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  • Electronic Resource  (17)
  • Engineering General  (7)
  • Rat  (6)
  • Biochemistry  (4)
  • 1
    Electronic Resource
    Electronic Resource
    (±)-1-(2,5-Dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2), a novel putative anxiolytic agent lacking affinity for benzodiazepine sites and serotonin-1A receptors (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 354 (1996), S. 579-585 
    Details
    ISSN: 1432-1912
    Keywords: ALEPH-2 Serotonin receptor binding ; Anxiolytics ; Serotonin syndrome ; Phenylisopropylamines ; Rat ; Hypothermia ; Psychedelics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Serotonergic behavioral responses, effects on motor activity and core temperature, and binding properties of the novel putative anxiolytic amphetamine derivative (±)1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2), were examined in rodents in order to elucidate the mechanism underlying its anxiolytic-like effect. After peripheral administration in rats, ALEPH-2 induced some symptoms of the serotonergic syndrome, e.g. forepaw treading and flat body posture. Additionally, a decrease in motor activity was observed. No significant effects on the number of head shakes were observed after injection, although high inter-subject variability was noted. Higher doses of ALEPH-2, in the range exhibiting anxiolytic properties (4mg/kg), elicited significant hypothermia in mice. The affinity of the drug for 5-HT2A/2C receptors ([3H]ketanserin sites) was in the nanomolar range (Ki = 173 nM), whereas for 5-HT1A, benzodiazepine sites, and GABAA receptors, the affinity was micromolar or lower. Based on these results the mechanism of action and the anxiolytic-like properties of ALEPH-2 are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00170831
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    (±)-1-(2,5-Dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2) a novel putative anxiolytic agent lacking affinity for benzodiazepine sites and serotonin-1A receptors (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 354 (1996), S. 579-585 
    Details
    ISSN: 1432-1912
    Keywords: Key words ALEPH-2 ; Serotonin receptor binding ; Anxiolytics ; Serotonin syndrome ; Phenylisopropylamines ; Rat ; Hypothermia ; Psychedelics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Serotonergic behavioral responses, effects on motor activity and core temperature, and binding properties of the novel putative anxiolytic amphetamine derivative (±)1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2), were examined in rodents in order to elucidate the mechanism underlying its anxiolytic-like effect. After peripheral administration in rats, ALEPH-2 induced some symptoms of the serotonergic syndrome, e.g. forepaw treading and flat body posture. Additionally, a decrease in motor activity was observed. No significant effects on the number of head shakes were observed after injection, although high inter-subject variability was noted. Higher doses of ALEPH-2, in the range exhibiting anxiolytic properties (4mg/kg), elicited significant hypothermia in mice. The affinity of the drug for 5-HT2A/2C receptors ([3H]ketanserin sites) was in the nanomolar range (Ki=173 nM), whereas for 5-HT1A, benzodiazepine sites, and GABAA receptors, the affinity was micromolar or lower. Based on these results the mechanism of action and the anxiolytic-like properties of ALEPH-2 are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00170831
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of nicotine on the acoustic startle reflex amplitude in rats (1991)
    Springer
    Psychopharmacology 104 (1991), S. 244-248 
    Details
    ISSN: 1432-2072
    Keywords: Nicotine ; Startle ; Reflex ; Sensorimotor reactivity ; Rat ; Attention
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The acoustic startle reflex was used to measure changes in sensorimotor reactivity in response to nicotine administration and cessation. Male rats received saline, 6 mg/kg/day or 12 mg/kg/day nicotine delivered subcutaneously by osmotic minipumps. The pumps delivered their contents during a 10-day period of implantation, after which time they were explanted. Animals were tested for startle reflex amplitudes using two levels of white noise bursts prior to pump implantation, on days 1 and 7 of nicotine or saline administration, and on several days following drug cessation. Nicotine produced a dose-dependent increase in startle amplitude during the period of administration that decreased during cessation. Results are interpreted in terms of nicotine's actions to enhance attentional processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244186
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  • 4
    Electronic Resource
    Electronic Resource
    The tanycyte of the rat median eminence (1979)
    Springer
    Cell & tissue research 200 (1979), S. 329-334 
    Details
    ISSN: 1432-0878
    Keywords: Median eminence ; Axon terminals ; Tanycytes ; Electron microscopy ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The present ultrastructural study proves the existence of nerve terminals closely apposed to the plasmalemmata of tanycytes in the rat median eminence. Several of these “axo-tanycytic” endings display remarkable accumulations of agranular endoplasmic reticulum in the form of pleomorphic vesicles which are closely apposed on either side of the plasma membrane of each cell compartment. Some of these vesicular profiles give the impression of structural continuity across both membrane systems. This phenomenon is discussed in the context of being a potential substratum for communication between both cell compartments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236425
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  • 5
    Electronic Resource
    Electronic Resource
    In vitro analysis of the cellular localization of luteinizing hormone releasing factor (LRF) in the basal hypothalamus of the rat (1974)
    Springer
    Cell & tissue research 149 (1974), S. 371-378 
    Details
    ISSN: 1432-0878
    Keywords: LRF ; Hypothalamic localization ; Rat ; Ependyma ; Glia ; Light and electron microscopic Autoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Light and electron microscopic autoradiographic analysis of the medial basal hypothalamus of rat brains incubated for 30 and 60 minutes in tritiated luteinizing releasing factor (3H-LRF) revealed selective uptake in the form of silver grains over specialized ependyma (tanycytes) and perivascular glial cells in the palisade-contact zone of the median eminence. The functional capacity of tanycytes and glia are discussed in light of these data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00226771
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  • 6
    Electronic Resource
    Electronic Resource
    Ultrastructural changes in the median eminence of the rat following deafferentation of the basal hypothalamus (1970)
    Springer
    Cell & tissue research 105 (1970), S. 1-32 
    Details
    ISSN: 1432-0878
    Keywords: Median eminence ; Rat ; Deafferentation ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary This report concerns a light and electron microscopic investigation of the median eminence and dorsal infundibular stem of the rat following surgical isolation (deafferentation). Using a modification of the Halász technique, the basal hypothalamus, including the arcuate nucleus and median eminence were surgically isolated from surrounding structures. Special attention was directed to the contact (external) zone of the median eminence and rostral infundibulum where tuberohypophyseal axons as well as ependymal cell processes abut upon the abluminal basement membrane of the portal perivascular space. The results of this study to date suggest that 9, 20, and 40 days following surgical isolation, there is a distinct increase in the population of tuberohypophyseal dense core vesicles. It is suggested that deafferentation abolishes inhibitory and excitatory input that serves to modify the cellular dynamics of tuberohypophyseal neurosecretory elements. Comments are also made on the presence of cistern-like structures in the lateral median eminence; the presence of vesicle-like inclusions in terminal ependymal processes is discussed in relationship to the role that ependyma may play in linking the third ventricle with the adenohypophysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00340562
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  • 7
    Electronic Resource
    Electronic Resource
    Immunocytochemical and biochemical studies of histamine in the retina of the turtle Pseudemys scripta (1992)
    Springer
    Cell & tissue research 267 (1992), S. 449-454 
    Details
    ISSN: 1432-0878
    Keywords: Histamine ; Biochemistry ; Immunocytochemistry ; Retina ; Photoreceptors ; Paraboloid ; Turtle, Pseudemys scripta (Chelonia)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A combination of immunocytochemical and biochemical methods was used to study histamine in the turtle retina. Histamine-like immunoreactivity was localized within paraboloids of certain cone photoreceptors by use of two different antisera directed against histamine. Preincubation of eyecups in Ringer's containing 10 μM histamine selectively increased the immunoreactivity of these photoreceptor paraboloids. The present localization of histamine in paraboloids indicated that, although histamine is in photoreceptors of the turtle retina, it may play some metabolic or neuromodulatory role, and not function as a neurotransmitter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319367
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  • 8
    Electronic Resource
    Electronic Resource
    A predictor-corrector contouring algorithm for isoparametric 3D elements (1983)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 19 (1983), S. 995-1004 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper describes a new contouring algorithm for isoparametric elements which can be used to map three-dimensional scalar fields. The contours are generated on arbitrary planes intersecting finite element structures. Tracing element contour lines is accomplished by an accurate predictor-corrector technique. A method of finding starting points for the algorithm on the boundary of the elements is also given.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620190705
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  • 9
    Electronic Resource
    Electronic Resource
    A parallel boundary element formulation for determining effective properties of heterogeneous media (1994)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 37 (1994), S. 3905-3919 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper presents a parallel implementation of the boundary element method for MIMD computer architectures to determine the effective properties of two heterogeneous physical systems. The first physical system is comprised of spheres sedimenting in a viscous fluid at low Reynolds numbers. The effective property is characterized by the hindered settling function which is a measure of the average sedimentation velocity. The second physical system is a short-fibre reinforced composite. The effective property for this system is the composite modulus. The determination of effective properties of heterogeneous media requires performing statistical analyses of several realizations of physical systems based on defining characteristics of the media. The boundary element method is particularly well suited for studying such systems because of the simplification in the discretization associated with the method. However, as the number of heterogeneities to be modeled is increased so are the computational demands. Parallel computation offers the opportunity to model systems of greater complexity. We discuss a parallel boundary element formulation based on the torus-wrap mapping. In this approach, blocks of the coefficient matrix associated with the discretized boundary element equations are assigned to processors as opposed to more traditional parallel boundary element implementations where rows or columns are assigned to processors. The torus-wrap mapping can be shown to minimize communication volume between processors during the LU factorization. Therefore, the present formulation scales well with increases in the number of processors.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620372209
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  • 10
    Electronic Resource
    Electronic Resource
    A comparison of some domain decomposition and ILU preconditioned iterative methods for nonsymmetric elliptic problems (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Numerical Linear Algebra with Applications 1 (1994), S. 477-504 
    Details
    ISSN: 1070-5325
    Keywords: Domain decomposition ; Preconditioning ; Iterative methods ; Nonsymmetric and/or indefinite elliptic problems ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: In recent years, competitive domain-decomposed preconditioned iterative techniques of Krylov-Schwarz type have been developed for nonsymmetric linear elliptic systems. Such systems arise when convection-diffusion-reaction problems from computational fluid dynamics or heat and mass transfer are linearized for iterative solution. Through domain decomposition, a large problem is divided into many smaller problems whose requirements for coordination can be controlled to allow effective solution on parallel machines. A central question is how to choose these small problems and how to arrange the order of their solution. Different specifications of decomposition and solution order lead to a plethora of algorithms possessing complementary advantages and disadvantages. In this report we compare several methods, including the additive Schwarz algorithm, the classical multiplicative Schwarz algorithm, an accelerated multiplicative Schwarz algorithm, the tile algorithm, the CGK algorithm, the CSPD algorithm, and also the popular global ILU-family of preconditioners, on some nonsymmetric or indefinite elliptic model problems discretized by finite difference methods. The preconditioned problems are solved by the unrestarted GMRES method. A version of the accelerated multiplicative Schwarz method is a consistently good performer.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nla.1680010504
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