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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Der Radiologe 36 (1996), S. 337-344 
    ISSN: 1432-2102
    Keywords: Schlüsselwörter PET ; Kosteneffektivität ; Neurologie ; Kardiologie ; Onkologie ; Key words PET ; Cost effectiveness ; Neurology ; Cardiology ; Oncology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary To date, positron emission tomography (PET) is the most powerful tool for the non-invasive study of biochemical processes. Besides its usefulness for basic research PET has been proven to be superior to conventional diagnostic methods in several clinical indications. However, the introduction of PET into clinical practice has been hindered considerably by its costs. Several American studies lend support to the hypothesis that PET may be more cost-effective than the conventional diagnostic work-up – at least for some of its clinical indications. In Germany, however, this hypothesis has still not been verified.
    Notes: Zusammenfassung Die Positronenemissionstomographie (PET) ist derzeit das leistungsstärkste Verfahren zur In-vivo-Analyse biochemischer Prozesse. Neben der Bedeutung dieser Technologie für die Grundlagenwissenschaften haben sich in den letzten Jahren auch eine Reihe klinischer Indikationen für PET herauskristallisiert. Der Einführung der PET in die klinische Praxis steht ihr hoher Aufwand an Mitteln und Personal entgegen. Durch Verknappung der Ressourcen im Gesundheitssystem ist die Analyse des Verhältnisses zwischen Kosten und Nutzen der PET noch zusätzlich relevant und aktuell geworden. Dieses kontrastiert mit dem Mangel der diesem Thema gewidmeten Publikationen. Die bisher publizierten, auf US-amerikanische Verhältnisse abhebenden Modellanalysen lassen vermuten, daß PET zumindest bei einem Teil ihrer klinischen Indikationen ein besseres Kosten-Nutzen-Verhältnis aufweist als bisher übliche diagnostische Verfahren; eine Prüfung dieser Behauptung für deutsche Verhältnisse steht jedoch noch aus.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 14 (1988), S. 446-452 
    ISSN: 1619-7089
    Keywords: Brain death ; Cerebral blood flow ; Pediatric intensive care ; Organ donation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Determination of brain death in infants and children is difficult and criteria used in adult brain death are regarded insufficient in pediatric cases. In comatose children, clinical signs of brain death and EEG monitoring may be of limited value, while intercerebral blood flow estimations can provide more direct information. Beside radionuclide bolus angiography of polar radiopharmaceuticals with sequential technique, two radioisotopes are introduced for static brain images. Injection of 123I-amphetamine or the 99mTc labelled lipophilic complex HM-PAO into the peripheral venous circulation enables more precise static imaging of parenchymatous brain perfusion and cellular function in contrast to conventional dynamic imaging because of retention in the intact brain parenchyma. Critical deficits or complete loss of cerebral perfusion can be readily documented. These studies are particularly helpful when clinical signs and EEG alone cannot establish the definite diagnosis of brain death. Their easy application and wide availability renders them especially useful in children.
    Type of Medium: Electronic Resource
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