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  • Electronic Resource  (4)
  • Analytical Chemistry and Spectroscopy  (2)
  • Bacterial colonization  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Retention of the antibiotic teicoplanin on a hydromer-coated central venous catheter to prevent bacterial colonization in postoperative surgical patients (1996)
    Springer
    Intensive care medicine 22 (1996), S. 1066-1069 
    Details
    ISSN: 1432-1238
    Keywords: Central venous catheter ; Bacterial colonization ; Antimicrobial coating ; Teicoplanin ; Catheter-related infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective Antibioticcoated intravascular catheters may be an effective means of decreasing bacterial colonization and subsequent catheter-related infection. The present study was designed to investigate the retention of the antibiotic teicoplanin on a hydromer-coated intravenous catheter and the effect of this antibiotic coating on catheter bacterial colonization. Design A prospective, randomized pilot study. Setting Operating rooms (ORs) and an intensive care unit (ICU) at a university hospital. Patients A consecutive group of 20 male patients undergoing major abdominal surgery. Interventions Control (C,n=10) or teicoplanin-coated (T;n=10) single-lumen central venous catheters were inserted before surgery in the OR. Catheters were withdrawn at the discretion of the physicians in the ICU after various periods. Measurements The teicoplanin content of the catheter material was assessed using a bioassay withBacillus subtilis after complete elution of the antibiotic from the catheter. Bacterial colonization was measured using a quanitative culture technique after the catheter lumen had been flushed and the catheter segments sonicated. Main results Nearly three-quarters of the initial teicoplanin coating (374±103 μg; mean±SD) were released during the first day of catheterization, and after 36 h of intravenous catheterization, no antibiotic was retained on the catheter. No significant difference could be found either in the incidence of bacterial colonization between test (n=3) and control (n=4) catheters or in the number of colony-forming units (CFU) on the catheter segments (T, 263±104 CFU/cm; C, 372±294 CFU/cm; mean±SEM). Conclusion The retention of teicoplanin antibiotic coating on hydromer catheters is only short term if catheters are inserted intravenously. This may limit clinical antibacterial efficacy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01699229
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Retention of the antibiotic teicoplanin on a hydromer-coated central venous catheter to prevent bacterial colonization in postoperative surgical patients (1996)
    Springer
    Intensive care medicine 22 (1996), S. 1066-1069 
    Details
    ISSN: 1432-1238
    Keywords: Key words Central venous catheter ; Bacterial colonization ; Antimicrobial coating ; Teicoplanin ; Catheter-related infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: Antibiotic-coated intravascular catheters may be an effective means of decreasing bacterial colonization and subsequent catheter-related infection. The present study was designed to investigate the retention of the antibiotic teicoplanin on a hydromer-coated intravenous catheter and the effect of this antibiotic coating on catheter bacterial colonization. Design: A prospective, randomized pilot study. Setting: Operating rooms (ORs) and an intensive care unit (ICU) at a university hospital. Patients: A consecutive group of 20 male patients undergoing major abdominal surgery. Interventions: Control (C, n=10) or teicoplanin-coated (T; n=10) single-lumen central venous catheters were inserted before surgery in the OR. Catheters were withdrawn at the discretion of the physicians in the ICU after various periods. Measurements: The teicoplanin content of the catheter material was assessed using a bioassay with Bacillus subtilis after complete elution of the antibiotic from the catheter. Bacterial colonization was measured using a quanitative culture technique after the catheter lumen had been flushed and the catheter segments sonicated. Main results: Nearly three-quarters of the initial teicoplanin coating (374±103 μg; mean±SD) were released during the first day of catheterization, and after 36 h of intravenous catheterization, no antibiotic was retained on the catheter. No significant difference could be found either in the incidence of bacterial colonization between test (n=3) and control (n=4) catheters or in the number of colony-forming units (CFU) on the catheter segments (T, 263±104 CFU/cm; C, 372±294 CFU/cm; mean±SEM). Conclusion: The retention of teicoplanin antibiotic coating on hydromer catheters is only short term if catheters are inserted intravenously. This may limit clinical antibacterial efficacy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01699229
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Doubly charged porphyrin ion tandem mass spectrometry: Implications for structure elucidation (1989)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 24 (1989), S. 875-884 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Under electron ionization (EI) conditions, porphyrins yield unusually high intensities of doubly charged molecular and fragment ions. These doubly charged ions offer unique opportunities for the structure elucidation of porphyrins by tandem mass spectrometry (MS/MS). First, they fragment to a greater extent than the corresponding singly charged ions under both EI/MS and EI/MS/MS conditions. Second, doubly and singly charged porphyrin ions often fragment via different pathways, and can therefore yield different structural information. This paper describes several ways in which analyses of doubly charged porphyrin ions with a triple quadrupole tandem mass spectrometer can be useful in structure elucidation of porphyrins. The effect of the metal atom on the fragmentation of metalloporphyrins in an EI source is demonstrated by correlating the extent of doubly charged fragment ion formation to a stability index. Doubly charged porphyrin ions are shown to yield predominantly doubly charged daughter ions upon collisionally activated dissociation (CAD), and are also shown to fragment to a greater extent than corresponding singly charged porphyrin ions. Advantages and disadvantages of doubly charged porphyrin ion MS/MS for structure elucidation are discussed.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210241005
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Theory and numerical modeling of x-ray fluorescence from multi-layer spheres (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    X-Ray Spectrometry 20 (1991), S. 245-254 
    Details
    ISSN: 0049-8246
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: A mathematical model has been developed for the quantitative x-ray fluorescence spectrometry of small spherical samples, e.g. targets containing diagnostic materials for inertial confinement fusion experiments. The model corrects for matrix effects in a multi-layer spherical geometry much as existing programs now do for thin films or bulk samples. Attenuation effects have been found to be greater in a shell geometry than in a comparable thin-film geometry because multiple passes through the shell are possible and because many paths in or out are nearly tangential to the shell. In both cases the path is longer and attenuation is greater. The model for primary fluorescence from uniform shells has also been extended to approximate the fluorescence from non-uniform shells. This allows one to predict how experimental results would vary with sample mounting if excess material were oriented toward or away from the x-ray beam or the detector or away from both. Finally, a simplified model for estimating the magnitude of secondary fluorescence effects is presented.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/xrs.1300200506
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    Paper (German National Licenses)
    Fulltext
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