ISSN:
1433-8580
Keywords:
Biliary obstruction
;
Biliary sepsis
;
Cholangitis
;
Intrabiliary injection
;
E. coli
;
Rats
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The effect of retrograde intrabiliary (RI) injection ofE. coli was studied in Sprague-Dawley rats with biliary obstruction of different duration (3 days; 2, 4, and 6 weeks). By the injection of 105 colony-forming units (CFU) immediately after occlusion of the common bile duct (CBD), 15 of 18 normal rats survived without clinical signs of infection. In contrast, six of 11 animals in 3-day obstruction (P = 0.04), seven of 12 in 2-week obstruction (P = 0.02), ten of 12 in both 4-week and 6-week obstruction (P = 0.0004) died ofE. coli sepsis after injection of the same amount of bacteria. Animals with longstanding jaundice (4 and 6 weeks) were more susceptible than those with a shorter duration of jaundice (3 days and 2 weeks,P = 0.04). The results warrant the early decompression of the biliary tract in biliary obstruction.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01854896
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