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  • Electronic Resource  (5)
  • Airway Resistance  (3)
  • Chronic obstructive airway disease  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Lung 150 (1974), S. 83-96 
    ISSN: 1432-1750
    Keywords: Exposure to SO2 ; Airway Resistance ; Time-Concentration Curve ; Obstructive Bronchitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Anhand eigener Ergebnisse und anhand der Literaturangaben werden verschiedene Bereiche der SO2-Belastung von Tier und Mensch beschrieben. Bei geringen Konzentrationen in Bereichen der MIK-Werte kann es zu einer Steigerung der Empfindlichkeit des Bronchialsystems kommen. Der Organismus verfügt über Adaptationsmechanismen. Wahrscheinlich spielen Konzentrationsänderungen pro Zeiteinheit eine größere Rolle als die absoluten Konzentrationen. Höhere Konzentrationen können das Krankheitsbild der chronisch obstruktiven Bronchitis verursachen. Probanden, welche SO2 gegenüber am Arbeitsplatz exponiert sind, sollten mit ihrer Reagibilität des Bronchialsystems überwacht werden.
    Notes: Abstract SO2 shows different reactions on the lung and on the bronchial tree, depending on concentration and on duration of exposure. Low concentration can increase the sensitivity of the bronchial receptors, higher concentrations can directly increase the airway resistance. This reaction depends also on other particles inhaled at the same time. Coal dust (8 mg/m3) has no influence on the SO2 effect. Higher concentrations can cause chronic obstructive bronchitis, as could be shown in dogs. Persons exposed to SO2 at work should be checked for the reaction of their bronchial systems.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Lung 151 (1974), S. 73-86 
    ISSN: 1432-1750
    Keywords: Lung Tension ; Pneumothorax ; Airway Resistance ; Sensitivity of the Bronchial System ; Blockade of the N. Vagus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Entspannung der Lunge im Hundeversuch durch Pneumothorax und im Versuch an jungen und älteren Versuchspersonen durch Thoraxbandage führt zu einer Steigerung der Empfindlichkeit des Bronchialsystems im ACH-Test. Die nach Lungenentspannung unter Acetylcholin-Inhalation verstärkte bronchokonstriktorische Reaktion läßt sich durch direkte Vagusblockade (Hundeversuche) wie durch Atropininhalation (Menschen) verhindern. Es wird angenommen, daß die Lungenentspannung die Bronchialmuskulatur in einen Zustand bringt, welcher den von sensorischen Receptoren ausgehenden, über den Nervus vagus als Reflex laufenden bronchokonstriktorischen Reiz stärker beantworten läßt. Auf verschiedene Formen von „überempfindlichem Bronchialsystem“ wird hingewiesen. Die entsprechenden Meßwerte für Atemminutenvolumen, Atemtiefe und Atemfrequenz wie für die arteriellen Blutgase werden mitgeteilt.
    Notes: Abstract Decrease of lung tension increases the sensitivity of the bronchial system to acetylcholine inhalation. A decrease in lung tension was achieved by pneumothorax in dogs and with a thorax bandage in human subjects. The increase of airway resistance to acetylcholine inhalation following the decrease in lung tension was understood as a change of the effectiveness of the bronchial muscles on airway resistance. Acetylcholine works via sensoric receptors through the N. vagi on the bronchial muscles. Blockade of the N. vagi prevented an increase of sensitivity in the bronchial system. Measurements and results of breathing-volume per minute, breathing frequency, and blood gases are also described.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1750
    Keywords: Allergen ; Disodium Cromoglycate ; Airway Resistance ; Acetylcholine ; Histamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Respiratory hypersensitivity to ascaris extract aerosol and the potentation of airway resistance increase caused by acetylcholine and histamine challenge produced by this allergen exposition were carried out on four dogs. The effect of disodium cromoglycate on these reactions was also studied. All animals presented significant respiratory distress with ascaris extract aerosol, which could be avoided by previous exposure to disodium cromoglycate aerosol. The increased response of the bronchial system to acetylcholine and histamine, observed after allergen aerosol, could not be abolished by disodium cromoglycate aerosol.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1440
    Keywords: Chronic obstructive airway disease ; Arterial hypoxemia ; Liver function ; Galactose elimination capacity ; Indocyaninegreen clearance ; Oxygen therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Patients suffering from chronic obstructive airway disease often have arterial hypoxemia, which is more or less severe. If hypoxemia deteriorates the function of the liver is still unknown. The aim of this study was to determine, if a mostly oxygen dependent process of liver metabolism (galactose elimination capacity) is disturbed and if it can be increased by oxygen insufflation. Under the same conditions an oxygen independent process (indocyaninegreen clearance) should not be influenced. Our results show, that galactose elimination capacity under room air was pathologic and can be increased significantly by oxygen breathing. No change of indocyaninegreen clearance was seen under the same conditions. After termination of oxygen therapy the galactose elimination capacity was as bad as before oxygen breathing. Dysfunctions of the liver, which are caused by hypoxemia, can be positively influenced by oxygen, but only for the duration of oxygen insufflation.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Research in experimental medicine 178 (1981), S. 219-228 
    ISSN: 1433-8580
    Keywords: Papain inhalation ; Lung emphysema ; Chronic obstructive airway disease ; Hyperreactivity of bronchial system ; Papain-Inhalation ; Emphysementwicklung ; chronisch obstruktive Atemwegserkrankung ; überempfindliches Bronchialsystem
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei Hunden konnten durch Papain-Inhalation emphysematöse Lungenveränderungen erzeugt werden, die sich morphologisch als ein zentrolobuläres Lungenemphysem darstellen ließen. Weiterhin bewirkte die Inhalation von Papain eine chronische Bronchitis, die aber mit dem klinischen Bild der chronisch obstruktiven Atemwegserkrankung nicht vergleichbar war. Funktionell entwickelte sich eine Empfindlichkeitssteigerung der Atemwege ACH gegenüber. Das Bronchialsystem ließ auch Anzeichen einer sich steigernden Vulnerabilität durch Proteasen erkennen, die durch hierdurch auslösbare sehr starke Atemwegsobstruktionen funktionell faßbar wurde. Das Lungengewebe ist in Hinsicht Emphysementwicklung bei klinisch gesunden Hunden durch die Protease Papain vulnerabler als das Bronchialsystem in Hinsicht auf die Entwicklung einer chronisch obstruktiven Atemwegserkrankung.
    Notes: Summary Inhalation of papain by dogs produced morphological changes corresponding to a centrolobular emphysema. The papain inhalation also induced a purulent catarrhal bronchitis. However, the functional changes seen in chronic obstructive bronchitis were not observed. During papain inhalation an increased sensitivity of the bronchial system develops corresponding to a tremendous increase in bronchospasm in response to Acetylcholine aerosol. The parenchymal lung tissue in dogs is more vulnerable in developing emphysema after papain exposure than is the bronchial system in developing a chronic obstructive airway disease.
    Type of Medium: Electronic Resource
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