia nigra and cerebellum. On the other hand, in middle-aged animals, [3H]cyclic-AMP binding revealed a significant elevation only in the hippocampal CA3 sector, whereas [3H] rolipram binding showed a significant reduction in the thalamus and cerebellum. Thus, the age-related alteration in these binding sites showed different patterns among various brain regions in middle-aged gerbils indicating that the binding sites of PKC, IP3, and adenylate cyclase are more markedly affected by aging than those of PKA and cyclicAMP PDE and that the hippocampus and cerebellum are more susceptible to these aging processes than other brain regions. The findings suggest that in-tracellular signal transduction is affected at an early stage of senescence and this may lead to neurological deficits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01277949
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Measurement of impact parameter dependent probabilities and total cross sections for targetK-shell ionization by He+ ions (1987)
    Springer
    The European physical journal 4 (1987), S. 339-342 
    Details
    ISSN: 1434-6079
    Keywords: 34.50.Hc
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We have measured the impact parameter dependent K-shell ionization probabilitiesP K (b) of Ca, Cr and Cu from collisions with 4.04 MeV He+ ions by particle-K X ray coincidences. A dependence on the target thickness was investigated to study a possible influence of multiple collisions onP K (b). We measured the total cross section σ K forK vacancy production simultaneously withP K (b) and σ K agrees within 30% with the integratedP K (b). A comparison of theP K (b) and σ K with SCA calculations of Trautmann et al. using RHFS wavefunctions for united atom and separated atom states is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01384886
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  • 5
    Electronic Resource
    Electronic Resource
    Solid-gas effect inK-vacancy production in near symmetric slow heavy-ion-atom collisions (1992)
    Springer
    The European physical journal 22 (1992), S. 451-456 
    Details
    ISSN: 1434-6079
    Keywords: 34.50.Hc ; 32.80.Hd ; 32.80.Kf ; 32.30.Rj
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We have measured the target thickness dependence ofK-vacancy production probabilities and total cross sections for 40.6 MeV Ar ions hitting Ca and Cu targets. The probabilities were measured as a function of the scattering angle between 0.13° and 1.4° by means of aK x-ray-particle coincidence. By integrating the measured probabilities over the impact parameter a significantly lower total cross section was obtained than the directly measured value. The maximum seen in the impact parameter dependent probability varies with decreasing target thickness towards the results obtained with molecular and atomic gas targets. From these observations a multiple collisionL-vacancy process prior to 2pπ-2pσ rational coupling is concluded.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01426086
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    Paper (German National Licenses)
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