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  • Digitale Medien  (3)
  • benzodiazepine antagonist  (2)
  • Acute Leukenia  (1)
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  • Digitale Medien  (3)
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  • 1
    Digitale Medien
    Digitale Medien
    Pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 in man (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 115-117 
    Details
    ISSN: 1432-1041
    Schlagwort(e): benzodiazepine antagonist ; Ro 15-1788 ; healthy volunteers ; pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 has been studied in 6 healthy male volunteers following a single intravenous dose of 2.5 mg. The drug was only slightly bound to plasma proteins (40±8%, mean±SD). A negligible amount (〈0.2% of the dose) of unchanged drug was recovered in urine. Hepatic elimination was rapid, as shown by a short t1/2 of 0.9±0.2 h, and high total plasma and blood clearances of 691±216 ml/min and 716±199 ml/min, respectively. The fast decline of plasma levels from about 60 to 2 ng/ml accounts for the short-lasting reversal of benzodiazepine-induced sedation by Ro 15-1788.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00553165
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 in man (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 115-117 
    Details
    ISSN: 1432-1041
    Schlagwort(e): benzodiazepine antagonist ; Ro 15-1788 ; healthy volunteers ; pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 has been studied in 6 healthy male volunteers following a single intravenous dose of 2.5 mg. The drug was only slightly bound to plasma proteins (40±8%, mean±SD). A negligible amount (〈0.2% of the dose) of unchanged drug was recovered in urine. Hepatic elimination was rapid, as shown by a short t1/2 of 0.9±0.2 h, and high total plasma and blood clearances of 691±216 ml/min and 716±199 ml/min, respectively. The fast decline of plasma levels from about 60 to 2 ng/ml accounts for the short-lasting reversal of benzodiazepine-induced sedation by Ro 15-1788.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02395217
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
  • 3
    Digitale Medien
    Digitale Medien
    Knee arthritis revealing acute leukemia in a patient with rheumatoid arthritis (1991)
    Springer
    Clinical rheumatology 10 (1991), S. 76-77 
    Details
    ISSN: 1434-9949
    Schlagwort(e): Synovitis ; Acute Leukenia ; Leukemic Synovitis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We report one case of leukemic synovitis in a patient with a 40-year history of rheumatoid arthritis. The synovial fluid sample and synovial biopsy specimen showed myeloblastic cells. So, leukemic synovitis can be suspected in a patient with inflammatory rheumatism and adequate diagnostic procedures should be carried out.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02208036
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
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