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  • 1
    Electronic Resource
    Electronic Resource
    Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity (1994)
    Springer
    Virchows Archiv 425 (1994), S. 3-24 
    Details
    ISSN: 1432-2307
    Keywords: Cytoskeleton ; Wound healing ; Fibrosis ; Extracellular matrix ; Cytokine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Granulation tissue fibroblasts (myofibroblasts) develop several ultrastructural and biochemical features of smooth muscle (SM) cells, including the presence of microfilament bundles and the expression of α-SM actin, the actin isoform present in SM cells and myoepithelial cells and particularly abundant in vascular SM cells. Myofibroblasts have been suggested to play a role in wound contraction and in retractile phenomena observed during fibrotic diseases. When contraction stops and the wound is fully epithelialized, myofibroblasts containing α-SM actin disappear, probably as a result of apoptosis, and the scar classically becomes less cellular and composed of typical fibroblasts with well-developed rough endoplasmic reticulum but with no more microfilaments. In contrast, α-SM actin expressing myofibroblasts persist in hypertrophic scars and in fibrotic lesions of many organs, including stroma reaction to epithelial tumours, where they are allegedly involved in retractile phenomena as well as in extracellular matrix accumulation. The mechanisms leading to the development of myofibroblastic features remain to be investigated. In vivo and in vitro investigations have shown that γ-interferon exerts an antifibrotic activity at least in part by decreasing α-SM actin expression whereas heparin increases the proportion of α-SM actin positive cells. Recently, we have observed that the subcutaneous administration of transforming growth factor-β1 to rats results in the formation of a granulation tissue in which α-SM actin expressing myofibroblasts are particularly abundant. Other cytokines and growth factors, such as platelet-derived growth factor, basic fibroblast growth factor and tumour necrosis factor-α, despite their profibrotic activity, do not induce α-SM actin in myofibroblasts. In conclusion, fibroblastic cells are relatively undifferentiated and can assume a particular phenotype according to the physiological needs and/or the microenvironmental stimuli. Further studies on fibroblast adaptation phenomena appear to be useful for the understanding of the mechanisms of development and regression of pathological processes such as wound healing and fibrocontractive diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00193944
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  • 2
    Electronic Resource
    Electronic Resource
    Primäre pulmonale B-Zell-Lymphome vom MALT-Typ (1995)
    Springer
    Der Pathologe 16 (1995), S. 328-335 
    Details
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Bronchus-assoziiertes lymphatisches Gewebe ; Marginalzonen ; B-Zell-Lymphome ; Reaktive Keimzentren ; Follikelkolonisation ; Lymphoepitheliale Läsionen ; Key words Bronchus-associated lymphoid tissue ; Marginalzone B-cell lymphoma ; Reactive germinal centers ; Follicular colonisation ; Lymphoepithelial lesions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The malignant B-cell lymphoma of the MALT-type shows significant differences from nodal lymphomas with respect to its biological, molecular genetic, and clinical properties. According to the proposal from the International Lymphoma Study Group for a Revised European-American Classification of Lymphoid Neoplasms, MALT-B-cell lymphomas have been defined as an extranodal subgroup of marginal zone B-cell lymphomas and may have lower and higher grade types. We have applied this classification to 24 cases of primary B-cell lymphomas of the lung. These tumors showed histopathologic features of low (n = 20) and/or high grade neoplasms (n = 4) recapitulating the structure of the acquired bronchus- associated lymphoid tissue (BALT). According to our experience, the diagnosis of BALT-type B-cell lymphoma, is both practically feasable and reproducible not only for surgical material but even for biopsy specimens.
    Notes: Zusammenfassung Maligne B-Zell-Lymphome vom MALT-Typ unterscheiden sich signifikant von nodalen Lymphomen bzgl. ihrer biologischen, molekulargenetischen und klinischen Eigenschaften. Nach den Vorschlägen der Internationalen Lymphom-Studiengruppe für eine revidierte europäisch-amerikanische Klassifikation lymphatischer Neoplasien sind MALT-B-Zell-Lymphome als extranodale Form von Marginalzonen-B-Zell-Lymphomen definiert, die einen niedrigeren oder höheren Malignitätsgrad aufweisen können. Wir wandten dieses Klassifikationskonzept auf 24 Fälle primärer pulmonaler B-Zell-Lymphome an. Alle Fälle zeigten histologische Merkmale niedrigmaligner (n = 20) und/oder hochmaligner Neoplasien (n = 4), die die Struktur des erworbenen bronchusassoziierten lymphatischen Gewebes (BALT) rekapitulierten. Nach unserer Erfahrung, ist die Diagnose von B-Zell-Lymphomen des BALT-Typs nicht allein an chirurgischen Resektaten, sondern auch an Biopsien in der praktischen Diagnostik möglich und reproduzierbar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002920050110
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    Paper (German National Licenses)
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