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  • Digitale Medien  (3)
  • Brain tumour  (1)
  • Dopamine D2-receptor  (1)
  • Metabolic imaging  (1)
  • 1
    Digitale Medien
    Digitale Medien
    On the principles underlying the diagnosis of brain tumours — A survey article (1995)
    Springer
    Acta neurochirurgica 135 (1995), S. 1-11 
    Details
    ISSN: 0942-0940
    Schlagwort(e): Brain tumour ; brain oedema ; blood brain barrier
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A survey is given of the principles underlying the diagnosis of brain tumours. Traditionally diagnosis and localization of brain tumours have been based upon morphological criteria. Currently unsurpassed levels in imaging of anatomical details and topographical relations by the techniques of computed tomography (CT) and magnetic resonance imaging (MRI) have been achieved. The techniques of positron emission tomography (PET) and of magnetic resonance spectroscopy (MRS), which depict also metabolic and blood flow aspects, provide a refinement of our knowledge on the metabolism, structure and pathophysiological relations of a tumour to the surrounding parenchyma. Recent advances in the recording of function-related changes of the cerebral electro-magnetic field allow a better definition of critical functional areas.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02307407
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Neurotransmitter positron emission tomographic-studies in adults with phenylketonuria, a pilot study (1996)
    Springer
    European journal of pediatrics 155 (1996), S. S78 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Key words Phenylketonuria ; Positron emission tomography ; Dopamine D2-receptor
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Patients with phenylketonuria (PKU) may suffer from cognitive and neurological deficits which are related to reduced intracerebral concentrations of catecholamines. The function of phenylalanine (Phe) as an inhibitor of the uptake of the precursor amino acid tyrosine (Tyr) through the blood-brain barrier as well as an inhibitor of the expression of dopamine receptors in the brain is under investigation. Positron emission tomography (PET) is a method for quantitatively determining biochemical and physiological processes in vivo. In the current pilot study, l-[1-11C]-Tyr and 18F-fluoro-ethyl-spiperone (FESP) have been used. The metabolic pathway of carboxylic labelled Tyr is mainly incorporation into protein. From the measured tissue and plasma activity as a function of time in combination with a compartimental model the Protein Synthesis Rate (PSR) for Tyr can be calculated. FESP is a ligand which binds irreversibly to the dopamine D2-receptor and has also a low non specific binding, although affinity to the serotonin receptor has been described. The ratio of FESP concentration in striatum and in cerebellum is a measure of the receptor status in vivo. In patients with plasma Phe levels above the maximum therapeutic concentration (〉 700 μmol/l) the PSR for Tyr was decreased as compared to controls and patients with plasma Phe concentrations within the therapeutic range, indicating a decreased availability of Tyr for neurotransmitter synthesis, and hence explaining the reduced cerebral concentration of catecholamines.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/PL00014257
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  • 3
    Digitale Medien
    Digitale Medien
    A comparison of the sensitivity of PET and NMR for in vivo quantitative metabolic imaging (1985)
    Springer
    European journal of nuclear medicine 11 (1985), S. 73-75 
    Details
    ISSN: 1619-7089
    Schlagwort(e): Metabolic imaging ; PET ; NMR
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Using positron emission tomography (PET) in combination with compounds labelled with positron-emitting radionuclides like 11C, 13N and 15O, it is possible to study metabolism in vivo in a non-invasive way. Nuclear magnetic resonance (NMR) imaging takes advantage of the spin of protons in water molecules to measure both their number and relaxation times in vivo, but is, in principle, not limited to protons and can also be used for other nuclei with a non-zero spin, e.g. 13C and 31P. The use of 13C opens the possibility of studying the metabolism of a large number of compounds. In order to choose the appropriate methodology for metabolic imaging, i.e. PET or NMR, it is important to know the sensitivity of each modality. The present study outlines the sensitivity of both techniques.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00252137
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