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  • Electronic Resource  (6)
  • 78.70.Bj  (2)
  • Key words Multiple myeloma  (2)
  • human monoclonal antibody  (2)
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  • Electronic Resource  (6)
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  • 1
    Electronic Resource
    Electronic Resource
    Defect study on electron irradiated GaAs by means of positron annihilation (1994)
    Springer
    Applied physics 58 (1994), S. 59-62 
    Details
    ISSN: 1432-0630
    Keywords: 78.70.Bj ; 72.80.Ey
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Measurements of the positron lifetime and Doppler-broadened annihilation-radiation have been performed in electron-irradiated GaAs. The positron lifetime at the irradiation induced defects was ∼0.250 ns at 300 K. The defect clustering stage was found to occur at around 520–620 K, and the coarsening and annealing stage is believed to be above 620 K. Similar annealing stages were also observed in GaAs lightly doped with Si (0.2×1018 cm−3). Both the lifetime and the S-parameter in the irradiated GaAs were found to decrease with temperature from 300 K to 100 K, suggesting the coexistence of shallow traps in electron irradiated GaAs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00331517
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  • 2
    Electronic Resource
    Electronic Resource
    Defect study of proton-irradiated liquid-encapsulated Czochralski GaAs using the positron-annihilation technique (1995)
    Springer
    Applied physics 60 (1995), S. 57-60 
    Details
    ISSN: 1432-0630
    Keywords: 78.70.Bj ; 72.80.Ey
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract The positron lifetime of undoped Liquid-Encapsulated Czochralski (LEC)-GaAs and Si-doped (1.3×1018 cm−3) LEC-GaAs was measured before and after irradiation with protons (dose 1×1015/cm2, 15 MeV). In Si-doped GaAs, the decrease of positron lifetime at temperatures between 10 and 300 K are due to the decrease of the positron-diffusion length and the increase of the effective shallow traps such as antisite GaAs. The annealing stage of the proton-irradiation-induced defects which show the different behavior from that of electron-irradiation-induced defects suggests that proton irradiation creates more complicated defect complexes, containing vacancies rather than isolated vacancy-type defects or simple complexes which have been observed during electron-irradiation processes. Above 700 K, proton-irradiation-induced defects such as vacancy-type defects and simple vacancy complexes are almost annealed out, while Si-induced defects such as SiGa-VGa complexes cannot be annealed out above 973 K.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01577613
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Prediction of prognosis by electron microscopic analysis of myeloma cells (1996)
    Springer
    Annals of hematology 73 (1996), S. 169-173 
    Details
    ISSN: 1432-0584
    Keywords: Key words Multiple myeloma ; Ultrastructure ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Myeloma cells were ultrastructurally analyzed in relation to survival in 54 patients with myeloma who were treated with melphalan-prednisolone or cyclophosphamide-prednisolone. Since previous studies by electron microscope had demonstrated that the degree of nuclear-cytoplasmic asynchrony of myeloma cells was associated with poor prognosis, this study focused on three kinds of nuclear abnormalities and eight kinds of cytoplasmic abnormalities. The patients were classified into three groups according to the presence of these abnormalities. The median survival times of the first group with five or fewer of 11 different kinds of abnormalities, the second group with 6–8 abnormalities, and the third group with nine or more abnormalities were 2353, 531, and 115 days, respectively. Furthermore, this classification by ultrastructural abnormalities corresponded to those by the initial hemoglobin concentrations, platelet counts, and percentages of myeloma cells and plasmablasts in the bone marrow. These findings suggest that ultrastructural analysis of nuclear and cytoplasmic abnormalities, in addition to nuclear maturity, of myeloma cells may provide important information for predicting the prognosis in myeloma patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050222
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  • 4
    Electronic Resource
    Electronic Resource
    Prognostic value of morphological classifications and clinical variables in elderly and young patients with multiple myeloma (1999)
    Springer
    Annals of hematology 78 (1999), S. 19-23 
    Details
    ISSN: 1432-0584
    Keywords: Key words Multiple myeloma ; Prognostic factor ; Morphology ; Elderly ; Young
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The prognostic value of morphological classifications and clinical variables was compared between 31 elderly (≥65 years) and 43 young (〈65 years) patients with myeloma. Prognostic factors were divided into three groups: factors useful in elderly patients, e.g., calcium, albumin; factors useful in young patients, e.g., platelet, creatinine, light-chain type; and factors useful in both patients, e.g., clinical stage, hemoglobin, LDH, CRP, bone marrow plasma cell and plasmablast percentages, light- and electron-microscopic classifications. The 5-year survival rates of elderly patients with calcium 〈12 and ≥12 mg/dl were 66.2 and 〈11.1%, respectively (p〈0.01). Those of the young patients were 64.1 and 33.3%, respectively. The 5-year survival rates of elderly patients with platelets ≥200×109/l and 〈100×109/l were 59.7 and 50.0%, respectively. Those of the young patients were 68.9 and 33.3%, respectively (p〈0.05). The 5-year survival rates of elderly patients with few and numerous electron-microscopic abnormalities were 90 and 0%, respectively (p〈0.01), those of young patients were 92.9 and 〈14.3%, respectively (p〈0.01). These findings suggest that individual clinical variables may differ in prognostic importance in elderly and young patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050466
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  • 5
    Electronic Resource
    Electronic Resource
    Stimulation of monoclonal antibody production by human-human hybridoma cells with an elevated concentration of potassium or sodium phosphate in serum-free medium (1989)
    Springer
    Cytotechnology 2 (1989), S. 63-67 
    Details
    ISSN: 1573-0778
    Keywords: human monoclonal antibody ; potassium phosphate ; sodium phosphate ; human-human hybridoma and serum-free medium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Potassium or sodium phosphate was found to stimulate the production of human monoclonal antibody by human-human hybridoma HB4C5. The addition of 15 mM Na-phosphate (pH 7.4) into serum-free culture medium increased the antibody production up to 4-fold, when seeded at cell density of 1×105 cells/ml in dishes. At the higher cell density of 5×105 cells/ml, K-phosphate was more effective than Na-phosphate, at the same concentration. In large-scale continuous culture, the addition of 10 mM Na-phosphate into serum-free culture medium stimulated antibody production by HB4C5 cells 6-fold.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00365416
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  • 6
    Electronic Resource
    Electronic Resource
    Serodiagnosis of cancer, using porcine antigens recognized by human monoclonal antibody, HB4C5 (1989)
    Springer
    Biotherapy 1 (1989), S. 109-115 
    Details
    ISSN: 1573-8280
    Keywords: serodiagnosis ; human monoclonal antibody ; human-human hybridoma ; porcine pancreas ; porcine antigen ; lung cancer and ovary cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Antigens, recognized by human monoclonal antibody (HB4C5) generated from a lung cancer patient, were found to occur in porcine pancreas. The antigens-I and -I1 were purified from crude trypsin of porcine pancreas, only by Mono Q column chromatography, and were eluted at 260 and 300 mM NaCl in 10 mM Tris-HCI buffer, pH 7.4, respectively. These antigens differed from trypsin in molecular weight, elution pattern from the Mono Q column, and their reactivity with HB4C5. The molecular weights of the two antigens were almost the same at around 35000. These were used for serodiagnosis with an assay system based on 96-well immunoplates. The reactivities of antigens-I and -II with various sera were similar. When the reactivity of IgG in serum with antigen-II was measured, absorbance at 415 nm in the case of normal and lung cancer patients was 0.178 ± 0.056 and 0.492 ± 0.136 (p 〈 0.005). The rates of positive reaction in ovary, larynx, uterus, lung and liver cancers were more than 50%, but the rates in stomach and breast cancers were less than 30%. Positive reaction was hardly detected in pancreas cancer and normal controls.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02170142
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